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Low molecular weight heparin and aspirin for prevention of deep vein thrombosisafter orthopaedic surgery: a systematic review and meta-analysis

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Abstract

To comprehensively evaluate the clinical effects of low molecular weight heparin (LMWH) and aspirin for deep vein thrombosis (DVT) patients after orthopaedic surgery. Studies comparing LMWH and aspirin were retrieved in multiple databases. Review Manager 5.0 was adopted for meta-analysis, sensitivity analysis and bias analysis. Finally, 4460 patients in 6 studies were included, and the eligibility criteria were finally met. The meta-analysis suggested that there was significant difference between LMWH and aspirin groups in DVT (RR = 0.58, 95%CI [0.39, 0.88], P = 0.01; P for heterogeneity = 0.45, I2 = 0%). Postoperative bleeding between the two groups showed no difference (RR = 2.20, 95%CI [0.48, 10.09], P = 0.31; P for heterogeneity = 0.79, I2 = 0%) This study shows that LMWH is a more effective therapy than aspirin for patients with DVT after orthopaedic surgery.

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Authors and Affiliations

  1. Departments of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

    Bo Chen

  2. Departments of Tumor Chemoradiotherapy, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

    Nie Hu

  3. Department of Tumor Chemoradiotherapy, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan, 430071, Hubei, China

    Nie Hu

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Correspondence to Nie Hu.

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Chen, B., Hu, N. Low molecular weight heparin and aspirin for prevention of deep vein thrombosisafter orthopaedic surgery: a systematic review and meta-analysis. J Thromb Thrombolysis 52, 553–559 (2021). https://doi.org/10.1007/s11239-020-02348-5

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