Skip to main content

Advertisement

Log in

Highlights from the I international symposium of thrombosis and anticoagulation in internal medicine, October 23–25, 2008, Sao Paulo, Brazil

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

Abstract

The importance of thrombosis and anticoagulation in clinical practice is rooted firmly in several fundamental constructs that can be applied both broadly and globally. Awareness and the appropriate use of anticoagulant therapy remain the keys to prevention and treatment. However, to assure maximal efficacy and safety, the clinician must, according to the available evidence, choose the right drug, at the right dose, for the right patient, under the right indication, and for the right duration of time. The first International Symposium of Thrombosis and Anticoagulation in Internal Medicine was a scientific program developed by clinicians for clinicians. The primary objective of the meeting was to educate, motivate and inspire internists, cardiologists and hematologists by convening national and international visionaries, thought-leaders and dedicated clinician-scientists in Sao Paulo, Brazil. This article is a focused summary of the symposium proceedings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Hirsh J, Guyatt G, Albers GW, Harrington R, Schünemann HJ, American College of Chest Physicians (2008) Executive summary: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):71S–109S. doi:10.1378/chest.08-0693. No abstract available

    Article  PubMed  Google Scholar 

  2. Bonetti PO, Lerman LO, Lerman A (2003) Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23(2):168–175. doi:10.1161/01.ATV.0000051384.43104.FC

    Article  PubMed  CAS  Google Scholar 

  3. Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87(10):840–844

    PubMed  CAS  Google Scholar 

  4. Alheid U, Frölich JC, Förstermann U (1987) Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb Res 47(5):561–571. doi:10.1016/0049-3848(87)90361-6

    Article  PubMed  CAS  Google Scholar 

  5. Libby P (2008) The molecular mechanisms of the thrombotic complications of atherosclerosis. J Intern Med 263(5):517–527. doi:10.1111/j.1365-2796.2008.01965.x

    Article  PubMed  CAS  Google Scholar 

  6. Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G, American College of Chest Physicians (2008) Executive summary: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):160S–198S. doi:10.1378/chest.08-0670

    Article  PubMed  CAS  Google Scholar 

  7. Antman EM, Hand M, Armstrong PW, Bates ER, Green LA, Halasyamani LK, Hochman JS, Krumholz HM, Lamas GA, Mullany CJ, Pearle DL, Sloan MA, Smith SC Jr (2008) 2004 writing committee members, Anbe DT, Kushner FG, Ornato JP, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Halperin JL, Hunt SA, Lytle BW, Nishimura R, Page RL, Riegel B, Tarkington LG, Yancy CW. 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians: 2007 writing group to review new evidence and update the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction, writing on behalf of the 2004 writing committee. Circulation 117(2):296–329. doi:10.1161/CIRCULATIONAHA.107.188209. No abstract available

    Google Scholar 

  8. Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE II, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS, Smith SC Jr, Jacobs AK, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B, American College of Cardiology (2007) American Heart Association Task Force on Practice Guidelines (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction); American College of Emergency Physicians; Society for Cardiovascular Angiography and Interventions; Society of Thoracic Surgeons; American Association of Cardiovascular and Pulmonary Rehabilitation; Society for Academic Emergency Medicine. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation 116(7):e148–e304. doi:10.1161/CIRCULATIONAHA.107.181940. No abstract available

    Google Scholar 

  9. Lopes RD, Pieper KS, Horton JR, Al-Khatib SM, Newby LK, Mehta RH, Van de Werf F, Armstrong PW, Mahaffey KW, Harrington RA, Ohman EM, White HD, Wallentin L, Granger CB (2008) Short- and long-term outcomes following atrial fibrillation in patients with acute coronary syndromes with or without ST-segment elevation. Heart 94(7):867–873. doi:10.1136/hrt.2007.134486

    Article  PubMed  CAS  Google Scholar 

  10. Lopes RD, Piccini JP, Hylek EM, Granger CB, Alexander JH (2008) Antithrombotic therapy in atrial fibrillation: guidelines translated for the clinician. J Thromb Thrombolysis 26(3):167–174. doi:10.1007/s11239-008-0272-4

    Article  PubMed  CAS  Google Scholar 

  11. Hylek EM, Becker RC (2008) Atrial fibrillation and stroke severity: expanding the mechanistic exemplar, clinical phenotype, and goals of anticoagulant pharmacotherapy. Ann Neurol 64(5):480–483. doi:10.1002/ana.21551

    Article  PubMed  CAS  Google Scholar 

  12. Tapson VF, Decousus H, Pini M, Chong BH, Froehlich JB, Monreal M, Spyropoulos AC, Merli GJ, Zotz RB, Bergmann JF, Pavanello R, Turpie AG, Nakamura M, Piovella F, Kakkar AK, Spencer FA, Fitzgerald G, Anderson FA Jr (2007) IMPROVE Investigators. Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism. Chest 132(3):936–945. doi:10.1378/chest.06-2993

    Article  PubMed  Google Scholar 

  13. Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Deslandes B, Huang W, Zayaruzny M, Emery L, Anderson FA Jr (2008) ENDORSE Investigators. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet 371(9610):387–394. doi:10.1016/S0140-6736(08)60202-0

    Article  PubMed  Google Scholar 

  14. Sherman DG, Albers GW, Bladin C, Fieschi C, Gabbai AA, Kase CS, O’Riordan W, Pineo GF (2007) PREVAIL Investigators. The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL study): an open-label randomised comparison. Lancet 369(9570):1347–1355. doi:10.1016/S0140-6736(07)60633-3

    Article  PubMed  CAS  Google Scholar 

  15. Spencer FA, Lessard D, Emery C, Reed G, Goldberg RJ (2007) Venous thromboembolism in the outpatient setting. Arch Intern Med 167(14):1471–1475. doi:10.1001/archinte.167.14.1471

    Article  PubMed  Google Scholar 

  16. Rocha AT, Paiva EF, Lichtenstein A, Milani R Jr, Cavalheiro CF, Maffei FH (2007) Risk-assessment algorithm and recommendations for venous thromboembolism prophylaxis in medical patients. Vasc Health Risk Manag 3(4):533–553. Review

    PubMed  Google Scholar 

  17. Eriksson BI, Borris LC, Friedman RJ, Haas S, Huisman MV, Kakkar AK, Bandel TJ, Beckmann H, Muehlhofer E, Misselwitz F, Geerts W (2008) RECORD1 Study Group. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 358(26):2765–2775. doi:10.1056/NEJMoa0800374

    Article  PubMed  CAS  Google Scholar 

  18. Kakkar AK, Brenner B, Dahl OE, Eriksson BI, Mouret P, Muntz J, Soglian AG, Pap AF, Misselwitz F, Haas S (2008) RECORD2 Investigators. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet 372(9632):31–39. doi:10.1016/S0140-6736(08)60880-6

    Article  PubMed  CAS  Google Scholar 

  19. Lassen MR, Ageno W, Borris LC, Lieberman JR, Rosencher N, Bandel TJ, Misselwitz F, Turpie AG (2008) RECORD3 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 358(26):2776–2786. doi:10.1056/NEJMoa076016

    Article  PubMed  CAS  Google Scholar 

  20. Garcia DA, Regan S, Henault LE, Upadhyay A, Baker J, Othman M, Hylek EM (2008) Risk of thromboembolism with short-term interruption of warfarin therapy. Arch Intern Med 168(1):63–69. doi:10.1001/archinternmed.2007.23

    Article  PubMed  CAS  Google Scholar 

  21. Weitz JI, Hirsh J, Samama MM, American College of Chest Physicians (2008) New antithrombotic drugs: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):234S–256S. Erratum in: Chest. 2008 Aug;134. 2:473. doi:10.1378/chest.08-0673

  22. Douketis JD, Berger PB, Dunn AS, Jaffer AK, Spyropoulos AC, Becker RC, Ansell J, American College of Chest Physicians (2008) The perioperative management of antithrombotic therapy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):299S–339S. doi:10.1378/chest.08-0675

    Article  PubMed  CAS  Google Scholar 

  23. Salem DN, O’Gara PT, Madias C, Pauker SG, American College of Chest Physicians (2008) Valvular and structural heart disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):593S–629S. doi:10.1378/chest.08-0724

    Article  PubMed  Google Scholar 

  24. Warkentin TE, Greinacher A, Koster A, Lincoff AM, American College of Chest Physicians (2008) Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):340S–380S. doi:10.1378/chest.08-0677

    Article  PubMed  CAS  Google Scholar 

  25. Lyman GH, Khorana AA, Falanga A, Clarke-Pearson D, Flowers C, Jahanzeb M, Kakkar A, Kuderer NM, Levine MN, Liebman H, Mendelson D, Raskob G, Somerfield MR, Thodiyil P, Trent D, Francis CW, American Society of Clinical Oncology (2007) American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer. J Clin Oncol 25(34):5490–5505. doi:10.1200/JCO.2007.14.1283. Review

    Article  PubMed  CAS  Google Scholar 

  26. Gage BF, Lesko LJ (2008) Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues. J Thromb Thrombolysis 25(1):45–51. doi:10.1007/s11239-007-0104-y. Review

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The I International Symposium of Thrombosis and Anticoagulation in Internal Medicine was sponsored by an unrestricted grant from Sanofi-aventis. The symposium was organized by Meeting Eventos, and the chairmen of the meeting thank Cecilia Jahnel and Fernanda Prestes for all the support in the organization.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard C. Becker.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lopes, R.D., Becker, R.C., Garcia, D. et al. Highlights from the I international symposium of thrombosis and anticoagulation in internal medicine, October 23–25, 2008, Sao Paulo, Brazil. J Thromb Thrombolysis 28, 106–116 (2009). https://doi.org/10.1007/s11239-009-0324-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-009-0324-4

Keywords

Navigation