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Synthesis and crystal structure of 1-benzyl-2-(4-benzyloxyphenyl)-5,6-dichloro-1H-benzimidazole

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Abstract

In this study 1-benzyl-2-(4-benzyloxyphenyl)-5,6-dichloro-1H-benzimidazole, II, was synthesised. Elemental analyses, 1H-NMR, and single-crystal structure determination have been carried out. The benzimidazole ring system is planar as expected. The molecules of II are arranged in rows running parallel to the b-axis with the molecules in adjacent rows inverted.

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References

  1. Köhler P (2001) Int J Parasitol 31:336–345

    Article  Google Scholar 

  2. Islam I, Skibo EB, Dorr RT, Alberts DS (1991) J Med Chem 34:2954–2961

    Article  CAS  Google Scholar 

  3. Kruse LI, Ladd DL, Harrsch PB, McCabe FL, Mong SM, Faucette L, Johnson R (1989) J Med Chem 32:409–417

    Article  CAS  Google Scholar 

  4. Fukuda T, Saito T, Tajima S, Shimohara K, Ito K (1984) Arzneim–Forsch/Drug Res 34:805–810

    CAS  Google Scholar 

  5. Nakano H, Inoue T, Kawasaki N, Miyataka H, Matsumoto H, Taguchi T, Inagaki N, Nagai H, Satoh T (1999) Chem Pharm Bull 47:1573–1578

    CAS  Google Scholar 

  6. Nakano H, Inoue T, Kawasaki N, Miyataka H, Matsumoto H, Taguchi T, Inagaki N, Nagai H, Satoh T (2000) Bioorg Med Chem 8:373–380

    Article  CAS  Google Scholar 

  7. Ayhan-Kilcigil G, Kus C, Coban T, Can-Eke B, Özbey S, Iscan M (2005) J Enzyme Inhib Med Chem 20:503–514

    Article  CAS  Google Scholar 

  8. Ates-Alagoz Z, Kus C, Coban T (2005) J Enzyme Inhib Med Chem 20:325–331

    Article  CAS  Google Scholar 

  9. Ates-Alagoz Z, Can-Eke B, Coban T, Iscan M, Büyükbingol E (2004) Arch Pharm Pharm Med Chem 337:188–192

    Article  CAS  Google Scholar 

  10. Agarwal R, Agarwal C, Kumar P (1984) Pharm Res Commun 16:831–844

    Article  CAS  Google Scholar 

  11. Sekikawa I (1958) Bull Chem Soc Jpn 31:252–254

    Article  CAS  Google Scholar 

  12. Ates-Alagoz Z, Alp M, Kus C, Yıldız S, Buyukbingol E, Göker H (2006) Arch Pharm Chem Life Sci 229:74–80

    Article  CAS  Google Scholar 

  13. Göker H, Boykin DW, Yıldız S (2005) Bioorg Med Chem 13:1707–1714

    Article  CAS  Google Scholar 

  14. He Y, Wu B, Yang J, Robinson D, Risen L, Ranken R, Blyn L, Sheng S, Swayze EE (2003) Bioorg Med Chem Lett 13:3253–3256

    Article  CAS  Google Scholar 

  15. Hranjec M, Starcevic K, Zamola B, Mutak S, Derek M, Karminiki-Zamola G (2002) J Antibiot 55:308–314

    CAS  Google Scholar 

  16. Tuncbilek M, Göker H, Ertan R, Eryigit R, Kendi E, Altanlar N (1997) Arch Pharm Pharm Med Chem 330:372–376

    Article  CAS  Google Scholar 

  17. Göker H, Tuncbilek M, Ayhan G, Altanlar N (1998) Farmaco 53:415–420

    Article  Google Scholar 

  18. Ayhan-Kilcigil G, Tuncbilek M, Altanlar N, Göker H (1999) Farmaco 54:562–565

    Article  CAS  Google Scholar 

  19. Göker H, Tuncbilek M, Süzen S, Kus C, Altanlar N (2001) Arch Pharm Pharm Med Chem 334:148–152

    Article  Google Scholar 

  20. Özbey S, İde S, Kendi E (1998) J Mol Struct 442:23–30

    Article  Google Scholar 

  21. Özbey S, Kendi E, Göker H, Tunçbilek M (1998) J Chem Cryst 28:461–464

    Article  Google Scholar 

  22. Kendi E, Özbey S, Göker H (1999) Acta Cryst C55:243–245

    CAS  Google Scholar 

  23. Göker H, Ayhan-Kilcigil G, Tunçbilek M, Kuş C, Ertan R, Kendi E, Özbey S, Fort M, Garcia C, Farre A (1999) J Heterocycles 51:2561–2573

    Article  Google Scholar 

  24. Özbey S, Kaynak FB, Kuş C, Göker H (2002) Acta Cryst E58:o1062–o1064

    Google Scholar 

  25. Enraf-Nonius (1994) CAD4 express software. Enraf-Nonius, Delft, The Netherlands

  26. Sheldrick GM (1997) SHELXS97. Program for the solution of crystal structure. University of Göttingen, Germany

    Google Scholar 

  27. Sheldrick GM (1997) SHELXL97. Program for the refinement of crystal structures. University of Göttingen, Germany

    Google Scholar 

  28. North ACT, Phillips DC, Mathews FS (1968) Acta Cryst A24:351–359

    Google Scholar 

  29. Farrugia LJ (1997) ORTEP-3 for windows. J Appl Cryst 30:565

    Article  CAS  Google Scholar 

Download references

Acknowledgment

The authors wish to acknowledge the support of Hacettepe University Research Fund (Project No: 0302602001).

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Authors and Affiliations

  1. Department of Physics Engineering, Hacettepe University, Beytepe, 06800, Ankara, Turkey

    F. Betül Kaynak & Süheyla Özbey

  2. Department of Pharmaceutical Chemistry, Ankara University, Tandogan, 06100, Ankara, Turkey

    Meral Tuncbilek & Mehmet Alp

Authors
  1. F. Betül Kaynak
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  2. Süheyla Özbey
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  3. Meral Tuncbilek
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  4. Mehmet Alp
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Correspondence to F. Betül Kaynak.

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Kaynak, F.B., Özbey, S., Tuncbilek, M. et al. Synthesis and crystal structure of 1-benzyl-2-(4-benzyloxyphenyl)-5,6-dichloro-1H-benzimidazole. Struct Chem 19, 477–480 (2008). https://doi.org/10.1007/s11224-008-9306-y

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  • DOI: https://doi.org/10.1007/s11224-008-9306-y

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