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Synthesis and antimicrobial activity of silicon—titanium—zinc- and silicon—titanium—boron-containing glycerohydrogels

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Abstract

Novel pharmacologically active silicon—titanium—zinc- and silicon—titanium—boron-containing glycerohydrogels were synthesized by the sol—gel method using silicon, titanium, zinc, and boron glycerolates as biocompatible precursors. The compositions and structural features of the hydrogels were studied by transmission electron microscopy, scanning electron microscopy, IR spectroscopy, atomic emission spectrometry, and elemental analysis methods. The disperse phase and liquid water—glycerol medium of the hydrogels were isolated by cold exhaustive extraction with ethanol and characterized. The 3D polymeric network of the gels is formed by the products of hydrolysis and subsequent (co)condensation of silicon-/silicon—boron-containing precursors. Titanium and zinc glycerolates undergo no hydrolytic transformations under gelation conditions and exist in the cells of the 3D polymeric network in the form of amorphous nanoparticles that are not linked to the network by covalent bonds. Models of the structures were proposed. The gels are characterized by antimicrobial activity, which is more pronounced for the silicon—titanium—boron-containing gel, and they can be considered as promising drugs for topical treatment prepared by the simple, environmentally friendly, and cost-effective method.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, 22 ul. S. Kovalevskoi, 620990, Ekaterinburg, Russian Federation

    T. G. Khonina, E. Yu. Nikitina, E. V. Shadrina, I. N. Ganebnykh, M. S. Valova & O. N. Chupakhin

  2. Ural State Agrarian University, 42 ul. K. Libknekhta, 620075, Ekaterinburg, Russian Federation

    T. G. Khonina

  3. Ural Research Institute for Dermatology, Venereology and Immunopathology, 8 ul. Shcherbakova, 620076, Ekaterinburg, Russian Federation

    N. P. Evstigneeva & M. M. Kokhan

  4. Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    M. S. Karabanalov, D. K. Kuznetsov & O. N. Chupakhin

Authors
  1. T. G. Khonina
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  2. E. Yu. Nikitina
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  3. E. V. Shadrina
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  4. N. P. Evstigneeva
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  6. I. N. Ganebnykh
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  7. M. S. Karabanalov
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  8. D. K. Kuznetsov
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  9. M. S. Valova
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  10. O. N. Chupakhin
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Correspondence to T. G. Khonina.

Additional information

Dedicated to Academician of the Russian Academy of Sciences V. N. Charushin on the occasion of his 70th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 967–974, May, 2021.

The studies were carried out using the equipment of the Center for Joint Use “Spectroscopy and Analysis of Organic Compounds” of the I. Ya. Postovsky Institute of Organic Synthesis (Ural Branch of the Russian Academy of Sciences) and Ural Federal University (Laboratory for Modern Methods of Analysis and Properties of Materials and Nanomaterials).

This work was carried out in terms of plans of the research work and state assignment for 2021 (state registration No. AAAA-A19-119011790134-1). The pharmacological studies were carried out in terms of the state assignment for 2021 (state registration No. AAAA-A19-119011790130-3).

This work does not involve human participants and animal subjects.

The authors declare that there is no conflict of interest in financial or any other sphere.

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Khonina, T.G., Nikitina, E.Y., Shadrina, E.V. et al. Synthesis and antimicrobial activity of silicon—titanium—zinc- and silicon—titanium—boron-containing glycerohydrogels. Russ Chem Bull 70, 967–974 (2021). https://doi.org/10.1007/s11172-021-3174-7

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  • DOI: https://doi.org/10.1007/s11172-021-3174-7

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