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Synthesis and properties of biologically active silicon,zinc—glycerohydrogel

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Abstract

A new combined bioactive silicon,zinc—glycerohydrogel was prepared by the sol—gel method using silicon and zinc glycerolates as precursors. The disperse phase of the hydrogel was isolated by exhaustive cold extraction and characterized by X-ray diffraction analysis, scanning electron microscopy, atomic emission spectrometry, IR spectroscopy, and elemental analysis; and the model of the structure was proposed. The studied gel was shown to exhibit pronounced wound-healing and regenerative activity, possesses moderate antibacterial effect, and can be recommended for deeper studies with the purpose of including in medical practice.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoy, 620041, Ekaterinburg, Russian Federation

    O. N. Chupakhin, A. N. Bondarev, I. N. Shtan’ko, T. G. Khonina & E. V. Shadrina

  2. Ural Federal University named after the First President of Russia B. N. Yeltsin, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    O. N. Chupakhin

  3. Institute of Solid State Chemistry, Ural Branch of the Russian Academy of Sciences, 91 ul. Pervomaiskaya, 620990, Ekaterinburg, Russian Federation

    E. A. Bogdanova

  4. Ministry of Health Protection, Ural State Medical University, 3 ul. Repina, 620219, Ekaterinburg, Russian Federation

    L. P. Larionov

Authors
  1. O. N. Chupakhin
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  2. A. N. Bondarev
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  3. I. N. Shtan’ko
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  4. T. G. Khonina
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  5. E. V. Shadrina
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  6. E. A. Bogdanova
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  7. L. P. Larionov
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Corresponding author

Correspondence to I. N. Shtan’ko.

Additional information

Based on the materials of the First Russian Conference on Medicinal Chemistry (MedChem Russia-2013) with International participation (September 8–12, 2013, Moscow).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1219–1224, May, 2014.

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Chupakhin, O.N., Bondarev, A.N., Shtan’ko, I.N. et al. Synthesis and properties of biologically active silicon,zinc—glycerohydrogel. Russ Chem Bull 63, 1219–1224 (2014). https://doi.org/10.1007/s11172-014-0577-8

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  • DOI: https://doi.org/10.1007/s11172-014-0577-8

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