Skip to main content
SpringerLink
Log in

Multifunctional polymer dispersions for biomedical assays obtained by heterophase radical polymerization

  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

Methods for the preparation of multifunctional dispersions of polymer particles (DPP) in the course of free radical heterophase polymerization, which provides careful control of both macromolecular and colloidal properties, are considered. Approaches that, according to the polymerization technique, make it possible to control the particle diameter and shape, particle size distribution, colloidal stability, morphology, surface chemistry and functionality, as well as the formation of organo-inorganic hybrid particles, are demonstrated. The possibilities of DPP application in homogeneous and heterogeneous assays and cell labelling are reviewed. The use of DPP leads to decrease the reaction scales and costs and to increase the speed, sensitivity, selectivity, and reproducibility of assays.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Colvin, A. Smolka, M. Chang, A. Rembaum, Microspheres: Medical and Biological Applications, Eds A. Rembaum, Z. Tokes, CRC Press, 1988,242.

  2. S. Reculusa, C. Poncet-Legrand, S. Ravaine, C. Mingotaud, E. Duguet, E. Bourgeat-Lami, Chem. Mater., 2002, 14, 2354.

    Article  CAS  Google Scholar 

  3. A. Tuncel, M. Tuncel, B. Salih, J. Appl. Polym. Sci., 1999, 71, 2271.

    Article  CAS  Google Scholar 

  4. P. J. Colver, C. A. L. Colard, S. A. F. Bon, J. Am. Chem. Soc., 2008, 130, 16850.

    Article  CAS  PubMed  Google Scholar 

  5. H. Liu, J. Guo, L. Jin, W. Yang, C. Wang, J. Phys. Chem. B, 2008, 112, 3315.

    Article  CAS  PubMed  Google Scholar 

  6. L. B. Bangs, Pure Appl. Chem., 1996, 68, 1873.

    Article  CAS  Google Scholar 

  7. A. Bajaj, O. R. Miranda, I.-B. Kim, R. L. Phillips, D. J. Jerry, U. H. F. Bunz, V. M. Rotello, Proc. Natl. Acad. Sci., 2009, 106, 10912.

    Article  PubMed  PubMed Central  Google Scholar 

  8. R. Arshady, Biomaterials, 1993, 14,5.

    Article  CAS  PubMed  Google Scholar 

  9. US Pat. 7323305 B2, 2008.

  10. H. Harma, Particle Technologies in Diagnostics, TEKES, Helsinki, 2002,126.

    Google Scholar 

  11. A. Samanta, I. L. Medintz, Nanoscale, 2016, 8, 9037.

    Article  CAS  PubMed  Google Scholar 

  12. A. Lendlein, M. Rehahn, M. R. Buchmeiser, R. Haag, Macromol. Rapid Commun., 2010, 31, 1487.

    Article  CAS  PubMed  Google Scholar 

  13. A. M. Horgan, J. D. Moore, J. E. Noble, G. J. Worsley, Trends Biotechnol., 2010, 28,485.

    Article  CAS  PubMed  Google Scholar 

  14. C. Pichot, T. Delair, H. Kawaguchi, in Chemistry and Technology of Emulsion Polymerisation, Ed. A. M. van Herk, Chichester, 2013, p.283.

  15. A. N. Generalova, V. P. Zubov, Colloids Surfaces B Biointerfaces, 2018, 166,303.

    Article  CAS  PubMed  Google Scholar 

  16. V. Sinha, A. Singla, S. Wadhawan, R. Kaushik, R. Kumria, K. Bansal, S. Dhawan, Int. J. Pharm., 2004, 274,1.

    Article  CAS  PubMed  Google Scholar 

  17. C. Schmidt, R. Boodmeier, J. Control. Release, 1999, 57,115.

    Article  CAS  PubMed  Google Scholar 

  18. S. V. Kurmaz, N. A. Obrazcova, A. A. Balakina, A. A. Terent´eva, Russ. Chem. Bull., 2016, 65, 2097.

    Article  CAS  Google Scholar 

  19. N. A. Peppas, J. Panyam, V. Labhasetwar, Adv. Drug Del. Rev., 2012, 64,61.

    Article  CAS  Google Scholar 

  20. Eur. Pat. 0274961, 1988.

  21. W. R. Gombotz, S. F. Wee, Adv. Drug Deliv. Rev., 2012, 64,194.

    Article  Google Scholar 

  22. H.-M. Buchhammer, M. Mende, M. Oelmann, Colloids Surfaces A Physicochem. Eng. Asp., 2003, 218,151.

    Article  CAS  Google Scholar 

  23. R. Arshady, Colloid Polym. Sci., 1992, 270,717.

    Article  CAS  Google Scholar 

  24. K. Tauer, Latex Particles, Ed. F. Caruso, Wiley-VCH Verlag, Wenheim, 2004,580.

  25. A. Elaissari, Colloidal Polymers. Synthesis and Characterization, Marcel Dekker, New York, 2003,464.

    Book  Google Scholar 

  26. R. M. Fitch, in Macromolecules, Eds H. Benoit, P. Rempp, Pergamon Press, 1982,52.

  27. Y. G. Durant, R. Carrier, D. C. Sundberg, Polym. React. Eng., 2003, 11,433.

    Article  CAS  Google Scholar 

  28. M. A. Khan, S. P. Armes, Adv. Mater., 2000, 12,671.

    Article  CAS  Google Scholar 

  29. S. V. Zhachenkov, G. I. Litvinenko, V. A. Kaminskii, P. Y. Il´menev, A. V. Pavlov, V. V. Gur´yanova, I. A. Gritskova, A. N. Pravednikov, Polym. Sci. USSR, 1985, 27, 1400.

    Article  Google Scholar 

  30. D. I. Shragin, I. A. Gritskova, V. V. Kopylov, E. V. Milushkova, L. A. Zlydneva, S. M. Levachev, Silicon, 2015, 7,217.

    Article  CAS  Google Scholar 

  31. K. Sato, M. Tokeshi, T. Odake, H. Kimura, T. Ooi, M. Nakao, T. Kitamori, Anal. Chem., 2000, 72, 1144.

    Article  CAS  PubMed  Google Scholar 

  32. D. Urban, K. Takamura, Polymer Dispersions and Their Industrial Applications, Wiley-VCH Verlag, New York, 2002,242.

    Book  Google Scholar 

  33. R. Arshady, A. Ledwith, React. Polym. Ion Exch. Sorbents, 1983, 1,159.

    Article  CAS  Google Scholar 

  34. R. Arshady, Adv. Mater., 1991, 3,182.

    Article  CAS  Google Scholar 

  35. W. D. Harkins, J. Am. Chem. Soc., 1947, 69, 1428.

    Article  CAS  PubMed  Google Scholar 

  36. S. S. Medvedev, Kinetika i mekhanizm obrazovaniya i prevrashcheniya makromolekul [Kinetics and Mechanism of Formation and Transformation of Macromolecules], Moscow, Nauka, 1968, 324 pp. (in Russian).

    Google Scholar 

  37. J. W. Vanderhoff, J. Polym. Sci. Polym. Symp., 2007, 72,161.

    Article  Google Scholar 

  38. F. K. Hansen, J. Ugelstad, J. Polym. Sci. Polym. Chem. Ed., 1978, 16, 1953.

    Article  CAS  Google Scholar 

  39. G. A. Simakova, V. A. Kaminskii, I. A. Gritskova, A. N. Pra vednikov, Dokl. AN SSSR, 1984, 276, 151 [Dokl. Chem. (Engl. Transl.), 1984, 276] (in Russian).

    CAS  Google Scholar 

  40. J. Ugelstad, M. S. El-Aasser, J. W. Vanderhoff, J. Polym. Sci., Polym. Lett. Ed., 1973, 11,503.

    Article  CAS  Google Scholar 

  41. K. Landfester, Adv. Mater., 2001, 10,765.

    Article  Google Scholar 

  42. P. J. Blythe, E. D. Sudol, M. S. El-Aasser, Macromol. Symp., 2000, 150,179.

    Article  CAS  Google Scholar 

  43. K. Landfester, Macromol. Rapid Comm., 2001, 22,896.

    Article  Google Scholar 

  44. F. Candau, in Handbook of Microemulsion Science and Technology, Eds P. Kumar, K. L. Mittal, Marcel Dekker, New York, 1999,679.

  45. I. D. Robb, Microemulsions, Plenum Publishers, New York, 1982.202.

    Book  Google Scholar 

  46. D. Myers, Surfactant Science and Technology, VCH Publishers, New York, 1988,351.

    Google Scholar 

  47. K. Tauer, H. Müller, C. Schellenberg, L. Rosengarten, Colloids Surfaces A Physicochem. Eng. Asp., 1999, 153,143.

    Article  CAS  Google Scholar 

  48. K. E. J. Barrett, Br. Polym. J., 1973, 5,259.

    Article  CAS  Google Scholar 

  49. C. K. Ober, K. P. Lok, M. L. Hair, J. Polym. Sci. Polym. Lett. Ed., 1985, 23,103.

    Article  CAS  Google Scholar 

  50. S. Kawaguchi, K. Ito, in Polymer Particles. Advances in Polymer Science, Ed. M. Okubo, Springer, Berlin, Heidelberg, 2005,299.

  51. G. L. Li, H. Möhwald, D. G. Shchukin, Chem. Soc. Rev., 2013, 42, 3628.

    Article  CAS  PubMed  Google Scholar 

  52. K. Li, H. D. H. Stöver, J. Polym. Sci., Part A Polym. Chem., 1993, 31, 3257.

    Article  CAS  Google Scholar 

  53. A. M. van Herk, in Chemistry and Technology of Emulsion Polymerisation, John Wiley & Sons Ltd, Oxford, 2013,23.

    Book  Google Scholar 

  54. K. Matyjaszewski, J. Polym. Sci., Part A Polym. Chem., 1987, 25,765.

    Article  CAS  Google Scholar 

  55. K. Matyjaszewski, Controlled Radical Polymerization, ACS Sympos., 1998, 258; DOI: 10.1021/bk-1998-0685.ch016.

    Book  Google Scholar 

  56. B. Charleux, F. D´Agosto, G. Delaittre, in Hybrid latex particles: Preparation with (Mini)emulsion Polymerization, Eds A. van Herk, K. Landfester, Springer-Verlag, Berlin–Heidelberg, 2010,128.

  57. C. Farcet, C. Burguiere, B. Charleux, in Colloidal Polymers Synthesis and Characterization, Ed. A. Elaissar, CRC Press, 2003,41.

  58. M. F. Cunningham, Prog. Polym. Sci., 2008, 33,365.

    Article  CAS  Google Scholar 

  59. Eur. Pat. 180384 A2, 1986.

  60. J. Ugelstad, A. Berge, T. Ellingsen, R. Schmid, T.-N. Nilsen, P. C. Mørk, P. Stenstad, E. Hornes, Ø. Olsvik, Prog. Polym. Sci., 1992, 17,87.

    Article  CAS  Google Scholar 

  61. G. Vandezande, A. Rudin, J. Coat. Technol., 1994, 66,99.

    CAS  Google Scholar 

  62. D. Dendukuri, P. S. Doyle, Adv. Mater., 2009, 21, 4071.

    Article  CAS  Google Scholar 

  63. S. Sugiura, M. Nakajima, H. Itou, M. Seki, Macromol. Rapid Commun., 2001, 22,773.

    Article  CAS  Google Scholar 

  64. D. C. Sundberg, A. P. Casassa, J. Pantazopoulos, M. R. Muscato, B. Kronberg, J. Berg, J. Appl. Polym. Sci., 1990, 41, 1425.

    Article  CAS  Google Scholar 

  65. Y. C. Chen, V. Dimonie, M. S. El-Aasser, J. Appl. Polym. Sci., 1992, 45,487.

    Article  CAS  Google Scholar 

  66. Y.-C. Chen, V. L. Dimonie, O. L. Shaffer, M. S. El-Aasser, Polym. Int., 1993, 30,185.

    Article  CAS  Google Scholar 

  67. L. J. Gonzalez-Ortiz, J. M. Asua, Macromolecules, 1996, 29,383.

    Article  CAS  Google Scholar 

  68. T. Tanaka, M. Okayama, H. Minami, M. Okubo, Langmuir, 2010, 26, 11732.

    Article  CAS  PubMed  Google Scholar 

  69. C. J. McDonald, M. J. Devon, Adv. Colloid Interface Sci., 2002, 99,181.

    Article  CAS  PubMed  Google Scholar 

  70. M. Schneider, T. Pith, M. Lambla, J. Appl. Polym. Sci., 1996, 62,273.

    Article  CAS  Google Scholar 

  71. H. Huang, H. Liu, J. Polym. Sci., Part A, Polym. Chem., 2010, 48, 5198.

    Article  CAS  Google Scholar 

  72. V. Herrera, R. Pirri, J. M. Asua, J. R. Leiza, J. Polym. Sci., Part A, Polym. Chem., 2007, 45, 2484.

    Article  CAS  Google Scholar 

  73. P. A. Lovell, M. S. El-Aasser, Emulsion Polymerization and Emulsion Polymers, John Wiley & Sons Ltd., Chichester, 1997, 125–163.

    Google Scholar 

  74. I. Piirma, in Surfactant Science, Marcell Dekker, New York, 1992,122.

    Google Scholar 

  75. K. Holmberg, B. Jonsson, B. Kronberg, B. Lindman, Surfactants and Polymers in Aqueous Solution, Wiley & Sons, Chichester, 2002.

    Book  Google Scholar 

  76. J. P. Rao, K. E. Geckeler, Prog. Polym. Sci., 2011, 36,887.

    Article  CAS  Google Scholar 

  77. D. Cochin, A. Laschewsky, F. Nallet, Macromolecules, 1997, 30, 2278.

    Article  CAS  Google Scholar 

  78. P. Ni, M. Zhang, L. Ma, S. Fu, Langmuir, 2006, 22, 6016.

    Article  CAS  PubMed  Google Scholar 

  79. G. Riess, C. Labbe, Macromol. Rapid Commun., 2004, 25,401.

    Article  CAS  Google Scholar 

  80. J. Puig, E. Mendizábal, F. López-Serrano, R. G. López, in Encyclopedia of Surface and Colloid Science, Taylor & Francis, 2012,316.

    Google Scholar 

  81. K. Holmberg, Prog. Org. Coatings, 1992, 20,325.

    Article  CAS  Google Scholar 

  82. A. Montoya-Gorii, D. C. Sherrington, H. A. S. Schoonbrood, J. M. Asua, Polymer, 1999, 40, 1359.

    Article  Google Scholar 

  83. L. A. Cantarero, J. E. Butler, J. W. Osborne, Anal. Biochem., 1980, 105,375.

    Article  CAS  PubMed  Google Scholar 

  84. N. I. Prokopov, I. A. Gritskova, V. R. Cherkasov, A. E. Chalykh, Russ. Chem. Rev., 1996, 65,167.

    Article  Google Scholar 

  85. B. Emelie, C. Pichot, J. Guillot, Macromol. Chem. Phys., 1988, 189, 1879.

    Article  CAS  Google Scholar 

  86. D. Horak, F. Svec, J. M. J. Frechet, J. Polym. Sci., Part A, Polym. Chem., 1995, 33, 2329.

    Article  CAS  Google Scholar 

  87. S. Kawaguchi, A. Yekta, M. A. Winnik, J. Colloid Interface Sci., 1995, 176,362.

    Article  CAS  Google Scholar 

  88. A. N. Generalova, V. A. Oleinikov, A. Sukhanova, M. V. Artemyev, V. P. Zubov, I. Nabiev, Biosens. Bioelectron., 2013, 39,187.

    Article  CAS  PubMed  Google Scholar 

  89. R. H. Pelton, P. Chibante, Colloids and Surfaces, 1986, 20, 247.aaaaa

    Article  CAS  Google Scholar 

  90. F. D´Agosto, M.-T. Charreyre, C. Pichot, R. G. Gilbert, J. Polym. Sci., Part A Polym. Chem., 2003, 41, 1188.

    Article  CAS  Google Scholar 

  91. M. Husseman, E. E. Malmström, M. McNamara, M. Mate, D. Mecerreyes, D. G. Benoit, J. L. Hedrick, P. Mansky, E. Huang, T. P. Russell, C. J. Hawker, Macromolecules, 1999, 32, 1424.

    Article  CAS  Google Scholar 

  92. S. Tsuji, H. Kawaguchi, Langmuir, 2004, 20, 2449.

    Article  CAS  PubMed  Google Scholar 

  93. D. Wang, A. L. Rogach, F. Caruso, Nano Lett., 2002, 2,857.

    Article  CAS  Google Scholar 

  94. A. N. Generalova, V. P. Zubov, Polym. Sci., Ser. B, 2016, 58,385.

    Article  CAS  Google Scholar 

  95. C. K. Weiss, K. Landfester, in Hybrid Latex Particles. Advances in Polymer Science, Ed. L. K. van Herk, Springer, Berlin–Heidelberg, 2010,185.

  96. US Pat. 4487855 A, 1984.

  97. A. N. Generalova, B. N. Chichkov, E. V. Khaydukov, Adv. Colloid Interface Sci., 2017, 245,1.

    Article  CAS  PubMed  Google Scholar 

  98. Z. Xu, X. Hu, X. Li, C. Yi, J. Polym. Sci., Part A Polym. Chem., 2008, 46,481.

    Article  CAS  Google Scholar 

  99. F. Stoffelbach, B. Belardi, J. M. R. C. A. Santos, L. Tessier, K. Matyjaszewski, B. Charleux, Macromolecules, 2007, 40, 8813.

    Article  CAS  Google Scholar 

  100. R. G. Jones, E. S. Wilks, V. W. Metanomski, J. Kahovec, M. Hess, R. Stepto, T. Kitayama, Compendium of Polymer Terminology and Nomenclature (IUPAC Recommendations 2008), RSC Publ., 2009,464.

    Book  Google Scholar 

  101. E. Bourgeat-Lami, J. Nanosci. Nanotechnol., 2002, 2,1.

    Article  CAS  PubMed  Google Scholar 

  102. E. F. Panarin, Russ. Chem. Bull., 2017, 66, 1812.

    Article  CAS  PubMed  Google Scholar 

  103. A. N. Generalova, S. V. Sizova, V. A. Oleinikov, V. P. Zubov, M. V. Artemyev, L. Spernath, A. Kamyshny, S. Magdassi, Colloids Surfaces A, Physicochem. Eng. Asp., 2009, 342,59.

    Article  CAS  Google Scholar 

  104. B. V. Derjaguin, Discuss. Faraday Soc., 1954, 18,85.

    Article  Google Scholar 

  105. F. K. Hansen, E. Matijevic, J. Chem. Soc. Faraday Trans. 1, Phys. Chem. Condens. Phases, 1980, 76, 1240.

    CAS  Google Scholar 

  106. A. N. Generalova, V. A. Oleinikov, M. M. Zarifullina, E. V. Lankina, S. V. Sizova, M. V. Artemyev, V. P. Zubov, J. Colloid Interface Sci., 2011, 357,265.

    Article  CAS  PubMed  Google Scholar 

  107. L. Hong, A. Cacciuto, E. Luijten, S. Granick, Langmuir, 2008, 24,621.

    Article  CAS  PubMed  Google Scholar 

  108. R. F. A. Teixeira, S. A. F. Bon, in Hybrid Latex Particles, Eds A. M. van Herk, K. Landfester, 2010,19.

  109. A. Wooding, M. Kilner, D. B. Lambrick, J. Colloid Interface Sci., 1992, 149,98.

    Article  CAS  Google Scholar 

  110. K. Meguro, T. Yabe, S. Ishioka, K. Kato, K. Esumi, ull. Chem. Soc. Jpn., 1986, 59, 3019.

    Article  CAS  Google Scholar 

  111. M. Chaimberg, R. Parnas, Y. Cohen, J. Appl. Polym. Sci., 1989, 37, 2921.

    Article  CAS  Google Scholar 

  112. Z. Xu, A. Xia, C. Wang, W. Yang, S. Fu, Mater. Chem. Phys., 2007, 103,494.

    Article  CAS  Google Scholar 

  113. B. Erdem, E. D. Sudol, V. L. Dimonie, M. S. El-Aasser, Macromol. Symp., 2000, 155,181.

    Article  CAS  Google Scholar 

  114. G. Diaconu, M. Micusí k, A. Bonnefond, M. Paulis, J. R. Leiza, Macromolecules, 2009, 42, 3316.

    Article  CAS  Google Scholar 

  115. Y. Yang, C. Tu, M. Gao, J. Mater. Chem., 2007, 17, 2930.

    Article  CAS  Google Scholar 

  116. R. Aveyard, B. P. Binks, J. H. Clint, Adv. Colloid Interface Sci., 2003, 100–102,503.

    Article  CAS  Google Scholar 

  117. Y. Deslandes, J. Appl. Polym. Sci., 1987, 34, 2249.

    Article  CAS  Google Scholar 

  118. C. Wang, C. Zhang, Y. Li, Y. Chen, Z. Tong, React. Funct. Polym., 2009, 69,750.

    Article  CAS  Google Scholar 

  119. K. Chen, Y. Yang, Q. Sa, L. Shi, H. Zhao, Polymer, 2008, 49, 2650.

    Article  CAS  Google Scholar 

  120. F. Tiarks, K. Landfester, M. Antonietti, Langmuir, 2001, 17, 5775.

    Article  CAS  Google Scholar 

  121. S. Fortuna, C. A. L. Colard, A. Troisi, S. A. F. Bon, Langmuir, 2009, 25, 12399.

    Article  CAS  PubMed  Google Scholar 

  122. J. Zhang, N. Coombs, E. Kumacheva, J. Am. Chem. Soc., 2002, 124, 14512.

    Article  CAS  PubMed  Google Scholar 

  123. A. B. R. Mayer, W. Grebner, R. Wannemacher, J. Phys. Chem. B, 2000, 104, 7278.

    Article  CAS  Google Scholar 

  124. N. Kawahashi, C. Persson, E. Matijevic, J. Mater. Chem., 1991, 1,577.

    Article  CAS  Google Scholar 

  125. N. Kawahashi, H. Shiho, J. Mater. Chem., 2000, 10, 2294.

    Article  CAS  Google Scholar 

  126. F. Wen, W. Zhang, G. Wei, Y. Wang, J. Zhang, M. Zhang, L. Shi, Chem. Mater., 2008, 20, 2144.

    Article  CAS  Google Scholar 

  127. P. Zheng, X. Jiang, X. Zhang, W. Zhang, L. Shi, Langmuir, 2006, 22, 9393.

    Article  CAS  PubMed  Google Scholar 

  128. J. M. Singer, C. M. Plotz, Am. J. Med., 1956, 21,888.

    Article  PubMed  Google Scholar 

  129. W. E. Paul, Fundamental Immunology, Lippincott Williams & Wilkins, London, 2012,216.

    Google Scholar 

  130. US Pat. 4636479 A, 1987.

  131. I. Braslavsky, B. Hebert, E. Kartalov, S. R. Quake, Proc. Natl. Acad. Sci., 2003, 100, 3960.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. J. Siepmann, F. Siepmann, in Smart Colloidal Materials, Ed. W. Richtering, Springer-Verlag, Berlin, 2006,15.

  133. W. G. Wood, A. Gadow, Clin. Chem. Lab. Med., 1983, 21,789.

    Article  CAS  Google Scholar 

  134. M. Bele, J. Colloid Interface Sci., 2002, 254,274.

    Article  CAS  PubMed  Google Scholar 

  135. L. B. Bangs, in Novel Approaches in Biosensors and Rapid Diagnostic Assays, Springer US, Boston, MA, 2000,245.

    Book  Google Scholar 

  136. T. C. J. Gribnau, J. H. W. Leuvering, H. van Hell, J. Chromatogr. B Biomed. Sci. Appl., 1986, 376,175.

    Article  CAS  Google Scholar 

  137. C. P. Price, D. J. Newman, Principles and Practice of Immuno assay, Palgrave Macmillan, Hampshire, UK, 2001.

    Google Scholar 

  138. H. D. Hill, C. A. Mirkin, Nat. Protoc., 2006, 1,324.

    Article  CAS  PubMed  Google Scholar 

  139. T. A. Taton, Science, 2000, 289, 1757.

    Article  CAS  PubMed  Google Scholar 

  140. B. K. Oh, J. M. Nam, S. W. Lee, C. A. Mirkin, Small, 2006, 2,103.

    Article  CAS  PubMed  Google Scholar 

  141. V. Holzapfel, A. Musyanovych, K. Landfester, M. R. Lorenz, V. Mailnder, Macromol. Chem. Phys., 2005, 206, 2440.

    Article  CAS  Google Scholar 

  142. D. Mabey, R. W. Peeling, A. Ustianowski, M. D. Perkins, Nat. Rev. Microbiol., 2004, 2,231.

    Article  CAS  PubMed  Google Scholar 

  143. D. C. Pregibon, M. Toner, P. S. Doyle, Science, 2007, 315, 1393.

    Article  CAS  PubMed  Google Scholar 

  144. S. Fournier-Bidoz, T. L. Jennings, J. M. Klostranec, W. Fung, A. Rhee, D. Li, W. C. W. Chan, Angew. Chem., Int. Ed. Engl., 2008, 47, 5577.

    Article  CAS  Google Scholar 

  145. Y. C. Cao, Science, 2002, 297, 1536.

    Article  CAS  PubMed  Google Scholar 

  146. H. Saade, M. de L. Guillén, J. C. Romero, J. Cepeda, A. Ilyna, S. Fernández, F. J. Enríquez-Medrano, R. G. López, Int. J. Polym. Sci., 2016, 1.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997, Moscow, Russian Federation

    A. N. Generalova & V. P. Zubov

  2. Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences, 59 Leninsky prosp., 119333, Moscow, Russian Federation

    A. N. Generalova & I. M. Asharchuk

Authors
  1. A. N. Generalova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. M. Asharchuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. P. Zubov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. N. Generalova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1759–1780, October, 2018.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Generalova, A.N., Asharchuk, I.M. & Zubov, V.P. Multifunctional polymer dispersions for biomedical assays obtained by heterophase radical polymerization. Russ Chem Bull 67, 1759–1780 (2018). https://doi.org/10.1007/s11172-018-2289-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11172-018-2289-y

Key words

Search

Navigation