Russian Chemical Bulletin

, Volume 67, Issue 10, pp 1759–1780 | Cite as

Multifunctional polymer dispersions for biomedical assays obtained by heterophase radical polymerization

  • A. N. GeneralovaEmail author
  • I. M. Asharchuk
  • V. P. Zubov


Methods for the preparation of multifunctional dispersions of polymer particles (DPP) in the course of free radical heterophase polymerization, which provides careful control of both macromolecular and colloidal properties, are considered. Approaches that, according to the polymerization technique, make it possible to control the particle diameter and shape, particle size distribution, colloidal stability, morphology, surface chemistry and functionality, as well as the formation of organo-inorganic hybrid particles, are demonstrated. The possibilities of DPP application in homogeneous and heterogeneous assays and cell labelling are reviewed. The use of DPP leads to decrease the reaction scales and costs and to increase the speed, sensitivity, selectivity, and reproducibility of assays.

Key words

dispersion of polymer particles polymerization technique functionality composite particles hybrid polymer particles bioassay 


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Authors and Affiliations

  • A. N. Generalova
    • 1
    • 2
    Email author
  • I. M. Asharchuk
    • 2
  • V. P. Zubov
    • 1
  1. 1.M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussian Federation
  2. 2.Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of SciencesMoscowRussian Federation

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