Abstract
The methods of synthesis of biologically active nanostructured systems based on functional and natural polymers are reviewed. The formation of nanosystems in the process of interaction between synthetic water-soluble polyelectrolytes and amphiphilic ionic surfactants is discussed. The influence of structure and stability of these systems on their biological activity is considered. The complexation between DNA and polycations with the formation of compacted DNA molecules, and the transport of resulting complexes into the cells are discussed. The data on nanostructuring of hemoglobin using polyfunctional crosslinkers and the data on the use of the obtained nanoparticles as oxygen-transporting blood substitutes are summarized. Using nanodisperse silver stabilized with poly(vinylpyrrolidone) as an example it was demonstrated, that transferring silver into nanodisperse state results in widening its bioactivity.
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A. Helenius, K. Simons, Biochim. Biophys. Acta, 1975, 415,29.
D. A. Tirrel, Polym. Sci. Techn., 1987, 30,343.
G. E. Afinogenov, N. P. Elinov, Antiseptika v chirurgii [Antiseptics in Surgery], Medizina, Moscow, 1987, 144 pp. (in Russian).
N. A. Plate, A. E. Vasil´ev, Fisiologicheski aktivnie polimeri [Physiologically Active Polymers], Khimija, Moscow, 1986, 246 pp. (in Russian).
G. E. Afinogenov, E. F. Panarin, Antimikrobnie polimeri [Antimicrobial Polymers], Gippokrat, St. Peterburg, 1993, 264 pp. (in Russian).
M. K. Beisbekov, Ph. D. Thesis (Chemistry), Kazakhstan State University, Alma-Ata, 1985, 161 pp. (in Russian).
E. A. Bekturov, S. E. Kudaibergenov, R. E. Khamzamunina, Kationnie polimeri [Cationic Polymers], Nauka, Alma-Ata, 1986, 160 pp. (in Russian).
V. D. Pautov, Dr. Sci. Thesis (Physics and Mathematics), Institute of High Molecular Compounds RAS, St. Petersburg, 1992, 305 pp. (in Russian).
M. Rinodo, N. R. Kildeeva, V. G. Babak, Zh. Vsesoyuzn. Khim. O-va im. D. I. Mendeleeva [Mendeleev Chem. J.], 2008, 52,84.
W. Baschong, D. Huglin, T. Maier, E. Kulik, SOFW-journ., 1999, 125,22.
P. Tengamuoy, S. Sahamethapata, A. Sailasutab, A. K. Mirac, Int. J. Pharmaceutics, 2000, 197, 53.
E. F. Panarin, G. E. Afinogenov, Polimeri medizinskogo naznachenija [Medicine Polymers], A. V. Topchiev Institute of Petrochemical Synthesis RAS, Moscow, 1988, 35 pp. (in Russian).
A. K. Sirotkin, I. S. Kchetkova, E. F. Panarin, Materiali simposiuma Povishenie gotovnosti k pandemii grippa na osnove voenno-grajdanskogo sotrudnichestva [Symposium Improving Preparedness for Influenza Pandemic on the Basis of Military-civil Cooperation], 2003, St. Petersburg, 58 (in Russian).
RF Pat. 2565291; Byull. Izobret. [Invention Bull.], 2015, 29.
S. L. Tyuterev, K. V. Novojilov, E. F. Panarin, E. V. Popova, I. S. Kochetkova, V. V. Azanova, N. N. Vorobev, Russ. Agr. Sci., 2011, 37, 25.
E. F. Panarin, K. B. Grabovskaya, A. N. Suvorov, N. V. Popova, I. A. Ustinovich, P. G. Nazarov, I. S. Kochetkova, G. I. Nejinskaya, Psihopharmokol. Biol. Narkol., 2002, 3—4,422.
Pat. RF 2297151; Byull. Izobret. [Invention Bull.], 2007, 11.
Pat. RF 2521209; Byull. Izobret. [Invention Bull.], 2014, 18.
S. L. Tyuterev, E. F. Panarin, K. V. Novojilov, E. V. Popova, L. K. Hazkevich, I. S. Kochetkova, T. B. Dorofeeva, A. M. Lazarev, V. V. Azanova, Plant Protection News, 2002, 3.
S. L. Tyuterev, E. F. Panarin, E. V. Popova, Materials of International Scientific and Practical Conf. Devoted to the 40th Aniversary of the Institute of Plant Protection, (Minsk, July 5—8, 2011), Minsk, 2011, p.790.
E. V. Anufrieva, E. F. Panarin, V. D. Pautov, G. V. Semisotov, M. V. Solovskii, Polymer Sci. USSR, 1977, 19, 1529.
E. F. Panarin, V. V. Kopeikin, Polymer Sci., Ser. C, 2002, 44,185.
V. V. Kopeikin, A. I. Kipper, Polymer Sci., Ser. B, 2001, 43,185.
V. V. Kopeikin, Dr. Sci. Thesis (Chemistry), Institute of High Molecular Compounds RAS, St. Petersburg, 1999, 218 pp. (in Russian).
E. F. Panarin, V. V. Kopeikin, V. N. Konyuchov, T. M. Tokhmetov, Vestnik Selkhoz. Nauki [Agr. Sci. Bull], 1991, 6, 108 (in Russian).
RF Pat. 2073461; Byull. Izobret. [Invention Bull.], 1995,5.
RF Pat. 2050141; Byull. Izobret. [Invention Bull.], 1995,35.
E. F. Panarin, V. V. Kopeikin, V. N. Konyuchov, T. M. Tochmetov, O. N. Savchenko, Vestnik Selkhoz. Nauki [Agr. Sci. Bull.], 1991, 1, 136 (in Russian).
S. E. Serdyuk, V. E. Gmiro, Fiziolog. Zhourn. im. I. M. Sechenova [I. M. Sechenov Physiol. J.], 1995, 81, 40 (in Russian).
RF Pat. 2088233; Byull. Izobret. [Invention Bull.], 1987, 24.
RF Pat. 2108789; Byull. Izobret. [Invention Bull.], 1998, 11.
RF Pat. 2120287; Byull. Izobret. [Invention Bull.], 1998, 29.
RF Pat. 2085074; Byull. Izobret. [Invention Bull.], 1997,17.
G. T. Nabel, Proc. Natl. Acad. Sci. USA, 1999, 96,324.
B. L. Davidson, E. D. Allen, K. F. Kozarsky, Nature Genet., 1993, 3,219.
E. J. Boviatsis, M. Chase, M. X. Wei, Hum. Gene. Ther., 1994, 5,183.
A. E. Smith, Ann. Rev. Microbiol., 1995, 49,807.
J. Behr, B. Demeniex, J. Loefler, T. Perez-Mutul, Proc. Nat. Acad. Sci. USA, 1986, 86, 6982.
A. Rolland, P. Felgner, Adv. Drug. Deliv. Rev., 1998, 30,1.
D. A. Balazs, W. T. Godley, J. Drug. Deliv., 2011, ID 326497, 12 p.
G. D. Schmidt-Wolf, J. G. H. Schmidt-Wolf, Trend. Mol. Med., 2003, 9,67.
A. V. Kabanov, V. A. Kabanov, Bioconjug. Chem., 1995, 24, 4495.
M. A. Wolfert, P. R. Dask, O. V. Nasarova, D. Oupicky, D. Seymour, L. W. Smart, S. Stroholm, K. Ubrich, Biocojug. Chem., 1999, 10, 993.
A. Yu. Ershov, A. I. Kipper, S. V. Valueva, O. V. Nazarova, Yu. I. Zolotova, E. F. Panarin, Russ. J. Phys. Chem., 2010, 84,831.
S. E. Eldred, M. R. Pancost, K. M. Otte, D. Rosema, S. S. Gelman, Bioconjug. Chem., 2005, 16,694.
A. Akinc, M. Thomas, A. M. Klibanov, R. Lauser, J. Gen. Med., 2005, 7,657.
A. V. Slita, N. A. Kasyanenko, O. V. Nasarova, I. I. Gavrilova, E. M. Eropkina, A. K. Sirotkin, T. D. Smirnova, O. I. Kiselev, E. F. Panarin, J. Biotechnol., 2007, 127,679.
N. A. Kasyanenko, L. A. Lisakova, B. A. Dribinsky, Yu. I. Zolotova, O. V. Nazarova, E. F. Panarin, Polymer Sci., Ser. C, 2012, 54,57.
N. A. Kasyanenko, N. B. Zakharova, D. A. Muchin, A. V. Slita, O. V. Nasarova, E. A. Leonteva, E. F. Panarin, Biophysics, 2008, 53,31.
V. B. Morris, C. P. Sharma, Int. J. Pharmaceutics, 2010, 384,176.
N. A. Kasyanenko, V. Bakulev, I. Perevyazko, T. Nekrasova, O. Nasarova, A. Slita, Y. Solotova, E. Panarin, J. Biotechnol., 2016, 236,78.
P. M. Ness, M. M. Cushing, Arch. Pathol. Lab. Med., 2007, 131,734.
G. R. Ivanizky, Biophysics, 2001, 46, 3.
S. I. Vorobev, Khim.-Farm. Zhurn., 2009, 43, 30 [Pharm. Chem. J. (Engl. Transl.), 2009, 43].
R. Winslow, Blood Substitutes, San Diego, Academic Press, 2006.
G. Ya. Rozenberg, K. N. Makarov, Zh. Vseoyuz. Khim. O-va im. D. I. Mendeleeva [Mendeleev Chem. J.], 1985, 30,387.
W. R. Amberson, Biol. Rev., 1937, 12,48.
J. G. Riess, Chem. Rev., 2001, 101, 2797.
E. A. Selivanov, N. N. Pshenkina, E. V. Murzina, G. A. Safronov, M. D. Khanevich, V. A. Sarichev, Med. Akad. Zh.. [Medical Acad. J.], 2011, 11, 49 (in Russian).
N. P. Kuznetsova, E. F. Panarin, L. R. Gudkin, R. N. Mishaeva, Russ. Chem. Bull., 2013, 62,918.
R. Winslow, L. Djordjevich, J. F. Miller, Exp. Hematol., 1980, 8,584.
N. P. Kuznetsova, R. N. Mishaeva, G. V. Samsonov, Polymer Sci., Ser. B, 1987, 28,10.
R. N. Mishaeva, N. P. Kuznetsova, L. R. Gudkin, S. I. Klenin, G. V. Samsonov, Pharm. Chem. J., 1992, 26,36.
N. P. Kuznetsova, R. N. Mishaeva, L. R. Gudkin, G. V. Samsonov, J. Microcapsulation, 1997, 14,437.
R. Benesh, S. Kwong, R. Sweetharama, J. M. Manning, J. Biol. Chem., 1982, 257, 1320.
R. Benesh, S. Kwong, Biophys. Res. Commun, 1988, 63, 1123.
N. Shibayma, K. Jmai, H. Hirata, H. Hiraiwa, H. Morimoto, S. Saigo, Biochemistry, 1991, 30, 8158.
E. Bucci, A. Razyanska, B. Urbaitis, J. Biol. Chem., 1989, 264, 6191.
T. M. S. Chang, J. Wong, Can. J. Biochem., 1977, 55,398.
H. Sakai, M. Yuasa, H. Onuma, S. Takeoka, E. Tsuchida, Bioconjug. Chem., 2000, 11,56.
K. Ajisaka, Y. Iwashita, Biochem. Biophys. Res. Commun., 1980, 97, 1076.
K. Schmidt, Klin. Wochenschr., 1979, 57, 1169.
N. P. Kuznetsova, L. R. Gudkin, G. V. Samsonov, Bioorg. Khim. [Sov. J. Bioorg. Chem.], 1990, 16, 41 (in Russian).
N. P. Kuznetsova, L. R. Gudkin, R. N. Mishaeva, Biochemistry (Moscow), 1996, 61,495.
L. R. Gudkin, N. P. Kuznetsova, Russ. J. Appl. Chem., 1997, 70,820.
N. P. Kuznetsova, L. R. Gudkin, R. N. Mishaeva, E. F. Panarina, I. M. Bistrova, E. A. Selivanov, Dokl. Chem., 2002, 386, 268.
E. A. Selivanov, G. A. Safronov, D. M. Khanevich, O. N. Skryabin, Transfuziologija [Transfusion], 2008, 9, 68 (in Russian).
A. Schubert, R. J. Przylevsky, I. F. Eidit, Anesth. Analg., 2003, 97,323.
C. P. Stowell, I. Levin, B. D. Spiess, R. M. Winslow, Transfusion, 2001, 41,287.
I. S. Iahr, N. Varma, J. Drugs, 2004, 7,478.
Y. Jia, A. T. Alaysh, Biochem. Biophys. Acta, 2009, 1794, 1234.
T. M. Chang, Crit. Care Clin., 2009, 25,373.
N. Wong, T. M. Chang, Biotechnol, 2007, 35,481.
Z. Wang, G. Niu, X. Y. Chen, Pharm. Res., 2016, 13, 1358.
M. Callari, J. R. Aldrich-Wright, P. L. de Sansa, M. N. Stensel, Prog. Polym. Sci., 2014, 39, 1614.
Yi. Yan, T. Zhang, L. Ren, Ch. Tang, Chem. Soc. Rev., 2016, 45, 5232.
V. V. Kopeikin, E. F. Panarin, Dokl. Chem., 2002, 386, 268.aaa
M. Ray, A. Yadav, A. Gade, Biotechnol. Adv., 2009, 27, 76.aaa
E. A. Bekturov, S. E. Kudaibergenov, A. K. Zharmagambetova, R. M. Iskhanov, Zh. E. Ibraeva, S. A. Shmanov, Polimer protektirovannie nanochastizi metallov [Polymer Protected Metal Nanoparticles], Alma-Ata, 2010, 213 pp. (in Russian).
T. N. Nekrasova, Yu. I. Zolotova, O. V. Nazarova, M. L. Levit, E. I. Suvorova, A. K. Sirotkin, Yu. G. Baklagina, E. V. Didenko, V. D. Pautov, E. F. Panarin, Dokl. Chem., 2012, 446, 212.
A. A. Sarimsakov, Kh. E. Yunusov, S. Sh. Rashidova, Nanoserebro, perspektivi nanotexnologii v sozdanii lekarstvennix polimerov na ego osnove [Nanosilver, Nanotechnology Perspectives in Creation of Drugs], Tashkent, 2013, 229 pp. (in Russian).
RF Pat. 2108789; Byull. Izobret. [Invention Bull.], 1998, 11.
RF Pat. 2094056; Byull. Izobret. [Invention Bull.], 1997, 30.
S. E. Serdyuk, V. E. Gmiro, V. V. Kopeikin, E. F. Panarin, Primenenie preparatov serebra v medizine [Application of Silver Formulations in Medicine], IKI SO RAMS, Novosibirsk, 1995, 4, 146.
O. A. Pisarev, A. V. Titova, L. N. Borovikova, A. I. Kipper, T. M. Voroshilova, E. F. Panarin, Russ. Chem. Bull., 2016, 65,790.
M. Tsuji, S. Hikmo, Y. Sano, N. Horigowe, Chem. Lett., 2009, 38,518.
V. V. Kopeikin, S. V. Valueva, A. N. Kipper, L. N. Borovikova, A. P. Filippov, Vysok. Soed., Ser. A, [Polymer Sci., Ser. A] 2003, 45, 615 (in Russian).
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1812—1820, October, 2017.
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Panarin, E.F. Biologically active polymer nanosystems. Russ Chem Bull 66, 1812–1820 (2017). https://doi.org/10.1007/s11172-017-1952-z
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DOI: https://doi.org/10.1007/s11172-017-1952-z