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Effect of natural polysaccharides and oligosaccharides on the permeability of cell membranes

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Abstract

Glycyrrhizic acid, arabinogalactan, and β-cyclodextrin are capable of forming complexes with various drug compounds significantly enhancing their solubility and bioavailability. To elucidate the mechanism of action of oligo- and polysaccharides, the exchange time of transporting formate ions through the membrane of myeloblastic leukemia cells (K562) was measured by NMR spectroscopy with the addition of paramagnetic ions. It was found that glycyrrhizic acid and arabinogalactan substantially increased the membrane permeability.

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Authors and Affiliations

  1. V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, 3 ul. Institutskaya, 630090, Novosibirsk, Russian Federation

    O. Yu. Selyutina, I. E. Apanasenko & N. E. Polyakov

  2. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 prosp. Akad. Lavrent´eva, 630090, Novosibirsk, Russian Federation

    A. G. Shilov

  3. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    S. S. Khalikov

Authors
  1. O. Yu. Selyutina
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  2. I. E. Apanasenko
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  3. A. G. Shilov
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  4. S. S. Khalikov
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  5. N. E. Polyakov
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Correspondence to O. Yu. Selyutina.

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Dedicated to Academician of the Russian Academy of Sciences R. Z. Sagdeev on the occasion of his 75th anniversary.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0129—0135, January, 2017.

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Selyutina, O.Y., Apanasenko, I.E., Shilov, A.G. et al. Effect of natural polysaccharides and oligosaccharides on the permeability of cell membranes. Russ Chem Bull 66, 129–135 (2017). https://doi.org/10.1007/s11172-017-1710-2

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  • DOI: https://doi.org/10.1007/s11172-017-1710-2

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