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Effect of glycyrrhizic acid on hemolysis of red blood cells and properties of cell membranes

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Abstract

Due to amphiphilic properties, glycyrrhizic acid is capable of forming water-soluble conjugates with a wide variety of hydrophobic pharmaceutical compounds. This results in a significant reduction in the therapeutic dose of the drugs. To enlighten the molecular and cellular mechanisms of the observed effects, the influence of glycyrrhizic acid on the properties of cell membranes was studied by physical methods. Glycyrrhizic acid was found to increase the elasticity of human erythrocyte membranes and slow down the process of hemolysis.

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Authors and Affiliations

  1. V. V. Voevodskii Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, 3 ul. Akad. Rzhanova, 630090, Novosibirsk, Russian Federation

    O. Yu. Selyutina & N. E. Polyakov

  2. Novosibirsk State University, 2 ul. Pirogova, 630090, Novosibirsk, Russian Federation

    O. Yu. Selyutina

  3. State Research Center of Virology and Biotechnology VECTOR, 630559, Koltsovo, Novosibirsk region, Russian Federation

    D. V. Korneev & B. N. Zaitsev

Authors
  1. O. Yu. Selyutina
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  2. N. E. Polyakov
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  3. D. V. Korneev
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  4. B. N. Zaitsev
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Corresponding author

Correspondence to O. Yu. Selyutina.

Additional information

Based on the materials of the First Russian Conference on Medicinal Chemistry (“MedChem Russia-2013”) with International Participation (September 8–12, 2013, Moscow).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1201–1204, May, 2014.

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Selyutina, O.Y., Polyakov, N.E., Korneev, D.V. et al. Effect of glycyrrhizic acid on hemolysis of red blood cells and properties of cell membranes. Russ Chem Bull 63, 1201–1204 (2014). https://doi.org/10.1007/s11172-014-0573-z

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  • DOI: https://doi.org/10.1007/s11172-014-0573-z

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