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Membrane-modifying activity of glycyrrhizic acid

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Abstract

Owing to amphiphilicity, glycyrrhizic acid is capable of forming complexes with a variety of hydrophobic therapeutic compounds. This is accompanied by a significant decrease in the therapeutic dose of the drug. In addition, glycyrrhizic acid has a strong influence on the permeability and elasticity of cell membranes. To elucidate the molecular and cellular mechanisms of the effects observed, the effect of glycyrrhizic acid on the dynamics of lipids inside the membrane was investigated by NMR relaxation. It was found that glycyrrhizic acid can be incorporated into the membrane increasing the mobility of lipids.

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Authors and Affiliations

  1. V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, 3 ul. Institutskaya, 630090, Novosibirsk, Russian Federation

    O. Yu. Selyutina, I. E. Apanasenko & N. E. Polyakov

  2. Novosibirsk State University, 2 ul. Pirogova, 630090, Novosibirsk, Russian Federation

    O. Yu. Selyutina & I. E. Apanasenko

Authors
  1. O. Yu. Selyutina
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  2. I. E. Apanasenko
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  3. N. E. Polyakov
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Correspondence to O. Yu. Selyutina.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1555–1559, July, 2015.

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Selyutina, O.Y., Apanasenko, I.E. & Polyakov, N.E. Membrane-modifying activity of glycyrrhizic acid. Russ Chem Bull 64, 1555–1559 (2015). https://doi.org/10.1007/s11172-015-1040-1

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  • DOI: https://doi.org/10.1007/s11172-015-1040-1

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