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Synthesis of pharmacologically active hydrogels based on combined silicon and titanium polyolates

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Abstract

The target synthesis of new biologically active hydrogels based on combined silicon and titanium polyolates was carried out. The optimum conditions for hydrogel formation and their composition were determined. The type of hydrogels and mechanisms of gelation depend on the nature of polyols: gels based on combined silicon and titanium polyethylene glycolates are polymeric and formed via the polycondensation mechanism, whereas gels based on combined silicon and titanium glycerolates are colloidal and formed via the coagulation-condensation mechanism. The combined hydrogels based on silicon dimethyl glycerolates and titanium tetraglycerolate exhibit enhanced transcutaneous, wound healing, and regenerating activity.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoy, 620041, Ekaterinburg, Russian Federation

    M. V. Ivanenko, T. G. Khonina & O. N. Chupakhin

  2. Ural Federal University named after the First President of Russia B. N. Eltsyn, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    O. N. Chupakhin & A. P. Safronov

  3. Ural State Medical Academy, Ministry of Health Protection and Social Development, 3 ul. Repina, 620219, Ekaterinburg, Russian Federation

    L. P. Larionov & R. R. Sakhautdinova

  4. Institute of Electrophysics, Ural Branch of the Russian Academy of Sciences, 106 ul. Amundsena, 620016, Ekaterinburg, Russian Federation

    A. P. Safronov

Authors
  1. M. V. Ivanenko
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  2. T. G. Khonina
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  3. O. N. Chupakhin
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  4. L. P. Larionov
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  5. R. R. Sakhautdinova
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  6. A. P. Safronov
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Corresponding author

Correspondence to M. V. Ivanenko.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2146–2154, November, 2012.

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Ivanenko, M.V., Khonina, T.G., Chupakhin, O.N. et al. Synthesis of pharmacologically active hydrogels based on combined silicon and titanium polyolates. Russ Chem Bull 61, 2163–2171 (2012). https://doi.org/10.1007/s11172-012-0303-3

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  • DOI: https://doi.org/10.1007/s11172-012-0303-3

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