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Three-component condensation of 3-aminothiophene-2-carboxylic acid derivatives with aldehydes and Meldrum’s acid

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Russian Chemical Bulletin Aims and scope

A convenient method was developed for the synthesis of the previously unknown substituted 6,7-dihydro-4H-thieno[3,2-b]pyridin-5-ones based on the three-component condensation of 3-aminothiophenes, Meldrum’s acid, and aromatic aldehydes. 3-Aminothiophenes are easily formed in situ by decarboxylation of 3-aminothiophene-2-carboxylic acids in an acidic medium. Sodium salts of the latter acids were prepared by alkaline hydrolysis of the corresponding available esters.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    B. V. Lichitsky, R. M. Belyi, A. N. Komogortsev, A. A. Dudinov & M. M. Krayushkin

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  1. B. V. Lichitsky
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  2. R. M. Belyi
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  3. A. N. Komogortsev
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  4. A. A. Dudinov
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  5. M. M. Krayushkin
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Correspondence to M. M. Krayushkin.

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On the occasion of the 75th anniversary of the foundation of the N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 382–386, February, 2009.

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Lichitsky, B.V., Belyi, R.M., Komogortsev, A.N. et al. Three-component condensation of 3-aminothiophene-2-carboxylic acid derivatives with aldehydes and Meldrum’s acid. Russ Chem Bull 58, 387–391 (2009). https://doi.org/10.1007/s11172-010-0020-8

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  • DOI: https://doi.org/10.1007/s11172-010-0020-8

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