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Pentacoordinated diorganotin(IV) complexes of Schiff base ligands: synthesis, characterization, antimicrobial and anticancer studies

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Abstract

In the present research work, a series of diorganotin(IV) complexes formulated as R2SnL1−5 (where R is butyl, methyl, phenyl and L1−5 are Schiff base ligands which were prepared by the reaction of 2-amino-6-bromo-4-chlorophenol with the salicylaldehyde derivatives) have been synthesized. The synthesized compounds have been characterized by elemental analysis and several instrumental techniques such as FTIR, NMR (1H, 13C, and 119Sn), and mass spectrometry. The spectral results signified that the Schiff base ligands coordinated to tin atom in tridentate manner through ONO donor atoms. The Schiff base ligands and their corresponding complexes were biologically evaluated for antimicrobial efficacy against four bacterial strains and two fungal strains. The obtained results signified that phenyl substituted complexes had an edge over the butyl and methyl substituted complexes. Among all the synthesized compounds, complex 11 showed the best antimicrobial result against E. coli, P. aeruginosa and C. albicans. In addition, the anticancer activities of compounds 1–20 were evaluated against three cell lines. Complex 17 (IC50 value = 6.93 ± 1.13 µM) was found most active against the A549 cell line and showed comparable result with the standard drug paclitaxel (IC50 value = 2.98 ± 1.04 µM).

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Acknowledgements

The authors are very thankful to Dr. APJ Abdul Kalam Central Instrumentation Laboratory and Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, for providing the instrumentation and laboratory facilities.

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Authors and Affiliations

  1. Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, 125001, India

    Sonia Saroya, Sonika Asija, Yogesh Deswal & Naresh Kumar

  2. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, 173229, India

    Deepak Kumar

  3. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, India

    Deepak Kumar Jindal

  4. Department of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, 305817, India

    Prashant Puri

  5. National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, 500037, India

    Sandeep Kumar

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  1. Sonia Saroya
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Contributions

Sonia Saroya contributed to writing original draft, conceptualization, methodology; Sonika Asija contributed to supervision, formal analysis, investigations; Yogesh Deswal contributed to writing—review and editing, conceptualization, methodology; Naresh Kumar contributed to writing—review and editing, conceptualization, formal analysis; Deepak Kumar contributed to formal analysis, validation; Deepak Kumar Jindal contributed to formal analysis, validation; Prashant Puri contributed to formal analysis; Sandeep Kumar contributed to formal analysis.

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Correspondence to Sonika Asija.

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Saroya, S., Asija, S., Deswal, Y. et al. Pentacoordinated diorganotin(IV) complexes of Schiff base ligands: synthesis, characterization, antimicrobial and anticancer studies. Res Chem Intermed 48, 4671–4691 (2022). https://doi.org/10.1007/s11164-022-04826-2

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