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Survey reactivity of 2-aminopyridine and Meldrum’s acid in the presence of aryl glyoxals or aryl aldehydes; ethyl 2-(3-aryl imidazo[1,2-a]pyridin-2-yl)acetates versus ethyl 3-aryl-3-(pyridin-2-ylamino)propanoates

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Abstract

The aim of present investigation is survey reactivity of 2-aminopyridine and Meldrum’s acid in the presence of aryl glyoxals or aryl aldehydes. The ethyl 2-(3-aryl imidazo[1,2-a]pyridin-2-yl)acetates were successfully synthesized by reaction of 2-aminopyridine, Meldrum’s acid, and aryl glyoxals, while the ethyl 3-aryl-3-(pyridin-2-ylamino)propanoates were synthesized in the presence of aryl aldehydes. The reactions are performed in ethanol, catalyzed by acetic acid at reflux and microwave conditions.

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Acknowledgements

We are thankful to the Office of Graduate Studies of Vali-e-Asr University of Rafsanjan for partial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Vali-E-Asr University of Rafsanjan, 77176, Rafsanjan, Iran

    Sara Asadi, Maedeh Zebarjad, Hamidreza Masoudi & Hossein Mehrabi

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  1. Sara Asadi
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  2. Maedeh Zebarjad
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  3. Hamidreza Masoudi
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  4. Hossein Mehrabi
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Correspondence to Hossein Mehrabi.

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Asadi, S., Zebarjad, M., Masoudi, H. et al. Survey reactivity of 2-aminopyridine and Meldrum’s acid in the presence of aryl glyoxals or aryl aldehydes; ethyl 2-(3-aryl imidazo[1,2-a]pyridin-2-yl)acetates versus ethyl 3-aryl-3-(pyridin-2-ylamino)propanoates. Res Chem Intermed 48, 251–265 (2022). https://doi.org/10.1007/s11164-021-04554-z

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