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UV-protective activities of pineapple leaf extract in zebrafish embryos

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Abstract

The UV-protective activities of pineapple leaf extract in a zebrafish model have been evaluated by recording fin morphological changes. UV protective effects of pineapple leaf extract was evaluated using Kaplan–Meier analysis and Cox proportional hazards regression. The results showed that (1) the mean time of return to normal fin in the UV + pineapple leaf extract (100 and 400 μg/mL) groups are 3.90 and 2.50 days, respectively, more quickly than in the UV only group (4.12 days); (2) zebrafish fins in the pineapple leaf extract (100 and 400 μg/mL) groups are 1.44 and 4.29 times, respectively, more likely to return to recover than those in the UV only group; and (3) pineapple leaf extract has UV-absorbance abilities and significantly reduces p53 expressions and ROS generation in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis.

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Acknowledgement

This project was supported by the Ministry of Science and Technology, Republic of China, under grant number of NSC 101-2313-B-032-001-MY3.

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Authors and Affiliations

  1. Department of Chemistry, Tamkang University, No. 151 Ying-chuan Road, Tamsui, New Taipei City, 251, Taiwan

    Yau-Hung Chen & Yue-Jyun Chen

  2. Department of Life Sciences, Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan

    Chi-Yuan Chou

  3. Department of Mathematics, Tamkang University, Tamsui, New Taipei City, Taiwan

    Chi-Chung Wen

  4. Department of Applied Chemistry, National Chia-Yi University, Chia-Yi City, Taiwan

    Chien-Chung Cheng

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  1. Yau-Hung Chen
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  2. Yue-Jyun Chen
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  3. Chi-Yuan Chou
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  4. Chi-Chung Wen
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  5. Chien-Chung Cheng
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Correspondence to Yau-Hung Chen or Chien-Chung Cheng.

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Chen, YH., Chen, YJ., Chou, CY. et al. UV-protective activities of pineapple leaf extract in zebrafish embryos. Res Chem Intermed 45, 65–75 (2019). https://doi.org/10.1007/s11164-018-3632-5

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  • DOI: https://doi.org/10.1007/s11164-018-3632-5

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