Skip to main content

Advertisement

Log in

Morphology and properties of poly(lactic acid-co-glycolic acid) film improved by blending with poly(γ-benzyl l-glutamate)

  • Published:
Research on Chemical Intermediates Aims and scope Submit manuscript

Abstract

A series of poly(lactic acid-co-glycolic acid) (PLGA)/poly(γ-benzyl l-glutamate) (PBLG) blend films were prepared by casting the polymer blend solution in chloroform. Surface morphologies of the PLGA/PBLG blend films were investigated by scanning electron microscopy. Thermal, mechanical, and chemical properties of PLGA/PBLG blend films were studied by differential scanning calorimetry, thermogravimetric analysis, tensile tests, and surface contact angle tests. The results displayed that when PBLG mole content is 4 %, the tensile strength and the maximum decomposition temperature of the polymer blend film are 20.2 MPa and 359 °C, respectively, suggesting that the polymer blend film holds both a better mechanical property and a better thermal property.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. T. Paragkumar-N, D. Edith, S. Jean-Luc, Appl. Surf. Sci. 253, 2758 (2006)

    Google Scholar 

  2. J.H. Jeong, D.W. Lim, D.K. Han, T.G. Park, Colloid Surf. B. 18, 371 (2000)

    Article  CAS  Google Scholar 

  3. S.C.J. Loo, C.P. Ooi, S.H.E. Wee, Y.C.F. Boey, Biomaterials 26, 2827 (2005)

    Article  CAS  Google Scholar 

  4. S.C.J. Loo, C.P. Ooi, Y.C.F. Boey, Degrad. Stab. 83, 259 (2004)

    Article  CAS  Google Scholar 

  5. F. Ganji, M.J. Abdekhodaie, Carbohydr. Polym. 80, 740 (2010)

    Article  CAS  Google Scholar 

  6. M.L. Houchin, S.A. Neuenswander, E.M. Topp, J. Control Release 117, 413 (2007)

    Article  CAS  Google Scholar 

  7. M. Holzer, V. Vogel, W. Mantele, D. Schwartz, W. Haase, K. Langer, Eur. J. Pharm. Biopharm. 72, 428 (2009)

    Article  CAS  Google Scholar 

  8. T.W.J. Steele, C.L. Huang, E. Widjaja, F.Y.C. Boey, J.S.C. Loo, Acta Biomater. 7, 1973 (2011)

    Article  CAS  Google Scholar 

  9. E. Vey, C. Roger, L. Meehan, J. Booth, M. Claybourn, A.F. Miller, A. Saiani, Polym. Degrad. Stab. 93, 1869 (2008)

    Article  CAS  Google Scholar 

  10. N. Angelova, D. Hunkeler, Trends Biotechnol. 17, 409 (1999)

    Article  CAS  Google Scholar 

  11. N.A. Peppas, Y. Huang, M. Torres-Lugo, J.H. Ward, J. Zhang, Ann. Rev. Biomed. Eng. 2, 9 (2000)

    Article  CAS  Google Scholar 

  12. R. Langer, Ann. Biomed. Eng. 23, 101 (1995)

    Article  CAS  Google Scholar 

  13. L.G. Cima, J.P. Vacanti, C. Vacanti, J. Biomech. Eng. 113, 143 (1991)

    Article  CAS  Google Scholar 

  14. R.A. Jain, Biomaterials 21, 2475 (2000)

    Article  CAS  Google Scholar 

  15. M.J. Blanco-Preto, K. Besseghir, O. Zerbe, D. Andris, P. Orsolini, F. Heimgartner, H.P. Merkle, B. Gander, J. Control Release 67, 29 (2000)

    Article  Google Scholar 

  16. J.L. Cleland, O.L. Johnson, S. Putney, A.J.S. Jones, Adv. Drug Deliv. Rev. 28, 71 (1997)

    Article  CAS  Google Scholar 

  17. B. Bittner, C. Witt, K. Maeder, T. Kissel, J. Control Release 60, 297 (1999)

    Article  CAS  Google Scholar 

  18. A.A. Ignatius, L.E. Claes, Biomaterials 17, 831 (1996)

    Article  CAS  Google Scholar 

  19. S. Stolnik, S.E. Dunn, M.C. Garnett, Pharm. Res. 11, 1800 (1994)

    Article  CAS  Google Scholar 

  20. A. Gopferich, S.J. Peter, A. Lucke, L. Lu, A.G. Mikos, J. Biomed. Mater. Res. 46, 390 (1999)

    Article  CAS  Google Scholar 

  21. J.M. Anderson, K.M. Miller, Biomaterials 5, 5 (1984)

    Article  CAS  Google Scholar 

  22. D.L. Elbert, J.A. Hubbell, Chem. Biol. 5, 177 (1998)

    Article  CAS  Google Scholar 

  23. G.Q. Zhu, F.G. Wang, Q.C. Gao, Y.Y. Liu, Polym. Plast. Technol. Eng. 51, 966 (2012)

    Article  CAS  Google Scholar 

  24. G.Q. Zhu, G.C. Li, P. Wang, Polym. Plast. Technol. Eng. 50, 1470 (2011)

    Article  CAS  Google Scholar 

  25. T. Li, J.P. Lin, T. Chen, S.N. Zhang, Polymer 47, 4485 (2006)

    Article  CAS  Google Scholar 

  26. D.M. Tang, J.P. Lin, S.L. Lin, S.N. Zhang, T. Chen, X.H. Tian, Macromol. Rapid Commun. 25, 1241 (2004)

    Article  CAS  Google Scholar 

  27. A. Abe, T. Yamazaki, Macromolecules 22, 2138 (1989)

    Article  CAS  Google Scholar 

  28. L.Q. Bai, L.J. Zhu, S.J. Min, L. Liu, Y.R. Cai, J.M. Yao, Appl. Surf. Sci. 254, 2988 (2008)

    Article  CAS  Google Scholar 

  29. M.X. Zou, S.J. Wang, Z.C. Zhang, X.W. Ge, Eur. Polym. J. 41, 2602 (2005)

    Article  CAS  Google Scholar 

  30. S.D. Yoon, M.H. Park, H.S. Byun, Carbohydr. Polym. 87, 676 (2012)

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work is supported by the Natural Science Foundation of Shandong Province (No. ZR2011EMM009).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fagang Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhu, G., Wang, F., Xu, K. et al. Morphology and properties of poly(lactic acid-co-glycolic acid) film improved by blending with poly(γ-benzyl l-glutamate). Res Chem Intermed 41, 1647–1655 (2015). https://doi.org/10.1007/s11164-013-1300-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11164-013-1300-3

Keywords

Navigation