Skip to main content
SpringerLink
Log in

Synthesis and crystal structure of methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-(pyrimidin-2-ylamino)acrylate

  • Published:
Research on Chemical Intermediates Aims and scope Submit manuscript

Abstract

Methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-(pyrimidin-2-ylamino)acrylate has been prepared. Its crystal structure is discussed. The compound crystallizes in the triclinic space group P-1 with a = 11.6259 (7) Å, b = 11.8789 (7) Å, c = 13.9206 (5) Å, α = 68.0250 (10)°, β = 77.5660 (10)°, γ = 62.4950 (10)°, V = 1579.18 (14) Å3, Z = 4. There are two independent but chemically identical molecules in the asymmetric unit. The molecules are packed in the crystal structure by weak intermolecular C–H···O and C–H···F interactions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Scheme 2
Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. J.C. McPherson III, R. Runner, T.B. Buxton, J.F. Hartmann, D. Farcasiu, I. Bereczki, E. Rőth, S. Tollas, E. Ostorházi, F. Rozgonyi, P. Herczegh, Eur. J. Med. Chem. 47, 615–618 (2012)

    Article  CAS  Google Scholar 

  2. Y. Chai, J. Wang, M.L. Liu, H. Yi, L.Y. Sun, X.F. You, H.Y. Guo, Bioorg. Med. Chem. Lett. 21, 3377–3380 (2011)

    Article  CAS  Google Scholar 

  3. M.F. Saraiva, M.V.N. de Souza, M.E. Tran Huu Dau, D.P. Araújo, G.S.G. de Carvalho, M.V. de Almeida, Carbohydr. Res. 345, 761–767 (2010)

    Article  CAS  Google Scholar 

  4. X. Zhang, F. Mu, B. Robinson, P.F. Wan, Tetrahedron Lett. 51, 600–601 (2010)

    Article  Google Scholar 

  5. R. Saha, R. Nandi, B. Saha, J. Coord. Chem. 64, 1782–1806 (2011)

    Article  CAS  Google Scholar 

  6. R.A. Al-Qawasmeh, J.A. Zahra, M.A. Khanfar, Lett. Org. Chem. 6, 511–514 (2009)

    Article  CAS  Google Scholar 

  7. Y. Todo, H. Takagi, F. Iino, Y. Fukuoka, Y. Ikeda, K. Tanaka, I. Saikawa, H. Narita, Chem. Pharm. Bull. 40, 2049–2054 (1994)

    Article  Google Scholar 

  8. A.A. Boteva, O.P. Krasnykh, Chem. Heterocycl. Compd. 45, 757–785 (2009)

    Article  CAS  Google Scholar 

  9. N.B. Patel, A.L. Patel, H.I. Chauhan, Indian J. Chem. 46B, 126–134 (2007)

    CAS  Google Scholar 

  10. Y.Q. Chen, L.Y. Dai, Chin. J. Chem. Eng. 9, 310–313 (2001)

    CAS  Google Scholar 

  11. D.J. Wang, Jingxi shiyou Huagong. 6, 58–59 (1995) (in Chinese)

  12. G.M. Sheldrick, SHELXTL-97, Program for X-Ray Crystal Structure Solution (University of Göttingen, Göttingen, 1997)

    Google Scholar 

  13. G.M. Sheldrick, SADABS, Siemens Area Detector Absorption (and Other) Correction (University of Göttingen, Göttingen, 1996)

    Google Scholar 

Download references

Acknowledgments

Financial support of this work by the Natural Science Foundation of the Educational Commission of Hubei Province, P R China (no. CXY2009B029), is gratefully acknowledged.

Author information

Authors and Affiliations

  1. Hubei Key Laboratory of Pollutant and Reuse Technology, College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi, 435002, China

    Dun-Jia Wang, Lian-Ying Lu, Chun-Yang Zheng & Jing Zheng

Authors
  1. Dun-Jia Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lian-Ying Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chun-Yang Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jing Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dun-Jia Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, DJ., Lu, LY., Zheng, CY. et al. Synthesis and crystal structure of methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-(pyrimidin-2-ylamino)acrylate. Res Chem Intermed 38, 2355–2363 (2012). https://doi.org/10.1007/s11164-012-0551-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11164-012-0551-8

Keywords

Search

Navigation