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Acylation of (R,S)-1-phenylethanol with ethyl acetate over an immobilized enzyme

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Abstract

Acylation of (R,S)-1-phenylethanol, which is a product of acetophenone hydrogenation, over a Pd-supported catalyst, was studied in ethyl acetate with an immobilized lipase. It was demonstrated that in the presence of hydrogen and Pd/C in the reaction medium the (R,S)-1-phenylethanol acylation rate is not hindered, whereas the selectivity was strongly altered in the latter case, leading to significant amounts of side products.

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Acknowledgements

This work is part of the activities at the Åbo Akademi Process Chemistry Centre (ÅA-PCC) within the Finnish Centre of Excellence Programme (2000–2011) appointed by the Academy of Finland.

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Authors and Affiliations

  1. Laboratory of Industrial Chemistry and Reaction Engineering, Process Chemistry Centre, Åbo Akademi University, 20500, Turku/Åbo, Finland

    Päivi Mäki-Arvela, Serap Sahin, Kari Eränen & Dmitry Yu. Murzin

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  1. Päivi Mäki-Arvela
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  2. Serap Sahin
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  3. Kari Eränen
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  4. Dmitry Yu. Murzin
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Correspondence to Päivi Mäki-Arvela.

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Mäki-Arvela, P., Sahin, S., Eränen, K. et al. Acylation of (R,S)-1-phenylethanol with ethyl acetate over an immobilized enzyme. Res Chem Intermed 36, 245–252 (2010). https://doi.org/10.1007/s11164-010-0127-4

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  • DOI: https://doi.org/10.1007/s11164-010-0127-4

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