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Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine

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Abstract

A kinetic method for the determination of l-tyrosine (Tyr) by analyte pulse perturbation, caused by different amounts of Tyr, in the Bray–Liebhafsky (BL) oscillatory reaction realized in a continuous-flow stirred tank reactor, is proposed. For such purposes, the BL oscillating reaction was kept in a stable non-equilibrium stationary state close to the bifurcation point and was used as the matrix reaction system. Under optimum reaction conditions, the linear relationship between the kinetic parameters, ∆τ2 (the period between first two oscillations that appear after applied perturbation) as well as τend (the time elapsed between the perturbation of the BL reaction by Tyr and the termination of the oscillatory phase) and the Tyr concentrations is obtained over the ranges 1.1 × 10−6 − 9.2 × 10−6 mol L−1 and 1.1 × 10−6 − 1.4 × 10−5 mol L−1, with the limit of detections of 6.6 × 10−7 mol L−1 and 6.4 × 10−7 mol L−1. The described method that relies on a simple instrumental set-up, has been successfully applied to the determination of Tyr in a dietary supplement. Some aspects of the possible mechanism of Tyr action on the BL oscillator are discussed.

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Acknowledgements

The authors are grateful Dr. Ana Stanojević and Dr. Maja Pagnacco on initial organization of these investigations. This work was partially supported by the Ministry of Education, Science and Technological Development of Republic of Serbia (Grant Numbers NES 7743504, OI 172015 and III 45001, and Contract Numbers 451-03-9/2021-14/200146, 451-03-9/2021-14/200026 and 451-03-9/2021-14/200161).

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Authors and Affiliations

  1. University of Belgrade - Faculty of Physical Chemistry, Studentski trg 12-16, 11000, Belgrade, Serbia

    Luka Negrojević, Aleksandar Lončar, Jelena Maksimović, Slobodan Anić & Ljiljana Kolar-Anić

  2. University of Belgrade - Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia

    Slobodan Anić & Željko Čupić

  3. University of Belgrade - Faculty of Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Serbia

    Nataša Pejić

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  1. Luka Negrojević
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  2. Aleksandar Lončar
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Correspondence to Željko Čupić.

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Negrojević, L., Lončar, A., Maksimović, J. et al. Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine. Reac Kinet Mech Cat 135, 1147–1162 (2022). https://doi.org/10.1007/s11144-021-02130-5

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