The second part of this paper continues the discussion of possibilities for combining functionally different types of biomedical characterization of tissues using optical coherence tomography (OCT). In the first part, polarization-sensitive imaging and conventional approaches to elastographic mapping in OCT were considered. Here, we consider an unconventional approach to elastographic mapping based on the analysis of variability of OCT images of the deformed tissue, omitting the stage of the displacement-field reconstruction. We also discuss methods for quantification of blood flow and visualization of microvasculature, some of which have much in common with the elastographic approach based on the analysis of temporal variability of OCT frames. This similarity looks especially promising in the context of combining multiple contrast mechanisms to enable prospective multimodal OCT scanners, as is essential for biomedical progress given the complex and heterogeneous nature of real biological tissues.
Similar content being viewed by others
References
V. Yu. Zaitsev, V. M. Gelikonov, L. A. Matveev, et al., Radiophys. and Quant. Electron., 57, 52, (2014).
M. A. Sutton, W. J. Wolters, W. H. Peters, et al., Image Vision Computing, 1, 133 (1983).
T. C. Chu, W. F. Ranson, and M. A. Sutton, Experimental Mech., 25, No. 3, 232 (1985).
F. Hild and S. Roux, Strain, 42, 69 (2006).
B. Pan, K. Qian, H. Xie, et al., Measurement Sci. Technol., 20, No. 6, 062001 (2009).
B. Pan, Experimental Mech., 51, No. 7, 1223 (2011).
J. Ophir, S. Alam, B. Garra, et al., J. Med. Ultrasonics, 29, 155171 (2002).
V. Y. Zaitsev, L. A. Matveev, G. V. Gelikonov, et al., Laser Phys. Lett. 10, No. 6, 065601 (2013).
V. Y. Zaitsev, L. A. Matveev, A. L. Matveyev, et al., SPIE Proc., 8802, Optical Coherence Tomography and Coherence Techniques VI, 880208 (2013).
V. Y. Zaitsev, L. A. Matveev, A. L. Matveyev, et al., J. Biomed. Opt., 19, No. 2, 021107 (2014).
A. Amon, R. Bertoni, and J. Crassous, Phys. Rev. E, 87, No. 1, 012204 (2013).
G. Yu, T. Durduran, C. Zhou, et al., Clinical Cancer Res., 11, 3543 (2005).
H. F. Zhang, K. Maslov, M-L. Li, et al., Opt. Express, 14, 9317 (2006).
M. J. Leahy, Microcirculation Imaging, Wiley—Blackwell, New York (2012).
A. K. Dunn, R. Leitgeb, R. K. Wang, et al., Biomed. Opt. Express, 7, 1861 (2011).
F. E. Robles, C. Wilson, G. Grant, et al., Nature Photon., 5, 744 (2011).
V. X. D. Yang, M. L. Gordon, B. Qi, et al., Opt. Express, 11, 794 (2003).
B. A. Standish, A. Mariampillai, M. K. K. Leung, et al., in: V. Tuchin, ed., emphHandbook of Coherent-Domain Optical Methods, Springer, New York, (2012) p. 946.
S. Yazdanfar, A. M. Rollins, and J. A. Izatt, Opt. Lett., 25, 1448 (2000).
C. Kasai, K. Namekawa, A. Koyano, et al., IEEE Trans. Sonics Ultrasonics, 32, 458 (1985).
J. A. Jensen, Estimation of Blood Velocities Using Ultrasound: a Signal Processing Approach, Cambridge University Press, Cambridge (1996).
R. S. C. Cobbold, Foundations of Biomedical Ultrasound, Oxford University Press, Oxford (2007).
R. Leitgeb, L. Schmetterer, W. Drexler, et al., Opt. Express, 11, 3116 (2003).
R. K. Wang and L. An, Opt. Express, 17, 8926 (2009).
V. J. Srinivasan, S. Sakaszic, I. Gorczynska, et al., Opt. Express, 18, 2477 (2010).
H. Ren, Y. Wang, J. S. Nelson, et al., SPIE Proc., 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, 225 (2003).
K. Kurokawa, K. Sasaki, S. Makita, et al., Opt. Express, 20, 22796 (2012).
R. K. Wang, S. L. Jacques, Z. Ma, et al., Opt. Express, 15, 4083 (2007).
L. An and R. K. Wang, Opt. Express, 16, 11438 (2008).
G. van Soest, T. Goderie, E. Regar, et al., J. Biomed. Opt., 15, 011105 (2010).
S. Yousefi, J. Qin, and R. K. Wang, Biomed. Opt. Express, 4, 1214 (2013).
R. K. Wang, Opt. Lett., 33, 1878 (2008).
J. Fingler, D. Schwartz, C. Yang, et al., Opt. Express, 15, 12636 (2007).
A. Mariampillai, B. A Standish, E. H. Moriyama, et al., Opt. Lett., 33, 1530 (2008).
A. Mariampillai, M. K. K. Leung, M. Jarvi, et al., Opt. Lett., 35, 1257 (2010).
B. J. Vakoc, R. M. Lanning, J. A. Tyrell, et al., Nature Medicine 15, 1219 (2009).
J. K. Barton and S. Stromski, Opt. Express, 13, 5234 (2005).
J. W. Goodman, Statistical Optics, Wiley, New York (2000).
L. Conroy, R. DaCosta, and I. A. Vitkin, Opt. Lett., 37, 3180 (2012).
B. Davoudi, M. Morrison, K. Bizheva, et al., J. Biomed. Opt., 18, 076008 (2013).
J. Fingler, R. J. Zawadzki, J. S. Werner, et al., Opt. Express, 17, 22190 (2009).
A. Mariampillai, Development of a High Resolution Microvascular Imaging Toolkit for Optical Coherence Tomography, PhD thesis in med. biophys, University of Toronto, Toronto (2010).
S. M. Mahmut, D. W. Cadotte, B. Vuong, et al., J. Biomed. Opt., 18, 050901 (2013).
E. Jonathan, J. Enfield, M. J. Leahy, J. Biophoton., 4, 583 (2010).
N. Mohan and B. J. Vakoc, Opt. Lett., 36, 2068 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Radiofizika, Vol. 57, No. 3, pp. 231–250, March 2014.
Rights and permissions
About this article
Cite this article
Zaitsev, V.Y., Vitkin, I.A., Matveev, L.A. et al. Recent Trends in Multimodal Optical Coherence Tomography. II. The Correlation-Stability Approach in OCT Elastography and Methods for Visualization of Microcirculation. Radiophys Quantum El 57, 210–225 (2014). https://doi.org/10.1007/s11141-014-9505-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11141-014-9505-x