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Antioxidant and Renin Inhibitory Activities of Peptides from Food Proteins on Hypertension: A Review

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Abstract

Hypertension is a condition induced by oxidative stress causing an alteration in the endothelium, which increases the risk of suffering from other degenerative diseases. This review compiles the findings on peptides from food proteins with antioxidant and antihypertensive activities. Antihypertensive peptides are mainly focused on renin inhibition. Peptides containing hydrophobic amino acids have antioxidant and renin inhibitory activities, as reported by studies on the biological activity of peptides from various food sources evaluated separately and simultaneously. Peptides from food sources can present multiple biological activities. Moreover, antioxidant peptides have the potential to be evaluated against renin, offering an alternative for hypertension therapy without causing adverse side effects.

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Data is available in public repositories that issue datasets with DOIs (provided in references).

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Acknowledgements

The authors thank the Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional (ENCB-IPN) for the support and the Consejo Nacional de Ciencia y Tecnología (CONACYT) for the grant provided.

Funding

This study was funded by Secretaria de Investigacion y Posgrado (Project SIP20230172), of the Instituto Politecnico Nacional. México.

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Authors and Affiliations

  1. Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, CDMX, Av. Wilfrido Massieu Esq. Cda. Miguel Stampa S/N, Delegación Gustavo A. Madero, C.P. 07738, Coahuila, México

    Deyanira del Rosario Moguel-Concha, José Eduardo Borges-Martínez, Ana Luisa Gómez-Gómez, Darío Iker Téllez-Medina & Cristian Jiménez-Martínez

  2. Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Delegación Gustavo A. Madero, CDMX, Av. Acueducto. La Laguna Ticomán, C.P. 07340, Coahuila, México

    María Stephanie Cid-Gallegos

  3. Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Calzada de la Revolución Mexicana S/N, La Fe. C.P. 98615, Guadalupe, Zacatecas, México

    Milagros Faridy Juárez-Chairez

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  1. Deyanira del Rosario Moguel-Concha
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Contributions

Deyanira del Rosario Moguel-Concha: Conceptualization, Writing – Original Draft, Editing. José Eduardo Borges-Martínez: Writing – Original Draft, Review. María Stephanie Cid-Gallegos: Conceptualization, Writing – Original Draft. Milagros Faridy Juárez-Chairez: Review and Editing. Ana Luisa Gómez-Gómez: Editing. Darío Iker Tellez-Medina: Supervision, Review and Editing. Cristian Jiménez-Martínez: Supervision, Review and Editing.

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Correspondence to Cristian Jiménez-Martínez.

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Moguel-Concha, D.d., Borges-Martínez, J.E., Cid-Gallegos, M.S. et al. Antioxidant and Renin Inhibitory Activities of Peptides from Food Proteins on Hypertension: A Review. Plant Foods Hum Nutr 78, 493–505 (2023). https://doi.org/10.1007/s11130-023-01085-3

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