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Renal Protective Effects of Extracts from Guava Fruit (Psidium guajava L.) in Diabetic Mice

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An Erratum to this article was published on 07 September 2012

Abstract

This study analyzed the content of phenolic acids and flavonoids in extracts of guava fruit (Psidium guajava L.), and examined the renal protective effects of guava aqueous extract (GAE) and ethanol extract (GEE) in diabetic mice. GAE had more caffeic acid, myricetin, and quercetin; and GEE had more cinnamic, coumaric and ferulic acids. GAE or GEE at 1 and 2 % was supplied in diet for 12 weeks. GAE or GEE intake at 2 % significantly reduced glucose and blood urea nitrogen levels, increased insulin level in plasma of diabetic mice (p < 0.05). GAE or GEE treatments dose-dependently reserved glutathione content, retained activity of catalase and glutathione peroxidase, and decreased reactive oxygen species, interleukin (IL)-6, tumor necrosis factor-α and IL-1β levels in kidney (p < 0.05). GAE and GEE treatments at 2 % significantly declined renal N ε-(carboxymethyl)lysine, pentosidine and fructose levels (p < 0.05), and suppressed renal activity of aldose reductase (p < 0.05). These findings support that guava fruit could protect kidney against diabetic progression via its anti-oxidative, anti-inflammatory and anti-glycative effects.

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Abbreviations

AGE:

Advanced glycation endproduct

AR:

Aldose reductase

CML:

N ε-(carboxymethyl)lysine

Cr:

Creatinine

IL-6:

Interleukin-6

GPX:

Glutathione peroxidase

GSSG:

Oxidized glutathione

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

TNF-α:

Tumor necrosis factor-α

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Acknowledgments

This study was supported by a grant from China Medical University, Taichung City, Taiwan (CMU100-ASIA-01).

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Health and Nutrition Biotechnology, Asia University, Taichung City, Taiwan

    Chia-Yun Lin & Mei-Chin Yin

  2. Department of Nutrition, China Medical University, 91, Hsueh-shih Rd., Taichung City, Taiwan

    Mei-Chin Yin

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  1. Chia-Yun Lin
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  2. Mei-Chin Yin
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Correspondence to Mei-Chin Yin.

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Lin, CY., Yin, MC. Renal Protective Effects of Extracts from Guava Fruit (Psidium guajava L.) in Diabetic Mice. Plant Foods Hum Nutr 67, 303–308 (2012). https://doi.org/10.1007/s11130-012-0294-0

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