Abstract
Peak sales are an important metric in the pharmaceutical industry. Specifically, managers are focused on the heightofpeaksales and the time required achieving peak sales. We analyze how order of entry and quality affect the level of peak sales and the timetopeaksales of pharmaceutical brands. We develop a growth model that includes these two variables as well as control variables for own and competitive marketing activities. We find that early entrants achieve peak sales later, and they have higher peaksales levels. Highquality brands achieve peak sales earlier, and their peaksales levels are higher. In addition, quality has a moderating effect on the order of entry effect on timetopeaksales. Our results indicate that late entrants have longer expected timetopeaksales when they introduce a brand with high quality.
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1 Introduction
New products play a very important role in the pharmaceutical industry (Leenders and Wierenga 2008; Stremersch and van Dyck 2009). Pharmaceutical firms constantly introduce new drugs, and for these new drugs, peak sales represent an important metric, frequently used by investors to assess pharmaceutical firms’ value (Obeid and Vine 2005; Suresh et al. 2006).
Peak sales can be characterized along two dimensions: the heightofpeaksales and the timetopeaksales. Both metrics are closely related to new product performance such as cumulative sales. Intuitively, a brand with a higher level of peak sales is likely to have higher average sales over its life cycle. As a result, cumulative sales are also higher. Similarly, a brand with longer timetopeaksales enjoys a longer period of growth that contributes to accumulate sales and achieve a higher level of peak sales. Consequently, cumulative sales are again higher.
There are, however, exceptions to these rules. For example, a high level of peak sales may be achieved very fast. Although, we cannot rule out such a case theoretically, we do not believe it occurs often in reality because of restrictions to growth. Note that the growth rate needs to double if the same level of peak sales is to be achieved in half of the time. Firms can handle faster growth only up to a certain level due to supply and resource restrictions. In Appendix A, we also demonstrate that faster growth implies a higher variance of sales and therefore higher cashflow volatility which is not desirable (Srivastava et al. 1998). Hence, even if demand might allow for a shorter timetopeak sales, there are limits to growth from the supply side. The broad sample of new drugs that forms the basis of our empirical study supports our view. Timetopeaksales enhances heightofpeak sales and both peaksales metrics increase cumulative brand sales. Together the two metrics explain more than 96% of observed variance in cumulative brand sales.
Timetopeaksales and heightofpeaksales provide two important yardsticks that are easy to evaluate and predict even before launch. Assume management wants to assess the sales potential of a new product two years prior to launch. Cumulative sales may be obtained from the life cycle curve. Predicting the lifetime and sales for all periods, however, requires much more information than predicting only two peaksales metrics. It is much easier to reach a consensus estimate for timetopeaksales and heightofpeaksales. For pharmaceuticals, as an example, management can triangle information on the population size, the incidence of a disease and the reachable market share for the new drug to obtain an estimate for the heightofpeaksales. Management would certainly use information on competitive entries, order of entry, marketing investment, etc. to predict the peaksales metrics. Our empirical analysis provides important insights into the relevance of these variables for peak sales. Importantly, the analysis also suggests that those variables do not provide explanatory power for cumulative sales beyond the two peaksales metrics. Hence, peaksales metrics cannot simply be substituted by other predictors.
It is therefore not surprising that peaksales metrics are widely adopted in practice, especially within the pharmaceutical industry. For example, Salix Pharmaceuticals reportedly has tumbled because its IBD franchise will “only achieve peak sales of $ 99 million, lower than its previous estimate of $ 135 million because of the Dec. 28 approval of three generic balsalazide (Colazal) formulations by the Food and Drug Administration” (Trading Markets.Com 2007). The importance of peaksales metrics prompts business intelligence agencies such as IMS or Datamonitor to predict the peak sales of newly introduced drugs (e.g., Datamonitor 2007). Not only are the metrics important in practice (Obeid and Vine 2005), but scholars also acknowledge their relevance. For example, Bauer and Fischer (2000) and Schmid and Smith (2002) demonstrate that timeto and heightofpeaksales differ across brands introduced into different drug categories and countries due to factors such as order of entry.
In the marketing literature, there has been extensive attention to the role of order of entry and quality with regard to (new product) performance (Gielens and Dekimpe 2001; Kalyanaram and Urban 1992; Kalyanaraman and Wittink 1994; Robinson and Fornell 1985; Shankar et al. 1998). An important debate addresses the question whether first movers really have a competitive advantage as is often attributed to them (Golder and Tellis 1993; Kornelis et al. 2008; Zhang and Narasimhan 2000). Quite in contrast, recently Tellis and Johnson (2007) argue that delivering superior quality is considered as the most important driver of new product success. Hence, we assess the role of order of entry and quality for the market performance of a new drug in terms of peak sales.
The main objective of this study is to determine the drivers of heightof peaksales and timetopeaksales in the pharmaceutical industry. Through this study we contribute to the literature on new products and brand life cycles (Hauser et al. 2006), as this is the first study to investigate drivers of timeto and heightofpeaksales. We show that some drivers differentially impact heightofpeaksales and timetopeaksales. For example, marketing expenditures increase the level of peak sales, while they decrease the timetopeaksales. We aim to contribute to the literature on drivers of new product performance with a further investigation on the relative roles of order of entry, quality, and marketing efforts (see Tellis and Johnson 2007). Importantly, our results suggest that quality has by far the strongest positive effect on heightofpeaksales, while it reduces the timetopeaksales. Finally, by executing this study in the pharmaceutical industry we also contribute to existing knowledge on pharmaceutical marketing (e.g. Kremer et al. 2008; Stremersch and van Dyck 2009).
The article is organized as follows: In the next section, we review the literature on drug life cycles and provide explanations why peak sales is a quite common phenomenon in the evolution of drug sales. Subsequently, we discuss potential drivers of timeto and heightofpeaksales and how they might affect the two metrics. We develop a model to measure the effects, then describe data from the pharmaceutical industry and discuss estimation issues. We follow up with a discussion of the empirical results. We continue with a crosssectional analysis of new product performance to substantiate the relevance of the suggested metrics. In the final section, we conclude with research implications, limitations, and suggestions for further research.
2 Drug life cycles and peak sales
2.1 Life cycle research
Studying the length and the shape of brand life cycles has a long history, including studies by Bauer and Fischer (2000), Brockhoff (1967), and Polli and Cook (1969). Research on specific metrics at the brand level in the development of the brand life cycle is scarce. Heightofpeaksales and timetopeaksales have not been studied so far. Remarkably, studying the diffusion of article citations in Econometrica and the Journal of Econometrics, Fok and Franses (2007) model the timetopeak citations and peakcitations of an article. Hence, though studied in a different context, there is academic attention for peak metrics in the econometric diffusion literature. We believe it is important to study such metrics in a new product context as well, as we will show that both these metrics are highly relevant for practice and they both are the most important determinants of cumulative brand sales.
Research at the product level has, however, investigated other specific metrics, as overviewed in Table 1. Several studies consider timetotakeoff and subsequent growth of consumer durables (i.e., VCRs, televisions), as well as their drivers (Agarwal and Bayus 2002; Neelameghan and Chintagunta 2004; Golder and Tellis 1997; Stremersch and Tellis 2004; Tellis et al. 2003). Bayus (1998) specifically analyzes product lifetime as an important metric. Although these studies provide insights into which factors (i.e., economic, cultural) influence timetotakeoff at the product level by country, they do not clarify the drivers at the brand level.
2.2 Brand life cycles in drugs
The development of demand for a new drug derives from both adoptions and repeats. For many drugs, the evolution of sales shows a peak. In Fig. 1, we depict the sales development of different brands in the French calcium channel blockers market. On the Xaxis, we display the launch years of new drugs, and on the Yaxis, we provide annual sales for three entrants in this market. The figure clearly shows the occurrence of sales peaks. For example, the second entrant reaches its peak in 1988 with a sales level of approximately 200 million daily dosages.
The theories of adoption and imitation (Bass 1969) and informational cascades (Golder and Tellis 2004) explain why brand sales follows a life cycle. However, they are usually associated with the product level and firsttime adoptions. Brand sales are, in addition, composed of repeat purchases, and they are subject to competition (Hahn et al. 1994).
Although some authors have questioned the transfer of the product life cycle concept to brands (Dhalla and Yuspeh 1976), brand life cycles have been reported quite frequently. The broadest evidence for brand life cycles is available for pharmaceuticals. Bauer and Fischer (2000), Corstjens et al. (2005), Cox (1967), Grabowski and Vernon (1990), Hahn et al. (1994), Lilien et al. (1981), Rao and Masataka (1988), and Simon (1979) all find strong evidence for the existence of a drug life cycle. In total, these researchers document the life cycles for more than 500 newly introduced drugs.
There are potentially several reasons why especially pharmaceuticals exhibit a peak in their sales trajectory. First, diffusion dynamics seem to be dominant for the evolution of (prescription) drug sales. Although refills have a large share in total drug sales, sales dynamics are predominantly driven by firsttime prescriptions. This is simply due to the fact that physicians are reluctant to change a drug (i.e. the firsttime prescription) once it has been found to work for a patient, even in response to heavy marketing initiatives by competitor brands. As a result, researchers have adopted diffusion approaches to model drug sales with repeats where repeat rates are assumed constant (e.g., Hahn et al. 1994; Shankar et al. 1998). Second, pharmaceutical companies concentrate the bulk of their marketing efforts (i.e., detailing) on the first two years after launch, which causes an immediate strong increase in prescriptions but results in slower sales growth or even decline in later years when marketing support is only limited (Osinga et al. 2010). Third, by definition there is a limit in users of a drug as it is only relevant for patients with a specific treatment for a disease. Fourth, the entry of new competitors may inhibit sales growth to continue. These competitors may be other innovative drugs within the same or new categories, or generics after the patent has expired.
One might argue that instead of studying timeto and heightofpeaksales, one should study the timetotakeoff metric (e.g. Tellis et al. 2003). As noted, this metric has been studied at the category level but not at the brand level. So far, there is no empirical evidence in the literature that this phenomenon occurs at the brand level, as well. We explored the available brand timeseries but did not find evidence for a salestakeoff phenomenon. Hence, beyond our substantive arguments there are also empirical arguments to study peaksales metrics.
3 Variables affecting peak sales of pharmaceutical brands
3.1 Potential peaksales drivers
In this study, we focus on the impact of order of entry and quality on (1) the timetopeaksales and (2) the heightofpeaksales. We control for the effect of other, potentially relevant variables. Specifically, we consider own and competitive marketing support, the number of competitive entries into the market, the price of the drug, and marketing expenditures by comarketing partners as control variables in the proposed brand sales model.
We define a pharmaceutical brand as a new chemical entity (NCE) marketed by a company in a specific country. Typically, innovative drugs enjoy patent protection for several years after launch. The competitive situation changes dramatically for an innovative drug when its patent expires and cheaper generic competitors rush into the market. In addition, innovative brands may be attacked by brands from other categories that offer alternative forms of drug treatment (technological substitution). Given that our data come from two categories that belong to the most innovative categories without generic price competition in our observation period, we focus on effects from competition among innovative prescription drugs within a category.
The sales evolution, and thus our focal metrics timetopeaksales and heightofpeaksales, is determined by four key metrics: the speed of adoption, the size of the adopter (patient) potential, the repurchase (refill) rate and the interpurchase time. For the majority of categories, repeat sales dynamics (interpurchase time and repurchase/refill rate) are determined by exogenous factors such as therapy guidelines, patient characteristics, and physician skills. Physicians rarely risk switching the patient to another drug in response to marketing activities, because effectiveness and compatibility of the new drug are uncertain to a patient. Additionally, the time between refills follows medical needs for optimal treatment. As a consequence, we focus on the diffusion metrics speed of adoption and size of adopter potential in our discussion of orderofentry and quality effects on peak sales as these decision variables do not change the repeat sales dynamics. Aggregate repeat sales metrics are constant over the life cycle of a drug unless therapy guidelines are replaced or the distributions of patient and physician characteristics change systematically (Hahn et al. 1994).
3.2 Effects of order of entry and quality
3.2.1 Order of entry
Multiple studies investigate the impact of order of entry on a brand’s market share and sales (e.g., Kalyanaram et al. 1995; Robinson and Fornell 1985; Urban et al. 1986). Late entrants grow faster but achieve lower market share levels (Kalyanaram and Urban 1992). The effect has also been demonstrated for pharmaceuticals (Berndt et al. 1995; Shankar et al. 1998). These results are due to the fact that latemover drugs face a lower adopter potential that is faster penetrated. In addition, late entrants are less effective than early entrants in competing for the remaining potential adopters (Kalyanaram and Urban 1992; Lieberman and Montgomery 1988). As a result, late entrants expect a lower level of peak sales and a shorter timetopeaksales. We note, however, that this effect may be moderated by other variables such as quality.
If late entrants penetrate the expected lower adopter potential at the same speed with similar support and quality as earlier entrants, timetopeaksales will be shorter. There are, however, good reasons to believe that their adoption speed is even faster than for early entrants. This is because buying resistance at the category level is much lower than it had been in earlier periods of the market life cycle. With more brands, consumers have had multiple opportunities to collect consumption experiences. Furthermore, social pressures on later adopters may favor trial probabilities for late mover brands (Bass 1969; Rogers 1995). The entry of another brand should not only increase brand variety but also enhance marketing activity in terms of pricing, advertising and promotion, which may lead to faster adoptions (Horsky and Simon 1983; Krishnan et al. 2000; Prins and Verhoef 2007). To summarize, we expect order of entry to reduce both the timetopeaksales and the heightofpeaksales.
3.2.2 Quality
Quality is considered of essential importance for new product success (Tellis and Johnson 2007). There is no doubt that a better quality increases the attractiveness of the brand, which in turn should enlarge its adopter potential. Indeed, many studies demonstrate the positive sales effect of quality for drugs (Berndt et al. 1995). Hence, we expect a positive relation between the level of quality and the level of peak sales.
Adoption theory predicts that adoption will be faster for products with a relative quality advantage (Rogers 1995). Consequently, highquality brands should face lower adoption barriers leading to a shorter timetopeaksales. The expected timetopeaksales should therefore decrease with quality. However, we have also argued that a better quality enlarges the adopter potential leading to a potentially longer timetopeaksales. If this effect is stronger than the accelerated adoption (trial) effect, we would expect a longer timetopeaksales for highquality brands. As a consequence, we cannot provide a clear prediction about the direction of the (direct) quality effect and consider it as an empirical issue.
3.2.3 Interaction between order of entry and quality
Prior research has shown that the innovativeness of a new drug can reduce the disadvantage from being a late entrant (Shankar et al. 1998). The study of Shankar et al., however, focused on market share or brand sales, but not on peaksales metrics. Hence, we cannot make any inference about the interaction effect between quality and orderofentry with respect to the timetopeaksales. For timetopeaksales, we expect that a higher quality reduces the negative effect of a late entry on the timetopeaksales. A product with better quality may provide the late entrant with more opportunities to gain prescriptions from competing incumbent brands. Lowquality late entrants won’t be able to attract these prescriptions. As a consequence, the adopter potential for lowquality entrants will be lower and they achieve their peaksales earlier than highquality late entrants. Quality thus reduces the negative impact of order of entry on timetopeaksales, i.e. we expect a positive interaction effect between quality and order of entry.
3.3 Control variables
3.3.1 Own marketing support
The amount of marketing support will affect the timeto and heightofpeaksales. Prior research shows that higher marketing expenditures speed up adoption (Gielens and Steenkamp 2007; Prins and Verhoef 2007; Steenkamp and Gielens 2003). Diffusion research demonstrates that higher marketing expenditures increase the diffusion rate and extend the market potential of adopters (Horsky and Simon 1983; Mahajan et al. 1990). Depending on which of these two effects is larger, the timetopeaksales will be shortened or extended. A recent metaanalysis (Kremer et al. 2008) shows that own marketing expenditures improve the sales base of a drug. Hence, we expect a positive effect of own marketing support on the heightofpeaksales.
3.3.2 Competitive marketing support
Initially, we might predict that competitive marketing expenditures negatively affect the timetopeaksales. Prins and Verhoef (2007) show that competitive advertising reduces time to adoption. But competitive marketing efforts may also have a categorybuilding effect that enhances both own and competitors’ brand sales (Dubé and Manchanda 2005; Fischer and Albers 2010) and may extend the timetopeaksales. As a consequence, it is difficult to provide a clear prediction about the effect of competitive marketing expenditures on timetopeaksales.
3.3.3 Number of competitors
The number of competitors in the market might also be relevant in explaining both timeto and heightofpeaksales. The market share theorem (Cooper and Nakanishi 1988) postulates that a brand’s market share is inversely related to the number of competitors in a market. The brand looses in relative attractiveness. The loss in attractiveness may have different sources. The memorysequence effect (Alpert and Kamins 1994) or the variety seeking phenomenon (McAlister and Pessemier 1982) may explain the loss in attractiveness when more competitors are present in a market. We expect that the number of competitors reduces both the timetopeaksales and the heightofpeaksales.
3.3.4 Price
In the empirical application, we use a sample of firms and brands from four European countries (France, Germany, Italy, and the U.K.) during the period 1987–1996. The systems of health insurance and price regulation in these countries explain why pharmaceutical firms did not use price as a tactical marketing instrument in that period. In France and Italy, prices are determined exogenously by the respective authorities. In principle, launch prices can be set freely in the U.K. and Germany. Because drug expenses are typically reimbursed, demand is inelastic. As a result, firms have no incentive to reduce the price over time. Since a subsequent increase of the approved launch price would result in the loss of the reimbursement status, prices are also not raised in later periods and thus stay rather constant. Hence, price plays more or less the role of a crosssectional control variable in this specific sample. Note also that we do not observe generic price competition in the sample.
3.4 Summary
We provide a summary of the expected effects of our included drivers of timeto and heightofpeaksales in Table 2. In this table, we also report the operationalization of these variables, which we discuss in the next section in more detail. Finally, we note that we do not include distribution as predictor in our model (Kremer et al. 2008; Manchanda et al. 2005), as drug distribution in Europe is highly regulated, such that pharmacies are required by law to supply all approved prescription drugs.
4 Data
4.1 Data sources
We test our propositions using data from two prescription drug categories, calcium channel blockers and ACE inhibitors. These categories differ in their therapeutic principles for treating diseases such as hypertension or coronary heart disease. Data collected by IMS Health are available on a quarterly basis for a time period of 10 years (1987–1996) in each country. During that period, calcium channel blockers and ACE inhibitors represented the two largest (in monetary value) categories of cardiovascular therapy. They offered the most advanced therapy alternatives for the treatment of hypertension, as an example, and substituted sales from established older categories such as diuretics or beta blockers. Lipid modifying agents (e.g., Lipitor) and AIIinhibitors (e.g., Cozaar), which lead today’s cardiovascular drug prescriptions, were only available at the very end of the observation period.
The data include normalized (across different application forms) unit sales (transformed into daily dosages by a brandspecific dosage factor), daily dosage price and marketing spending, including expenditures on detailing (>90% of total spending), professional journal advertising and direct mailings. Sampling expenditures and other belowtheline activities (e.g., dinner invitations for physicians) are not covered. The data come from four European countries—France, Germany, Italy, and the United Kingdom—and comprise 73 brands in eight product markets (2 categories × 4 countries). In addition, the data provide the month of product launch, a quality measure for each NCE and marketing expenditures by competitors and firms comarketing the product, a frequently used method in this industry to enhance the diffusion of a new drug among physicians.
Both categories experienced multiple brand entries during the study period. The first calcium channel blocker was introduced in Germany in 1963 by Knoll, a German company which has been acquired by Abbott. The first ACE inhibitor was introduced in the United States and other countries in 1981 by Bristol MyersSquibb. Additional countries followed quickly in both categories. Between 9 and 12 brands entered the country markets in each category, with most entries occurring during our observation period. Both categories experienced considerable growth in the 1980s, which slowed down or even turned into negative growth by 1996. The categories are comparable in their sales histories.
Even though the patent expired for a few early entrants in the calcium channel blocker category in the 1980s, intense generic competition did not evolve during our observed period. This is mainly due to the fact that cost containment issues did not play an important role in prescription behavior at that time. The market share of the few generic competitors is on average below 1%. In addition, we observe that all innovative brands continued to grow after they lost patent protection, i.e. patent expiry does not coincide with timetopeaksales.
4.2 Measurement and descriptive statistics
We adopt the slowdown measure by Golder and Tellis (2004) to determine each brand’s time of peak sales and crossvalidate this decision through visual inspections of the time series. 45 brands out of 73 brands reach their peak sales during the 10year observation period. A few brand time series are lefttruncated because they were launched before the start of the observation period. Thus, we have an unbalanced panel data set with 31 quarters per brand, on average, which we use to calibrate our model.
Our dataset shares a limitation with most previous studies on growth models. The data series are censored to the right. Hence, in a very strict sense, we cannot be absolutely sure that we observe the peak. It may just be a saddle phenomenon (Goldenberg et al. 2002), although that has not been documented for pharmaceutical brand sales so far. We therefore analyze the distribution of peak sales years and timestopeak sales. We find that more than 60% of peak sales occurred three years before the end of the observation period or earlier. The distribution of peaksales years follows a normal distribution (p > .05). Additionally, we find that for 80% of the brands timetopeaksales amounts to four years or longer. Hence, we have much confidence that our data are representative of the peak sales phenomenon in the analyzed categories. We also test the robustness of the results later when we change the composition of the sample to eliminate left truncation issues, as an example.
In Table 3, we summarize information about the timeto and heightofpeaksales for the 45 brands. The average timetopeaksales for calcium channel blockers is higher because of the very early introduction of the pioneer in all countries that we investigate. In several cases, early entrants continue to grow after later entrants already have achieved their peak. We also note that the time of the category sales peak does not necessarily coincide with the time when brand sales peak. Hence, the timetopeak in terms of category demand appears to be independent of the timetopeak in brand demand.
We provide means and standard deviations of other key variables for the 45 brands in Table 3. The heightofpeaksales is slightly more than four times greater than the average brand sales in both categories.
Timetopeaksales and heightofpeaksales are correlated with .424. As expected, the association is positive, i.e. a longer timetopeaksales helps accumulating sales and achieving a higher level of peak sales. We also correlate our two focal measures with the cumulative (unit) sales and approximated cumulative discounted cash flows (DCF). The correlations of heightofpeaksales with cumulative sales and discounted cash flows are .981 and .935, respectively. Correlations are smaller but still sizeable with respect to timetopeaksales: .470 (cumulative sales) and .336 (cumulative DCF). In Section 7 we will further elaborate on the relationships of the peaksales metrics with cumulative sales and cumulative DCF.
The operationalization of the quality index deserves special attention. We adopt an objective quality index based on international medical evaluation standards (for a similar approach, see Venkataraman and Stremersch 2007). This index measures the objective quality of each NCE along seven equally weighted dimensions that capture the breadth of application, efficacy, convenience, and pharmacokinetic performance of the drug. Specifically, the dimensions are the number of approved indications, number of interactions, frequency of side effects, frequency of medication, protein absorption, plasma halflifetime, and bioavailability (for details see Appendix B including Table 8).
5 Econometric model and estimation
5.1 Brandgrowth model
Bertalanffy (1957) proposes a generalized mathematical theory of growth that encompasses many longterm growth models discussed in the marketing literature. The idea behind that theory is that growth processes can be formalized by a general differential equation that represents the antagonism of progress and decay. Diffusion models such as the Bass (1969) model derive from that theory and have found wide application in marketing. Several limitations of the Bass model, however, prevent its use for our data. The model focuses on the category level and explains firsttime adoptions of a new product (Mahajan et al. 1990). We need to model sales at the brand level that is composed of both adoptions and repeat purchases. We note that there are a few extensions of the Bass model that apply to brand diffusion and incorporate repeat purchases (e.g., Hahn et al. 1994; Krishnan et al. 2000). These models, however, require accounting for competitor diffusion and repeat dynamics that increase model complexity, especially if many brands are to be analyzed as in our study. In addition, the Bass model assumes a growth process that is for the most part symmetric around the time of peak sales.^{Footnote 1} Previous research suggests that drug sales follow an asymmetric life cycle (e.g., Bauer and Fischer 2000). A parametric growth model that derives from Bertalanffy’s general theory but is not subject to these limitations is Brockhoff’s (1967) model. It assumes an asymmetric growth path that leads to a single peak in a brand’s lifetime. Consistent with this growth model, we specify sales of brand i in (calendar) period t as follows^{Footnote 2}:
where
 s _{ it } :

Sales of brand i in period t
 m _{ i } :

Brandspecific scaling constant
 LCT _{ it } :

Elapsed time since market introduction of brand i in (calendar) period t
 a _{ i } ,b _{ i } :

Brandspecific growth parameters and
 g[Z_{ it }]:

A multiplier shifting sales depending on the Zvector of relevant predictors of brand i in period t.
This model has several desirable properties. For example, if we differentiate Eq. 1 with respect to LCT and set the expression equal to 0, we obtain an expression for the timetopeaksales, \( {\psi_i} = \frac{{{a_i}}}{{{b_i}}} \), and thus
5.2 Brand sales model
Following Ainslie et al. (2005), we insert Eq. 2 into (1). We introduce k for category, l for country, specify the variables in Z explicitly, and take the logarithm of sales to derive an equation that is linear in response parameters. We then arrive at:
where:
 OE _{ kli } :

Order of entry of brand i in category k and country l
 Q _{ kli } :

Quality of brand i relative to the average in category k and country l
 PRC _{ klit } :

Price of brand i in category k, country l, and period t
 MES _{ klit } :

Stock of own marketing expenditures of brand i in category k, country l, and period t
 ComMES _{ klit } :

Stock of marketing expenditures by brand i′s competitors (excluding comarketing partners) in category k, country l, and period t
 CoMES _{ klit } :

Stock of marketing expenditures by pharmaceutical companies that comarket brand i in category k, country l, and period t
 SD _{ hlt } :

Seasonal dummy variable for quarter h in country l and period t
 m,Ψ,b,β,γ,δ:

(Unobserved) parameter vectors
 v,τ,ω, u,σ²:

Error terms and error variances
 k :

1, K=2 (number of categories)
 l :

1, 2, .., L=4 (number of countries)
 i :

1, 2, …, I _{ kl } (number of brands per category and country)
 t :

1, 2, …, T _{ i } (number of observation periods per brand); and
 h :

1, 2, ., H=4 (number of quarters).
Recall that a product market is defined as category by country. The terms η_{ kli }, υ_{ kli }, μ_{ kli }, and λ_{ kli } denote brandspecific deviations of heterogeneous parameters from their mean \( (\bar{m},\bar{b},\bar{\psi },\,{\hbox{and}}\,\bar{\gamma }) \) across product markets and brands, assumed to be drawn from a normal distribution with 0 mean and constant variance. In this way, we account for heterogeneous effects that facilitate the pooling of the crosssectional and timeseries data. We do not model β _{ 1 } and β _{ 2 } as heterogeneous because these parameters are associated with timeindependent variables. Although in theory, it is possible to identify heterogeneous parameters from purely crosssectional information, it remains a challenging task in real data sets (Bodapati and Gupta 2004). This logic also applies to β _{3}, the parameter associated with price. Although price is fundamentally a timevarying quantity, we observe almost no time variation in our data supporting our view that it was not used as a marketing instrument by firms. Here, we treat price as a crosssectional control variable. The model also includes a brandspecific scaling constant (m _{ kli }) that controls for unobserved brandspecific effects, such as brand equity, that are assumed to be randomly distributed across brands.
We follow Berndt et al.’s (1995) approach for measuring the stock of pharmaceutical marketing expenditures, and find a quarterly carryover coefficient of .540 (see Table 2 for more details). We test whether the carryover coefficient differs for the two product categories but find no significant differences. By including marketing stock variables, we account for sales dynamics that are typical for new drugs due to inertia and diffusion effects. The stock of competitive marketing expenditures reflects the impact of competitors’ marketing campaigns on own brand sales. We include the stock of comarketing expenditures to account for the impact of comarketing deals between pharmaceutical firms. The brand sales model accommodates possible seasonal fluctuations in drug demand by country according to quarterly dummy variables.
Finally, the model shows a nested, multilevel error structure which consists of error components that are categoryspecific, ν_{ k }, countryspecific, τ_{ l }, and productmarketspecific, ω_{ kl }. We assume these errors and the idiosyncratic error, u _{ klit }, to be uncorrelated. As a result, the error variance is \( {\hbox{Var}}\left( {{\nu_k} + {\tau_l} + {\omega_{kl}} + {u_{klit}}} \right) = \sigma_\nu^2 + \sigma_\tau^2 + \sigma_\omega^2 + \sigma_u^2 \). With this error structure, we account for differences in market size between categories, countries, and product markets. In addition, this specification implies that errors are contemporaneously correlated across categories within a country, across countries within a category, and across brands within a product market.
5.3 Timetopeaksales model
The brand sales model (Eq. 3) includes the timetopeaksales, Ψ _{ kli }, as an unobserved heterogeneous parameter that can be decomposed into a mean and a random component. We extend this specification and allow the mean to be shifted by the following crosssectional variables:
where \( t_i^{PEAK} \) denotes the calendar year in which a brand achieved its peak sales, NC denotes the number of competitors in a product market, ζ is an i.i.d. error term uncorrelated with the error terms of Eq. 3, and all other terms are defined as previously. We take the log of the number of competitors, and of own and competitive marketing stock to account for diminishing returns, measured at the time the brand reaches its peak sales. Order of entry and quality, which are timeinvariant, get measured at the time of launch. Note that \( t_i^{PEAK} \) measures calendar time that is unrelated to Ψ _{ kli }, a duration variable (correlation coefficient = −.171, p > .10). Hence, there are no endogeneity concerns arising from time of measurement.
5.4 Estimation
Equations 3 and 4 establish a multilevel regression model. We estimate the model using the simulated maximum likelihood technique that was also used by Fok and Franses (2007). Under the usual regularity conditions, the estimator is consistent and asymptotically normal distributed.
5.5 Elasticities
When we differentiate Eq. 4 with respect to the predictors of interest, we obtain the marginal timetopeaksales effect of that variable, which we can easily transform into an elasticitybased measure. To derive the heightofpeaksales effects, we substitute Eq. 4 into 3 and differentiate the expression with respect to the predictor variable of interest (see Appendix C for details). The formal expressions for the timeto and heightofpeaksales elasticities appear in Table 4. Because order of entry and number of competitors are noncontinuous variables, we must interpret their elasticity with care. Before we discuss the estimation outcomes we elaborate on endogeneity issues.
5.6 Endogeneity issues
Our model includes several strategic variables that may be endogenous. For example, because pharmaceutical firms decide about the timing of product launch, product quality, and the level of marketing investment taking (past) sales into account, failing to account for endogeneity can lead to biased or inconsistent parameter estimates (Franses 2005). We executed Wutests to assess whether the exogeneity assumption is violated for our included variables (Greene 2004). These tests show that (1) order of entry (OE), (2) quality (Q), (3) longterm marketing investment until timetopeaksales \( (ME{S_{{t^{PEAK}}}}) \), and (4) the number of competitors \( (N{C_{{t^{PEAK}}}}) \) are indeed endogenous (p < .01). The Wutest shows that the exogeneity assumption with respect to competitive marketing expenditures (p > .05) and comarketing expenditures (p > .05) is not violated. Hence, we estimate a reducedform model and employ instrumental variables estimation with exogenous information that identifies the firm’s strategic variables (Franses 2005) for the four variables OE, Q, \( ME{S_{{t^{PEAK}}}} \) and \( N{C_{{t^{PEAK}}}} \). For details on this procedure, we refer to Appendix D.
One alternative way to deal with endogeneity issues would be to model firm interactions in an equilibrium framework (e.g., Chintagunta et al. 2006). Given the long time horizon of 10–12 years required to develop a new drug and the uncertainties associated with the outcomes of clinical trials and the approval process, an appropriate model would feature the solution to a dynamic stochastic game among 8 to 10 firms that decide about entry timing, quality, and longterm marketing investments. Such a model is beyond the scope of this paper.
6 Estimation results
6.1 Model fit
We present the estimation results for the brandsales model applied to the eight product markets in Table 5. Model fit is very good. To assess the insample and outofsample fit, we exclude the last four quarters of year 1996 from estimation. Squared correlation between predicted and actual values of the dependent variable amount to .969 in the estimation sample (1,206 observations) and .941 in the holdout sample (180 observations).^{Footnote 3} Table 5 includes the estimated means and standard deviations of the distributions for heterogeneous parameters. All estimates for which we explicitly predict the direction of the effect show the expected sign.
We also check for serial correlation in the error term but do not find evidence for it. The autocorrelation coefficient is .048 (p = .605). Note that sales dynamics are implicit to the definition of our stock variables (see Table 2 again). In addition, we explicitly model growth dynamics in Eq. 1.
6.2 Model comparison
In the existing literature, there are several competing sales growth models including diffusion models and parametric growth models. We compare the selected model with alternative parametric growth models that can be derived from Bertalanffy’s growth theory. Specifically, we consider the model used by Shankar et al. (1999) for pharmaceuticals and a model that represents a symmetric sales evolution and is comparable to the Bass model. According to the Bayesian Information Criterion, the model turned out to be inferior (−1,455.8_{proposed} vs. −1,592.0_{symmetric} vs. −1,594.5_{Shankar et al.}). The squared correlations of predicted and actual values of the citerion variables in the estimation and holdout samples also appear to be lower (.900/.886 for the symmetric model and .961/.936 for the Shankar et. al. model). Hence, we conclude that for our data, Brockhoff’s model best represents the brand growth process.^{Footnote 4}
Another alternative model is the one suggested by Fok and Franses (2007), which represents an extension of the Bass model (see also Boswijk and Franses 2005). As noted earlier, their model studies timetopeakcitations and peak citations. Specifically, they propose a multilevel regression model to measure determinants of these two citation metrics. Our model is similar to theirs as we also propose a multilevel regression model using the same estimation technique (simulated maximum likelihood). Our model is, however, more parsimonious as we only have one secondlevel equation, while their approach requires estimating four of such equations. Importantly, the Fok and Franses diffusion model is specified in terms of cumulated brands sales, which we do not observe for brands earlier than the start of our observation period. Although we cannot use the full sample, we calibrate and compare the extended Bass model with our suggested model in a reduced sample of 26 brands (635 observations). Since both models are calibrated on different sets of criterion and predictor variables a direct comparison in terms of fit measures is not possible. We therefore apply the Davidson/McKinnontest (see e.g., Greene 2004). The idea of this test is to use the predicted values of the alternative model as an additional predictor adding potentially relevant new information to the focal model. The test is inconclusive for our data, i.e. the two models are not superior to each other. The advantage of our proposed model is, however, that it can be applied to the full sample.
6.3 Timetopeaksales process function
We find a negative main effect of order of entry on timetopeaksales (α_{1} = −.373, p < .05), indicating that later entrants achieve their peak sales earlier, consistent with our expectation. This result also complements previous findings regarding the impact of order of entry on brand growth (Kalyanaram and Urban 1992). The main effect of quality is negative, which implies that a quality improvement reduces timetopeaksales (α_{2} = −1.83, p < .05); we proposed arguments in favor of both directions. The interaction effect between quality and order of entry, however, is positive (α_{3} = .354, p < .05). That is, a higher quality limits the negative effect of order of entry on timetopeaksales. The total effect of a change in entry order (quality) for a brand, given a certain quality (entry order position), can be assessed by calculating the elasticities of Table 4 (see Section 6.5.1).
We find a positive impact of the stock of own marketing expenditures on timetopeaksales (α_{4} = .077, p < .05). The effect of the stock of competitive marketing expenditures is not significant (α_{5} = .020, p > .05). Consistent with our expectation, we find a negative timetopeaksales effect for the number of competitors within the market (α_{6} = −.184, p < .05).
6.4 Brand sales level
Consistent with prior research, we find a significant negative direct impact of order of entry on sales (β_{1} = −.589, p < .05). The estimated value is close to its generalized value of −.50 (Kalyanaram et al. 1995). Quality has a strong and positive influence on sales (β_{2} = 2.49, p < .05), in support of our expectation. For price, we find a negative but inelastic coefficient, which confirms our expectation (β_{3} = −.321, p < .05). Recall that in our dataset price mainly varies across cross sections. We also find a positive impact of the stock of own marketing expenditures on sales (γ_{1} = .346, p < .05) but a negative effect of the stock of competitive marketing expenditures (γ_{2} = −.155, p < .05). Finally, the impact of the stock of comarketing expenditures on sales is positive and significant (γ_{3} = .012, p < .05). These marketing expenditure variable estimates refer to average effects. The large standard deviation associated with the effect of comarketing activities reveals that some brands suffer from cannibalization effects (i.e., γ_{3kli }<0 for some i).
6.5 Estimated peaksales elasticities
6.5.1 Timetopeaksales elasticities
Following Table 4, we compute peaksales effects in terms of elasticities to make results comparable across variables. Recall that these estimates are not directly available from the parameter estimates of the brand sales model in Table 5 and may differ across brands. We report the average effect over all brands in our sample. As we show in Table 6, the elasticities of timetopeaksales with respect to order of entry (= −.126, p < .05) and quality (= −.264, p < .05) are negative. That is, for the average brand, an increase in these variables reduces the time until it reaches peak sales. The elasticity of quality is greatest in terms of absolute value; this result is based on the average orderofentry position in our data, which is between 4 and 5. The stock of own marketing expenditures depicts a positive timetopeaksales elasticity (=.099, p < .05). Hence, for the average brand, marketing investments prolong the time span until peak sales. Finally, we find a significant negative elasticity of timetopeaksales associated with the number of competitors in the market (= −.235, p < .05). The elasticity of the stock of competitive marketing expenditures is not significant (= .025, p > .05).
6.5.2 Heightofpeaksales elasticities
Quality elasticity is greatest in absolute value (= 2.06, p < .05), followed by the negative orderofentry elasticity (= −.796, p < .05) and the positive elasticity with respect to the stock of own marketing expenditures (= .507, p < .05). Note, however, that the elasticity of the actual expenditure level, which is required to achieve a certain stock level, is lower. Multiplying the stock elasticity by the estimated depreciation factor \( \hat{\varphi } = .460 \), we obtain a value of .233. Competitive marketing activity has the smallest effect on heightofpeaksales but is nevertheless substantial (= −.114, p < .05). In summary, quality, order of entry, and own marketing expenditures emerge as significant drivers of the heightofpeaksales, underlining the importance of these strategic variables in the pharmaceutical industry.
6.6 Robustness
We perform several analyses to check the robustness of our findings. First, we investigate the robustness of the results against collinear influences, focusing on order of entry, quality, and their interaction. To determine whether multicollinearity has a destabilizing influence on the parameter estimates, we regress OOE, Q, and OOE×Q on either OOE or Q or both of them. The residuals from these regressions alternatively might be used in model estimation (Hill and Adkins 2003). The consistent and collinearityfree estimates confirm the results reported in Table 5. Note that we need to exclude the number of competitors and the interaction of order of entry with quality from the brand sales equation due to collinearity issues. Using the above described procedure, we obtain collinearityfree estimates for these variables that are consistent with our expectation.
Second, we check whether our results may be driven by the composition of the sample by applying the model to five new samples. The first sample consists only of brands launched during our observation period, which eliminates the issue of left truncation. In the second sample, we eliminate the pioneer brand to control for a possible sample bias that might arise from the long lead time of the pioneer. In the third and fourth samples, we apply more conservative rules to classify brands that have passed their peak sales, leading to reduced sizes of 40 and 36 brands, respectively. The last sample contains all 73 brands, including brands that have not achieved peak sales yet. In this case, we must exclude the stock of own and competitive marketing expenditures from the process function in Eq. 4 because we do not observe these quantities for all brands. The results do not change substantially, which underlines the robustness of our findings.
Third, we regress observed timeto and heightofpeaksales on our focal drivers in a crosssectional regression that covers the 45 brands of our sample (see also Section 7 and Table 7). We find significant effects for several drivers, consistent with our results from the full model. Note that these crosssectional regressions test the effects on peaksales metrics without making any assumptions about the functional form of the growth model, which provides evidence that our results are not driven by the type of growth model.
Fourth, we check whether the model improves if we include quality dimensions separately or use an unbalanced weighting scheme for the composite measure. We do not find evidence for model improvement. We also check to what extent results change if we define quality as a timevarying measure by dividing the quality index of a brand by the average quality of all competitors in the market. Results are very stable. This is because quality is by large a crosssectional phenomenon in our data. Crosssectional variation accounts for 92% in total variance for the timevarying quality measure.
7 Crosssectional analysis of new product performance
A basic premise of this article is that the two suggested peak sales metrics are highly relevant for explaining new product success in the pharmaceutical industry. In this section, we test whether this premise holds for the 45 brands in our sample. For that purpose, we regress cumulative brand (unit) sales and cumulative discounted brand cash flows (DCF) as measures of new product performance on the two peaksales metrics and their drivers. In addition, we analyze the drivers of timeto and heightofpeaksales in this crosssectional setting.
We subtract the marketing expenditures from revenues and discount them by a quarterly rate of 3% (≈12.5% per annum) to obtain discounted cash flows (DCF). Marginal costs for new pharmaceuticals are usually very low accounting for only 1015% of revenues. They do not vary much across brands and time. The most important sources of variation are revenues and marketing expenditures which are available to us.
Table 7 shows the results of the four crosssectional regressions. Standard errors are Whitecorrected to account for crosssectional heteroskedasticity (Greene 2004) and endogenous variables are instrumented as reported earlier. We discuss first results for the two peaksales metrics. Specifications are consistent with Eqs. 3 and 4. By definition, the dynamic brand sales function produces the heightofpeaksales by including timetopeaksales into the vector of arguments (see Appendix C again). Hence, it is part of the predictor set for the heightofpeaksales regression in Table 7.
Overall, the results strongly support the findings of Table 5. We note, however, that most of the coefficients related to the timetopeaksales drivers do not achieve significance. The small sample size of 45 observations together with five instrumented predictors suggests that the statistical power is not very high. The situation is less critical for heightofpeaksales as dependent variable. Here, we find a significant positive influence of timetopeaksales (elasticity of .736). Note that this finding cannot be driven by the type of growth function because we do not specify any growth function.
The last two columns of Table 7 show the results with respect to cumulative brand sales and cumulative DCF. The findings impressively suggest that both peaksales metrics are highly relevant predictors of new product success. R² is as high as .965 for cumulative brand sales and .881 for cumulative DCF. Moreover, we find that none of the driver variables such as order of entry, quality, etc. add explanatory power above and beyond the peak sales metrics. Hence, we find strong evidence for our basic premise of the relevance of peaksales metrics.
While timetopeaksales has a positive direct and indirect (via heightofpeaksales) impact on cumulative brand sales it should also have an opposite effect on cumulative DCF due to time discounting. To separate these effects we include the log of timetopeaksales in that regression and indeed find a nonmonotonic, inverted Urelationship. Based on the estimates, the turning point occurs only after several years suggesting that the negative discounting effect is not large enough to offset the positive impact of timetopeaksales on new product performance.
8 Conclusions, limitations, and future research
We suggest two new metrics of new product performance: timetopeaksales and heightofpeaksales. Our empirical analysis provides strong evidence for the power of these metrics to explain the performance of new drugs. By developing a brand sales growth model, we simultaneously model the effect of order of entry, quality, and control variables on timeto and heightofpeaksales. The estimation results provide interesting insights. Order of entry impacts both timeto and heightofpeaksales. More specifically, early entrants achieve peaksales later, and they have higher peaksales levels. Quality is also an important driver of peaksales. Highquality brands achieve peak sales earlier. In addition, higher quality is associated with a higher level of peak sales. We also study the moderating effect of quality on the orderofentry effect on timetopeaksales. Our results indicate that late entrants have longer expected timetopeaksales when they introduce a brand with high quality. Or stated differently, quality limits the negative effect of order of entry on timetopeaksales. One explanation for this finding is that due to the higher quality the late entrant is able to attract customers from early entrants increasing its adopter potential which in turn requires more time to be penetrated resulting in a longer timetopeaksales. Together these findings thus support the available notions in the literature that both order of entry and quality are important drivers of new product success.
Our results also shed some further light on the discussion on which decision variable is more important, order of entry or quality (Tellis and Johnson 2007). Our results suggest that both variables are important, as they offer the largest elasticities for timeto and heightofpeaksales compared to other variables such as competitive entries. However, peaksales elasticities with respect to quality are even higher than for order of entry. This observation complements the finding on the dominant role of quality for firm value (Tellis and Johnson 2007). However, more research is warranted to study the important tradeoff between quality and order of entry.
Our study is also subject to limitations. The estimation results hold for two (related) categories of pharmaceuticals. It would be interesting to extend the analysis to other pharmaceutical categories and even other industries. In addition, we cannot generalize our findings to alternative growth model specifications. A regression of observed timestopeak sales on our focal variables, which is not subject to specific assumptions about the growth model, finds similar results. Hence, we have much confidence that our results do not suffer from this limitation. Future research, however, should investigate to what extent peaksales metrics are influenced by specific assumptions about the growth model.
Although we analyze the effects of several important variables such as order of entry, quality, and marketing support, we do not claim they are the only important predictors of the timeto and heightofpeaksales. More research should investigate the role of other variables. The level of retail support for overthecounter drugs might be an excellent candidate in this respect. If more data were available researchers could also extend the analysis to cover total brand lifetime. Finally, in this study we specifically focused on peaksales as a key metric at the brand level. Studying other metrics goes beyond the focus of our investigation.
Notes
Let t ^{Peak} be the period of peak sales. Then, sales evolves symmetrically within the interval [t ^{Peak}2t ^{Peak}, t ^{Peak} + 2t ^{Peak}] (Mahajan et al. 1990).
The corresponding Bertalanffy differential equation is \( \frac{{d{s_i}}}{{dLC{T_i}}} = {a_i}\frac{1}{{LC{T_i}}}{s_i}  {b_i}{s_i},\;{\hbox{with}}\;{a_i},{b_i} > 0 \).
The model fit may appear unusually high for a panel data set. It reflects, however, the extensive selection of predictors and specification of brand heterogeneity in the constant and slope parameters which finally leads to a model that adapts to the specifics of each individual brand timeseries. Note that R² for a simple OLS model with homogenous coefficients already amounts to .808 reflecting the strong explanatory power of the selected predictor variables.
We also checked whether the brand timeseries show multiple peaks by visual inspection. The phenomenon occurs at the quarterly level due to shortterm sales fluctuations. Aggregated to the annual level, sales evolution appears much smoother indicating a single peak.
References
Agarwal, R., & Bayus, B. L. (2002). The market evolution and sales takeoff of product innovations. Management Science, 48(8), 1024–1041.
Ainslie, A., Drèze, X., & Zufryden, F. (2005). Modeling movie lifecycles and market share. Marketing Science, 24(3), 508–517.
Alpert, F. H., & Kamins, M. A. (1994). Pioneer brand advantage and consumer behavior: a conceptual framework and propositional inventory. Journal of the Academy of Marketing Science, 22(3), 244–253.
Bass, F. M. (1969). A new product growth model for consumer durables. Management Science, 15, 215–227.
Bauer, H. H., & Fischer, M. (2000). Product life cycle patterns for pharmaceuticals and their impact on R&D profitability of late mover products. International Business Review, 9(6), 703–725.
Bayus, B. L. (1998). An analysis of product lifetimes in a technologically dynamic industry. Management Science, 44(6), 763–775.
Berndt, E. R., Bui, L., Reily, D. R., & Urban, G. L. (1995). Information, marketing, and pricing in the U.S. antiulcer drug market. American Economic Review, Papers and Proceedings, 85(2), 100–105.
Bodapati, A., & Gupta, S. (2004). The recoverability of segmentation structure from storelevel aggregate data. Journal of Marketing Research, 41(3), 351–364.
Boswijk, H. P., & Franses, P. H. (2005). On the econometrics of the Bass diffusion model. Journal of Business and Economic Statistics, 23, 255–268.
Brockhoff, K. (1967). A test for the product life cycle. Econometrica, 35(3/4), 472–484.
Chintagunta, P. K., Erdem, T., Rossi, P. E., & Wedel, M. (2006). Structural modeling in marketing: review and assessment. Marketing Science, 26(6), 604–616.
Cooper, L. G., & Nakanishi, M. (1988). Marketshare analysis: Evaluating competitive marketing effectiveness. Boston: Kluwer Academic.
Corstjens, M., Demeire, E., & Horowitz, I. (2005). New product success in the pharmaceutical industry: how many bites at the cherry? Economics of Innovation and New Technology, 14(4), 319–331.
Cox, W. E. (1967). Product life cycles as marketing models. Journal of Business, 40(4), 375–384.
Datamonitor (2007). Orthovita: Cortoss could generate high sales in the spinal fracture market, http://www.datamonitor.com/companies/company/?pid=6FB426259E2A4DB482B126875E2D5B7C&nid=1AE201D1E6E54EAD85F2205968C4FA11&type=CommentWire&article=1 (Accessed at 1/22/2008).
Dhalla, N. K., & Yuspeh, S. (1976). Forget the product life cycle concept! Harvard Business Review, 54(1), 102–111.
Dubé, J. P., & Manchanda, P. (2005). Differences in dynamic brand competition across markets: an empirical analysis. Marketing Science, 24(1), 81–95.
Fischer, M., & Albers, S. (2010). Patient or physicianoriented marketing: what drives primary demand for prescription drugs? Journal of Marketing Research, 47(1), 103–121.
Fok, D., & Franses, P. H. (2007). Modeling the diffusion of scientific publications. Journal of Econometrics, 139, 376–390.
Franses, P. H. (2005). Diagnostics, expectations, and endogeneity. Journal of Marketing Research, 42(1), 27–29.
Gielens, K., & Dekimpe, M. G. (2001). Do international entry decisions of retail chains matter in the long run? International Journal of Research in Marketing, 18(3), 235–259.
Gielens, K., & Steenkamp, J. B. E. M. (2007). Drivers of consumer acceptance of new packaged goods: An investigation across products and countries. International Journal of Research in Marketing, 24(2), 97–112.
Goldenberg, J., Libai, B., & Muller, E. (2002). Riding the saddle: how crossmarket communications can create a major slump in sales. Journal of Marketing, 66(2), 1–16.
Golder, P. N., & Tellis, G. J. (1993). Pioneer advantage: marketing logic or marketing legend? Journal of Marketing Research, 30(2), 158–170.
Golder, P. N., & Tellis, G. J. (1997). Will it ever fly? Modeling the takeoff of really new consumer durables. Marketing Science, 16(3), 256–270.
Golder, P. N., & Tellis, G. J. (2004). Growing, growing, gone: cascades, diffusion, and turning points in the product life cycle. Marketing Science, 23(2), 207–218.
Grabowski, H., & Vernon, J. (1990). A new look at the returns and risks to pharmaceutical R&D. Management Science, 36(7), 804–821.
Greene, W. H. (2004). Econometric analysis (5th ed.). Upper Saddle River: Prentice Hall.
Hahn, M., Park, S., Krishnamurthi, L., & Zoltners, A. (1994). Analysis of new product diffusion using a foursegment trialrepeat model. Marketing Science, 13(3), 224–247.
Hauser, J. R., Tellis, G. J., & Griffin, A. (2006). Research on innovation: a review and agenda for future research. Marketing Science, 25(6), 687–717.
Hill, R. C., & Adkins, L. C. (2003). Collinearity. In B. H. Baltagi (Ed.), A companion to theoretical econometrics. Malden: Blackwell.
Horsky, D., & Simon, L. L. (1983). Advertising and the diffusion of new products. Marketing Science, 2(1), 1–18.
Kalyanaram, G., & Urban, G. L. (1992). Dynamic effects of orderofentry on market share, trial penetration, and repeat purchases for frequently purchased consumer goods. Marketing Science, 11(3), 235–250.
Kalyanaram, G., Robinson, W. T., & Urban, G. L. (1995). Order of market entry: established empirical generalizations, emerging empirical generalizations, and future research. Marketing Science, 14(3/2), G212–G221.
Kalyanaraman, G., & Wittink, D. R. (1994). Heterogeneity in entry effets between nondurable consumer product categories. International Journal of Research in Marketing, 11(3), 219–231.
Kornelis, M., Dekimpe, M. G., & Leeflang, P. S. H. (2008). Does competitive entry structurally change key marketing metrics. International Journal of Research in Marketing, 25(3), 173–182.
Kremer, S. T. M., Bijmolt, T. H. A., Leeflang, P. S. H., & Wieringa, J. E. (2008). Generalizations on the effectiveness of pharmaceutical promotional expenditures. International Journal of Resesarch in Marketing, 25(4), 234–246.
Krishnan, T. V., Bass, F. M., & Kumar, V. (2000). Impact of a late entrant on the diffusion of a new product/service. Journal of Marketing Research, 37(2), 269–278.
Leenders, A. A. M., & Wierenga, B. (2008). The effect of the marketing—R&D interface on new product performance: the critical role of resources and scope. International Journal of Research in Marketing, 25, 56–68.
Lieberman, M. B., & Montgomery, D. B. (1988). Firstmover advantages. Strategic Management Journal, 9, 41–58.
Lilien, G. L., Rao, A. G., & Kalish, S. (1981). Bayesian estimation and control of detailing effort in a repeat purchase diffusion environment. Management Science, 27(5), 493–506.
Mahajan, V., Muller, E., & Bass, F. M. (1990). New product diffusion models in marketing: a review and directions for research. Journal of Marketing, 54(1), 1–26.
Manchanda, P., Wittink, D. R., Ching, A., Cleanthous, P., Ding, M., Dong, X. J., et al. (2005). Understanding firm, physician and consumer choice behavior in the pharmaceutical industry. Marketing Letters, 16(3/4), 293–308.
McAlister, L., & Pessemier, E. (1982). Variety seeking behavior: an interdisciplinary review. Journal of Consumer Research, 9(3), 311–322.
Neelameghan, R., & Chintagunta, P. K. (2004). Modeling and forecasting the sales of technology products. Quantitative Marketing & Economics, 2(3), 195–232.
Obeid, I., & Vine, P. (2005). Pharmaceutical industry: changing paradigms, changing opportunities. EJHPJournal, 11(4), 9. Available at www.eahponline.org/upload/ejhp/InthisIssue7879.pdf.
Osinga, E. C., Leeflang, P. S. H., & Wieringa, J. E. (2010). Early marketing matters. Journal of Marketing Research, 47(1), 173–185.
Polli, R., & Cook, V. J., Jr. (1969). Validity of the product life cycle. Journal of Business, 42(4), 385–400.
Prins, R., & Verhoef, P. C. (2007). Marketing communication drivers of adoption timing of a new EService among existing customers. Journal of Marketing, 71(2), 169–183.
Rao, A. G., & Masataka, Y. (1988). Forecasting with a repeat purchase diffusion model. Management Science, 34(6), 734–752.
Robinson, W. T., & Fornell, C. (1985). Sources of market pioneer advantages in consumer goods industries. Journal of Marketing Research, 22(3), 305–317.
Rogers, E. M. (1995). Diffusion of innovations (4th ed.). New York: The Free.
Schmid, E. A., & Smith, D. A. (2002). Discovery, innovation and the cyclical nature of the pharmaceutical business. Drug Discovery Today, 7(10), 563–568.
Shankar, V., Carpenter, G. S., & Krishnamurthi, L. (1998). Late mover advantage: how innovative late entrants outsell pioneers. Journal of Marketing Research, 35(1), 54–70.
Shankar, V., Carpenter, G. S., & Krishnamurthi, L. (1999). The advantages of entry in the growth stage of the product life cycle: an empirical analysis. Journal of Marketing Research, 36(2), 269–276.
Simon, H. (1979). Dynamics of price elasticities and brand life cycles: an empirical study. Journal of Marketing Research, 16(4), 439–452.
Srivastava, R. K., Shervani, T. A., & Fahey, L. (1998). Market based assets and shareholder value: a framework for analysis. Journal of Marketing, 62(1), 2–18.
Steenkamp, J. B. E. M., & Gielens, K. (2003). Consumer and market drivers of the trial probability of new consumer packaged goods. Journal of Consumer Research, 30(3), 368–384.
Stremersch, S., & Tellis, G. J. (2004). Understanding and managing growth of international new products. International Journal of Research in Marketing, 21(4), 421–438.
Stremersch, S., & van Dyck, W. (2009). Marketing of the life sciences: a new framework and research agenda for a nascent field. Journal of Marketing, 73, 4–30.
Suresh, P., Basu P. K., & Venkatsasbramanian, V. (2006). Impact of improving pharmaceutical product development and manufacturing. Presentation for AICHE 2006, Purdue University.
Tellis, G. J., & Johnson, J. (2007). The value of quality. Marketing Science, 26(6), 758–773.
Tellis, G. J., Stremersch, S., & Yin, E. (2003). The international takeoff of new products: the role of economics, culture, and country innovativeness. Marketing Science, 22(2), 188–208.
Tradingmarkets.com (2007). Shares of Salix pharmaceuticals tumble; downgraded to sell at Piper Jaffray, available at http://www.tradingmarkets.com/.site/news/Stock%20News/948264/ (Accessed at 1/22/2008).
Urban, G. L., Carter, T., Gaskin, S., & Mucha, Z. (1986). Market share rewards to pioneering brands: an empirical analysis and strategic implications. Management Science, 32(6), 645–659.
Venkataraman, S., & Stremersch, S. (2007). The debate on influencing doctors’ decisions: are drug characteristics the missing link? Management Science, 53(11), 1688–1701.
von Bertalanffy, L. (1957). Quantitative laws in metabolism and growth. Quarterly Review of Biology, 32, 217–231.
Zhang, J., & Narasimhan, C. (2000). Market entry strategy under firm heterogeneity and symmetric payoffs. Marketing Science, 19(4), 313–327.
Acknowledgements
We are grateful to Abbot Laboratories Germany (previously Knoll AG) for providing the data used in this research. We thank Sönke Albers, Tammo Bijmolt, Michel Clement, and Kent Nakamoto and participants at the 2003 Marketing Science Conference in Maryland, Research Camp on Pharmaceutical Marketing, University of Groningen 2005, and the UCLA and USC faculty seminars for helpful comments on previous versions of this article. We acknowledge the helpful and supportive comments of the editor and reviewers.
We also are indebted to Dick Wittink, who contributed to a previous version. Dick passed away unexpectedly on June 4, 2005.
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Appendices
Appendix A
1.1 Sales volatility and growth
Assume we observe product sales s from launch until t=T*, the period when sales reach their maximum level. Assume further that sales evolve at an annual compound sales growth rate g. Denoting the sales level in the launch year (t=0) with k, we can describe sales evolution in terms of the starting level k and the annual compound growth rate g. Cumulative sales at t=T* are given by
Note that the mean E[s _{ t }]=μ of the sales timeseries, s _{ 0 }, s _{ 1 }, …, s _{ t }, …, s _{T*}, is defined as
Intuitively, the average sales level should be higher the higher the growth rate, which can be shown by differentiating (A.2) with respect to g
We can demonstrate that the variance in sales as a measure of volatility increases in the growth rate. Let us decompose the variance of sales into
Because Var (s _{ t })>0, it follows \( E\left[ {s_t^2} \right] > {\mu^2} \) and we can write for (A.4)
Differentiating (A.5) with respect to g gives
Since r > 1 and dμ/dg>0, expression (A.6) is always greater than zero. Hence, the larger the sales growth is the larger the sales volatility. If the same level of peak sales is reached in shorter time, the volatility in sales must increase.
Appendix B
2.1 Definition of the quality measure
Two healthcare professionals who work in the pharmaceutical industry compiled the data for each quality dimension for each drug from published international drug review reports. These reports are like metaanalysis reports, in that they collect combined evidence about the seven quality dimensions from studies published primarily in academic journals and summarize them. The performance measure of a drug uses different units for different dimensions: percentage (bioavailability, protein absorption), hours (plasma halflifetime), and frequency (average occurrence of side effects, number of interactions, number of indications, dosage per day). Side effects, interactions, and required dosage are reverse coded. The efficacy dimensions, bioavailability, protein absorption, and plasma halftime relate positively to efficacy, so there are no code reversals for these dimensions. The same applies to the number of indications.
The performance of a drug on each quality dimension is transformed into a value that represents its performance relative to the mean performance of all drugs in its category on that dimension. For each drug, the relative values of quality are aggregated across all dimensions to provide an overall quality index for that drug. The final results are crossvalidated by two leading doctors at a reputed university hospital. Table 8 provides the exact measurement approach for each dimension.
Let \( {\bar{X}_1},{\bar{X}_2},{\bar{X}_3},{\bar{X}_4},\bar{X}_5^\prime, \bar{X}_6^\prime, \,{\hbox{and}}\,\bar{X}_7^\prime \) denote the mean across all drugs within a category. The quality measure is then defined by taking the average of the relative drug performance across the seven dimensions, i.e. \( Q = \frac{1}{7}\left( {\frac{{{X_1}}}{{{{\bar{X}}_1}}} + \frac{{{X_2}}}{{{{\bar{X}}_2}}} + \frac{{{X_3}}}{{{{\bar{X}}_3}}} + \frac{{{X_4}}}{{{{\bar{X}}_4}}} + \frac{{X_5^\prime }}{{\bar{X}_5^\prime }} + \frac{{X_6^\prime }}{{\bar{X}_6^\prime }} + \frac{{X_7^\prime }}{{\bar{X}_7^\prime }}} \right) \).
Appendix C
3.1 Derivation of peaksales elasticities
The timetopeaksales and heightofpeaksales effects in Table 4 are derived according to the method described below. Without loss of generality, we demonstrate the derivation with respect to order of entry. We calculate the effect for the average brand in our sample; mean values are indicated with a bar over the variable.

(1)
Timetopeaksales elasticity
For ease of exposition, we omit the brand, category, country, and time subscripts. We define the timetopeaksales effect of order of entry as the change in timetopeaksales due to a change in the order of entry. We treat order of entry as a continuous variable. Hence, we take the first derivative of Eq. 4 with respect to OE:
To express Eq. C.1 in terms of an elasticity measure, \( {\varepsilon_{\psi, OE}} \), we multiply it by \( {{{\overline {OE} }} \left/ {{\bar{\psi }}} \right.} \):
Note that we do not estimate the parameters α_{ 1 } and α_{ 3 } directly but rather estimate their product with the average growth parameter (after substituting Eq. 4 into 3). Define \( {c_1} = \bar{b}{\alpha_1} \) and \( {c_3} = \bar{b}{\alpha_3} \). Because we estimate c _{ 1 }, c _{ 3 }, and \( \bar{b} \), we can apply the delta method to obtain the standard error for expression (C.2):

(2)
Heightofpeaksales elasticity
Define LCT=Ψ in Eq. 3, substitute Eq. 4 into this expression, and differentiate with respect to OE:
Substitute Eq. C.1 into C.4 and multiply by s ^{PEAK} to obtain the marginal effect:
Multiplying Eq. C.5 by \( {{{\overline {OE} }} \left/ {{{{\bar{s}}^{PEAK}}}} \right.} \)gives the elasticity measure in Table 4:
Given that \( \bar{b}{\alpha_1} = {c_1},\,\bar{b}{\alpha_3} = {c_3},\,\bar{b} \), and β _{ 1 } are directly estimated, Eq. C.6 is a linear combination of random variables, and a standard error estimate is readily available:
Appendix D
4.1 Procedure of instrumental variables estimation
Our instrumental variables estimation approach follows a multistage procedure. In the following, we describe for each instrumented variable how we proceed to obtain the respective instrumental variable that is used in the final estimation step whose results are reported in Table 5.
Quality
We regress the quality variable on firm dummies. Specifically, we regress the quality ratings of 73 brands on 10 firm dummies. R² amounts to .305. The predicted values of this regression are used as instrumental variable for quality and log(quality) (after log transformation).
Order of entry
We regress the orderofentry variable on the variables listed in Table 9. To account for the ordinal nature of the dependent variable, we use an ordered probit model. Quality and market share are, however, themselves endogenous and need to be instrumented for use in the orderofentry equation. We have already reported on the instruments used for quality. For market share, we regress the log of market share on brand dummies, the log of price, and the log of the stocks of own marketing expenditures, competitive marketing expenditures, and comarketing expenditures. R² amounts to .850. We take the antilog of the predicted value in the last period observed for each brand as instrumental variable for the (expected) longterm market share. Table 9 shows the estimation results for the final orderofentry regression. From this regression, we obtain the predicted order of entry for each brand which is further used as instrumental variable in the final estimation equation. Squared rank correlation (pseudo R²) of predicted with actual values amounts to .464.
Longterm marketing expenditures
We regress the stock of own marketing expenditures at the time of peak sales on the marketing expenditures of the fourth quarter of the preceding year. R² amounts to .607. The log of predicted values of this regression are used as observations for an instrumental variable for log(longterm marketing expenditures).
Number of competitors
We regress the log of the number of competitors in a category on the log of the average number of competitors in this category in the remaining three countries. R² amounts to .781. The predicted values of this regression are used as observations for the instrumental variable in the final estimation step.
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Fischer, M., Leeflang, P.S.H. & Verhoef, P.C. Drivers of peak sales for pharmaceutical brands. Quant Mark Econ 8, 429–460 (2010). https://doi.org/10.1007/s1112901090895
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DOI: https://doi.org/10.1007/s1112901090895