Abdullahi UF, Igwenagu E, Mu’azu A, Aliyu S, Umar MI (2016) Intrigues of biofilm: a perspective in veterinary medicine. Veterinary World 9:12–18
Article
CAS
PubMed
PubMed Central
Google Scholar
Abreu AC, McBain AJ, Simoes M (2012) Plants as sources of new antimicrobials and resistance-modifying agents. Nat Prod Rep 29:1007–1021
Article
CAS
PubMed
Google Scholar
Aherne SA, O’Brien NM (2002) Dietary flavonols: chemistry, food content, and metabolism. Nutrition 18:75–81
Article
CAS
PubMed
Google Scholar
Ahmed SI, Hayat MQ, Tahir M, Mansoor Q, Ismail M, Keck K, Bates RB (2016) Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl. BMC Complement Altern Med 16:460
Article
CAS
PubMed
PubMed Central
Google Scholar
Akilandeswari K, Ruckmani K (2016) Synergistic antibacterial effect of apigenin with beta-lactam antibiotics and modulation of bacterial resistance by a possible membrane effect against methicillin resistant Staphylococcus aureus. Cell Mol Biol (Noisy-le-grand) 62:74–82
Article
CAS
Google Scholar
Aldred KJ, Kerns RJ, Osheroff N (2014) Mechanism of quinolone action and resistance. Biochemistry 53:1565–1574
Article
CAS
PubMed
Google Scholar
Anderson ER, Lovin ME, Richter SJ, Lacey EP (2013) Multiple Plantago species (Plantaginaceae) modify floral reflectance and color in response to thermal change. Am J Bot 100:2485–2493
Article
PubMed
Google Scholar
Aparna V, Dineshkumar K, Mohanalakshmi N, Velmurugan D, Hopper W (2014) Identification of natural compound inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in silico high-throughput virtual screening and in vitro validation. PLoS ONE 9:e101840
Article
CAS
PubMed
PubMed Central
Google Scholar
Appelbaum PC (2012) 2012 and beyond: potential for the start of a second pre-antibiotic era? J Antimicrob Chemother 67:2062–2068
Article
CAS
PubMed
Google Scholar
Arora A, Byrem TM, Nair MG, Strasburg GM (2000) Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids. Arch Biochem Biophys 373:102–109
Article
CAS
PubMed
Google Scholar
Awolola GV, Koorbanally NA, Chenia H, Shode FO, Baijnath H (2014) Antibacterial and anti-biofilm activity of flavonoids and triterpenes isolated from the extracts of Ficus Sansibarica warb. Subsp. Sansibarica (Moraceae) extracts. Afr J Tradit Complement Altern Med 11:124–131
Article
CAS
PubMed
PubMed Central
Google Scholar
Awouafack MD, Spiteller P, Lamshoft M, Kusari S, Ivanova B, Tane P, Spiteller M (2011) Antimicrobial isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora. J Nat Prod 74:272–278
Article
CAS
PubMed
Google Scholar
Bagla VP, McGaw LJ, Elgorashi EE, Eloff JN (2014) Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves. BMC Complement Altern Med 14:383
Article
PubMed
PubMed Central
Google Scholar
Bakar NS, Zin NM, Basri DF (2012) Synergy of flavone with vancomycin and oxacillin against vancomycin-intermediate Staphyloccus aureus. Pak J Pharm Sci 25:633–638
CAS
PubMed
Google Scholar
Baldim JL, de Alcantara BGV, Domingos ODS, Soares MG, Caldas IS, Novaes RD, Oliveira TB, Lago JHG, Chagas-Paula DA (2017) The correlation between chemical structures and antioxidant, prooxidant, and antitrypanosomatid properties of flavonoids. Oxid Med Cell Longev 2017:3789856
Article
CAS
PubMed
PubMed Central
Google Scholar
Bame JR, Graf TN, Junio HA, Bussey RO, Jarmusch SA, El-Elimat T, Falkinham JO, Oberlies NH, Cech RA, Cech NB (2013) Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor. Planta Med 79:327–329
Article
CAS
PubMed
PubMed Central
Google Scholar
Barboza TJS, Ferreira AF, Ignácio ACPR, Albarello N (2016) Cytotoxic, antibacterial and antibiofilm activities of aqueous extracts of leaves and flavonoids occurring in Kalanchoe pinnata (Lam.) Pers. J Med Plants Res 10:763–770
Article
CAS
Google Scholar
Basile A, Conte B, Rigano D, Senatore F, Sorbo S (2010) Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. J Med Food 13:189–195
Article
CAS
PubMed
Google Scholar
Baugh S, Ekanayaka AS, Piddock LJ, Webber MA (2012) Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm. J Antimicrob Chemother 67:2409–2417
Article
CAS
PubMed
Google Scholar
Bay DC, Rommens KL, Turner RJ (2008) Small multidrug resistance proteins: a multidrug transporter family that continues to grow. Biochim Biophys Acta 1778:1814–1838
Article
CAS
PubMed
Google Scholar
Beck S, Stengel J (2016) Mass spectrometric imaging of flavonoid glycosides and biflavonoids in Ginkgo biloba L. Phytochemistry 130:201–206
Article
CAS
PubMed
Google Scholar
Bhosle A, Chandra N (2016) Structural analysis of dihydrofolate reductases enables rationalization of antifolate binding affinities and suggests repurposing possibilities. FEBS J 283:1139–1167
Article
CAS
PubMed
Google Scholar
Borges A, Abreu A, Malheiro J, Saavedra M, Simões M (2013) Biofilm prevention and control by dietary phytochemicals. In: Mendez-Vilas A (ed) Microbial pathogens and strategies for combating them: science, technology and education. Formatex Research Cente, Badajoz, pp 32–41
Google Scholar
Bouayed J, Bohn T (2010) Exogenous antioxidants—double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev 3:228–237
Article
PubMed
PubMed Central
Google Scholar
Boumendjel A (2003) Aurones: a subclass of flavones with promising biological potential. Curr Med Chem 10:2621–2630
Article
CAS
PubMed
Google Scholar
Bravo A, Anacona JR (2001) Metal complexes of the flavonoid quercetin: antibacterial properties. Transition Met Chem 26:20–23
Article
CAS
Google Scholar
Breidenstein EB, de la Fuente-Nunez C, Hancock RE (2011) Pseudomonas aeruginosa: all roads lead to resistance. Trends Microbiol 19:419–426
Article
CAS
PubMed
Google Scholar
Brown AK, Papaemmanouil A, Bhowruth V, Bhatt A, Dover LG, Besra GS (2007) Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. Microbiology 153:3314–3322
Article
CAS
PubMed
Google Scholar
Brunetti C, Di Ferdinando M, Fini A, Pollastri S, Tattini M (2013) Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans. Int J Mol Sci 14:3540–3555
Article
CAS
PubMed
PubMed Central
Google Scholar
Brynildsen MP, Winkler JA, Spina CS, MacDonald IC, Collins JJ (2013) Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production. Nat Biotechnol 31:160–165
Article
CAS
PubMed
PubMed Central
Google Scholar
Budzynska A, Rozalski M, Karolczak W, Wieckowska-Szakiel M, Sadowska B, Rozalska B (2011) Synthetic 3-arylideneflavanones as inhibitors of the initial stages of biofilm formation by Staphylococcus aureus and Enterococcus faecalis. Z Naturforsch C 66:104–114
Article
CAS
PubMed
Google Scholar
Bush K (2013) The ABCD’s of beta-lactamase nomenclature. J Infect Chemother 19:549–559
Article
CAS
PubMed
Google Scholar
Bush K, Fisher JF (2011) Epidemiological expansion, structural studies, and clinical challenges of new beta-lactamases from gram-negative bacteria. Annu Rev Microbiol 65:455–478
Article
CAS
PubMed
Google Scholar
Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA (2001) Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell 104:901–912
Article
CAS
PubMed
Google Scholar
Chabot S, Bel-Rhlid R, Chenevert R, Piche Y (1992) Hyphal growth promotion in vitro of the VA mycorrhizal fungus, Gigaspora margarita Becker and Hall, by the activity of structurally specific flavonoid compounds under CO2-enriched conditions. New Phytol 122:461–467
Article
CAS
PubMed
Google Scholar
Chen LW, Cheng MJ, Peng CF, Chen IS (2010) Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa. Chem Biodivers 7:1814–1821
Article
CAS
PubMed
Google Scholar
Chen H, Wu W, Ni M, Liu Y, Zhang J, Xia F, He W, Wang Q, Wang Z, Cao B, Wang H (2013) Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms. Int J Antimicrob Agents 42:317–321
Article
CAS
PubMed
Google Scholar
Chen L, Teng H, Xie Z, Cao H, Cheang WS, Skalicka-Woniak K, Georgiev MI, Xiao J (2018) Modifications of dietary flavonoids towards improved bioactivity: an update on structure-activity relationship. Crit Rev Food Sci Nutr 58:513–527
Article
CAS
PubMed
Google Scholar
Chinnam N, Dadi PK, Sabri SA, Ahmad M, Kabir MA, Ahmad Z (2010) Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner. Int J Biol Macromol 46:478–486
Article
CAS
PubMed
PubMed Central
Google Scholar
Cho M-H, Lee S-W (2015) Phenolic phytoalexins in rice: biological functions and biosynthesis. Int J Mol Sci 16:29120–29133
Article
CAS
PubMed
PubMed Central
Google Scholar
Choi O, Yahiro K, Morinaga N, Miyazaki M, Noda M (2007) Inhibitory effects of various plant polyphenols on the toxicity of Staphylococcal α-toxin. Microb Pathog 42:215–224
Article
CAS
PubMed
Google Scholar
Chou TH, Chen JJ, Peng CF, Cheng MJ, Chen IS (2011) New flavanones from the leaves of Cryptocarya chinensis and their antituberculosis activity. Chem Biodivers 8:2015–2024
Article
CAS
PubMed
Google Scholar
Christena LR, Subramaniam S, Vidhyalakshmi M, Mahadevan V, Sivasubramanian A, Nagarajan S (2015) Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens. RSC Adv 5:61881–61887
Article
CAS
Google Scholar
CLSI (2017) Performance standards for antimicrobial susceptibility testing, vol. CLSI supplement M100. Clinical and Laboratory Standards Institute, Wayne, PA, USA, p 224
Corti M, Palmero D, Eiguchi K (2009) Respiratory infections in immunocompromised patients. Curr Opin Pulm Med 15:209–217
Article
PubMed
Google Scholar
Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM (1995) Microbial biofilms. Annu Rev Microbiol 49:711–745
Article
CAS
PubMed
Google Scholar
Cowan MM (1999) Plant products as antimicrobial agents. Clin Microbiol Rev 12:564–582
CAS
PubMed
PubMed Central
Google Scholar
Croft AC, D’Antoni AV, Terzulli SL (2007) Update on the antibacterial resistance crisis. Med Sci Monit 13:RA103–RA118
CAS
PubMed
Google Scholar
Cushnie TP, Lamb AJ (2005) Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26:343–356
Article
CAS
PubMed
PubMed Central
Google Scholar
Cushnie TP, Lamb AJ (2011) Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents 38:99–107
Article
CAS
PubMed
Google Scholar
Cushnie TP, Hamilton VE, Lamb AJ (2003) Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports. Microbiol Res 158:281–289
Article
CAS
PubMed
Google Scholar
Cushnie TP, Hamilton VE, Chapman DG, Taylor PW, Lamb AJ (2007) Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin. J Appl Microbiol 103:1562–1567
Article
CAS
PubMed
Google Scholar
Cushnie TP, Taylor PW, Nagaoka Y, Uesato S, Hara Y, Lamb AJ (2008) Investigation of the antibacterial activity of 3-O-octanoyl-(−)-epicatechin. J Appl Microbiol 105:1461–1469
Article
CAS
PubMed
Google Scholar
Daigle DM, McKay GA, Thompson PR, Wright GD (1999) Aminoglycoside antibiotic phosphotransferases are also serine protein kinases. Chem Biol 6:11–18
Article
CAS
PubMed
Google Scholar
Dar KB, Bhat AH, Amin S, Anees S, Masood A, Zargar MI, Ganie SA (2016) Efficacy of aqueous and methanolic extracts of Rheum spiciformis against pathogenic bacterial and fungal strains. J Clin Diagn Res 10:BC18–BC22
CAS
PubMed
PubMed Central
Google Scholar
Delehanty JB, Johnson BJ, Hickey TE, Pons T, Ligler FS (2007) Binding and neutralization of lipopolysaccharides by plant proanthocyanidins. J Nat Prod 70:1718–1724
Article
CAS
PubMed
Google Scholar
Dey D, Ray R, Hazra B (2015) Antimicrobial activity of pomegranate fruit constituents against drug-resistant Mycobacterium tuberculosis and beta-lactamase producing Klebsiella pneumoniae. Pharm Biol 53:1474–1480
Article
CAS
PubMed
Google Scholar
Djouossi MG, Tamokou JD, Ngnokam D, Kuiate JR, Tapondjou LA, Harakat D, Voutquenne-Nazabadioko L (2015) Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk (Salicaceae). BMC Complement Altern Med 15:134
Article
CAS
PubMed
PubMed Central
Google Scholar
Domenech-Sanchez A, Martinez-Martinez L, Hernandez-Alles S, del Carmen Conejo M, Pascual A, Tomas JM, Alberti S, Benedi VJ (2003) Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance. Antimicrob Agents Chemother 47:3332–3335
Article
CAS
PubMed
PubMed Central
Google Scholar
Donhofer A, Franckenberg S, Wickles S, Berninghausen O, Beckmann R, Wilson DN (2012) Structural basis for TetM-mediated tetracycline resistance. Proc Natl Acad Sci U S A 109:16900–16905
Article
PubMed
PubMed Central
Google Scholar
Dostal AM, Samavat H, Bedell S, Torkelson C, Wang R, Swenson K, Le C, Wu AH, Ursin G, Yuan JM, Kurzer MS (2015) The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea trial. Food Chem Toxicol 83:26–35
Article
CAS
PubMed
PubMed Central
Google Scholar
Dwyer DJ, Belenky PA, Yang JH, MacDonald IC, Martell JD, Takahashi N, Chan CTY, Lobritz MA, Braff D, Schwarz EG, Ye JD, Pati M, Vercruysse M, Ralifo PS, Allison KR, Khalil AS, Ting AY, Walker GC, Collins JJ (2014) Antibiotics induce redox-related physiological alterations as part of their lethality. Proc Natl Acad Sci USA 111:E2100–E2109
Article
CAS
PubMed
PubMed Central
Google Scholar
Dzoyem JP, Hamamoto H, Ngameni B, Ngadjui BT, Sekimizu K (2013) Antimicrobial action mechanism of flavonoids from Dorstenia species. Drug Discov Ther 7:66–72
CAS
PubMed
Google Scholar
Edziri H, Mastouri M, Mahjoub MA, Mighri Z, Mahjoub A, Verschaeve L (2012) Antibacterial, antifungal and cytotoxic activities of two flavonoids from Retama raetam flowers. Molecules 17:7284–7293
Article
CAS
PubMed
PubMed Central
Google Scholar
El-Adawi H (2012) Inhibitory effect of grape seed extract (GSE) on cariogenic bacteria. J Med Plants Res 6:4883–4891
Article
Google Scholar
Elmasri WA, Zhu R, Peng W, Al-Hariri M, Kobeissy F, Tran P, Hamood AN, Hegazy MF, Pare PW, Mechref Y (2017) Multitargeted flavonoid inhibition of the pathogenic bacterium Staphylococcus aureus: a proteomic characterization. J Proteome Res 16:2579–2586
Article
CAS
PubMed
Google Scholar
Eumkeb G, Sakdarat S, Siriwong S (2010) Reversing beta-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime. Phytomedicine 18:40–45
Article
CAS
PubMed
Google Scholar
Eumkeb G, Siriwong S, Phitaktim S, Rojtinnakorn N, Sakdarat S (2012) Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli. J Appl Microbiol 112:55–64
Article
CAS
PubMed
Google Scholar
Ezraty B, Vergnes A, Banzhaf M, Duverger Y, Huguenot A, Brochado AR, Su S-Y, Espinosa L, Loiseau L, Py B, Typas A, Barras F (2013) Fe–S cluster biosynthesis controls uptake of aminoglycosides in a ROS-less death pathway. Science 340:1583–1587
Article
CAS
PubMed
Google Scholar
Falcone Ferreyra ML, Rius SP, Casati P (2012) Flavonoids: biosynthesis, biological functions, and biotechnological applications. Front Plant Sci 3:222
CAS
PubMed
PubMed Central
Google Scholar
Fang Y, Lu Y, Zang X, Wu T, Qi X, Pan S, Xu X (2016) 3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors. Sci Rep 6:23634
Article
CAS
PubMed
PubMed Central
Google Scholar
Farha MA, Brown ED (2013) Discovery of antibiotic adjuvants. Nat Biotechnol 31:120–122
Article
CAS
PubMed
Google Scholar
Fathima A, Rao JR (2016) Selective toxicity of Catechin—a natural flavonoid towards bacteria. Appl Microbiol Biotechnol 100:6395–6402
Article
CAS
PubMed
Google Scholar
Fernández L, Hancock REW (2012) Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. Clin Microbiol Rev 25:661–681
Article
CAS
PubMed
PubMed Central
Google Scholar
French GL (2006) Bactericidal agents in the treatment of MRSA infections–the potential role of daptomycin. J Antimicrob Chemother 58:1107–1117
Article
CAS
PubMed
Google Scholar
Fujita M, Shiota S, Kuroda T, Hatano T, Yoshida T, Mizushima T, Tsuchiya T (2005) Remarkable synergies between baicalein and tetracycline, and baicalein and β-lactams against methicillin-resistant Staphylococcus aureus. Microbiol Immunol 49:391–396
Article
CAS
PubMed
Google Scholar
Gardete S, Tomasz A (2014) Mechanisms of vancomycin resistance in Staphylococcus aureus. J Clin Invest 124:2836–2840
Article
CAS
PubMed
PubMed Central
Google Scholar
Gatto MT, Falcocchio S, Grippa E, Mazzanti G, Battinelli L, Nicolosi G, Lambusta D, Saso L (2002) Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters. Bioorg Med Chem 10:269–272
Article
CAS
PubMed
Google Scholar
Girish KS, Kemparaju K (2007) The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci 80:1921–1943
Article
CAS
PubMed
Google Scholar
Gledhill JR, Montgomery MG, Leslie AG, Walker JE (2007) Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. Proc Natl Acad Sci USA 104:13632–13637
Article
CAS
PubMed
PubMed Central
Google Scholar
Griep MA, Blood S, Larson MA, Koepsell SA, Hinrichs SH (2007) Myricetin inhibits Escherichia coli DnaB helicase but not primase. Bioorg Med Chem 15:7203–7208
Article
CAS
PubMed
Google Scholar
Haraguchi H, Tanimoto K, Tamura Y, Mizutani K, Kinoshita T (1998) Mode of antibacterial action of retrochalcones from Glycyrrhiza inflata. Phytochemistry 48:125–129
Article
CAS
PubMed
Google Scholar
Harborne JB, Baxter H (1999) The handbook of natural flavonoids. Wiley, New York
Google Scholar
Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. Phytochemistry 55:481–504
Article
CAS
PubMed
Google Scholar
Hartmann M, Berditsch M, Hawecker J, Ardakani MF, Gerthsen D, Ulrich AS (2010) Damage of the bacterial cell envelope by antimicrobial peptides gramicidin S and PGLa as revealed by transmission and scanning electron microscopy. Antimicrob Agents Chemother 54:3132–3142
Article
CAS
PubMed
PubMed Central
Google Scholar
Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45:2179–2205
Article
CAS
PubMed
Google Scholar
Hassan KA, Jackson SM, Penesyan A, Patching SG, Tetu SG, Eijkelkamp BA, Brown MH, Henderson PJF, Paulsen IT (2013) Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins. Proc Natl Acad Sci USA 110:20254–20259
Article
CAS
PubMed
PubMed Central
Google Scholar
Hatier JHB, Gould KS (2009) Anthocyanin function in vegetative organs. In: Gould KS, Davies K, Winefield C (eds) Anthocyanins. Springer, New York, pp 1–19
Google Scholar
Havsteen B (1983) Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 32:1141–1148
Article
CAS
PubMed
Google Scholar
Havsteen BH (2002) The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96:67–202
Article
CAS
PubMed
Google Scholar
Hayet E, Maha M, Samia A, Mata M, Gros P, Raida H, Ali MM, Mohamed AS, Gutmann L, Mighri Z, Mahjoub A (2008) Antimicrobial, antioxidant, and antiviral activities of Retama raetam (Forssk.) Webb flowers growing in Tunisia. World J Microbiol Biotechnol 24:2933–2940
Article
Google Scholar
Hendler SS, Rorvik DR (2009) PDR for nutritional supplements. Montvale, Medical Economics Data, U.S
Google Scholar
Hertel W, Peschel G, Ozegowski J-H, Müller P-J (2006) Inhibitory effects of triterpenes and flavonoids on the enzymatic activity of hyaluronic acid-splitting enzymes. Arch Pharm 339:313–318
Article
CAS
Google Scholar
Hiramatsu K (2001) Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance. Lancet Infect Dis 1:147–155
Article
CAS
PubMed
Google Scholar
Hobman JL, Crossman LC (2015) Bacterial antimicrobial metal ion resistance. J Med Microbiol 64:471–497
Article
CAS
PubMed
Google Scholar
Ikigai H, Nakae T, Hara Y, Shimamura T (1993) Bactericidal catechins damage the lipid bilayer. Biochim Biophys Acta 1147:132–136
Article
CAS
PubMed
Google Scholar
International Union of Pure and Applied Chemistry (1993) A Guide to IUPAC nomenclature of organic compounds: recommendations 1993. Blackwell Scientific Publications, Oxford
Google Scholar
Iwashina T (2003) Flavonoid function and activity to plants and other organisms. Biol Sci Space 17:24–44
Article
PubMed
Google Scholar
Jamal M, Ahmad W, Andleeb S, Jalil F, Imran M, Nawaz MA, Hussain T, Ali M, Rafiq M, Kamil MA (2018) Bacterial biofilm and associated infections. J Chin Med Assoc 81:7–11
Article
PubMed
Google Scholar
Jeong KW, Lee JY, Kang DI, Lee JU, Shin SY, Kim Y (2009) Screening of flavonoids as candidate antibiotics against Enterococcus faecalis. J Nat Prod 72:719–724
Article
CAS
PubMed
Google Scholar
Kariu T, Nakao R, Ikeda T, Nakashima K, Potempa J, Imamura T (2016) Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids. J Periodontal Res 52:89–96
Article
CAS
PubMed
PubMed Central
Google Scholar
Karlíčková J, Macáková K, Říha M, Pinheiro LMT, Filipský T, Horňasová V, Hrdina R, Mladěnka P (2015) Isoflavones reduce copper with minimal impact on iron in vitro. Oxid Med Cell Longev 2015:11
Article
CAS
Google Scholar
Kasprzak MM, Erxleben A, Ochocki J (2015) Properties and applications of flavonoid metal complexes. RSC Adv 5:45853–45877
Article
CAS
Google Scholar
Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ (2007) A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130:797–810
Article
CAS
PubMed
Google Scholar
Kon K, Rai M (2016) Antibiotic resistance: mechanisms and new antimicrobial approaches. Academic Press, USA
Google Scholar
Kopacz M, Woznicka E, Gruszecka J (2005) Antibacterial activity of morin and its complexes with La(III), Gd(III) and Lu(III) ions. Acta Pol Pharm 62:65–67
CAS
PubMed
Google Scholar
Kragh KN, Hutchison JB, Melaugh G, Rodesney C, Roberts AEL, Irie Y, Jensen PØ, Diggle SP, Allen RJ, Gordon V, Bjarnsholt T (2016) Role of multicellular aggregates in biofilm formation. mBio 7:e00237-00216
Article
Google Scholar
Kuete V, Simo IK, Ngameni B, Bigoga JD, Watchueng J, Kapguep RN, Etoa FX, Tchaleu BN, Beng VP (2007) Antimicrobial activity of the methanolic extract, fractions and four flavonoids from the twigs of Dorstenia angusticornis Engl. (Moraceae). J Ethnopharmacol 112:271–277
Article
CAS
PubMed
Google Scholar
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J 2013:162750
Google Scholar
Kurinčič M, Klančnik A, Smole Možina S (2012) Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. Microb Drug Resist 18:492–501
Article
CAS
PubMed
Google Scholar
Lambert PA, Hammond SM (1973) Potassium fluxes, first indications of membrane damage in micro-organisms. Biochem Biophys Res Commun 54:796–799
Article
CAS
PubMed
Google Scholar
Lechner D, Gibbons S, Bucar F (2008a) Modulation of isoniazid susceptibility by flavonoids in Mycobacterium. Phytochem Lett 1:71–75
Article
CAS
Google Scholar
Lechner D, Gibbons S, Bucar F (2008b) Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis. J Antimicrob Chemother 62:345–348
Article
CAS
PubMed
Google Scholar
Leclercq R, Courvalin P (2002) Resistance to macrolides and related antibiotics in Streptococcus pneumoniae. Antimicrob Agents Chemother 46:2727–2734
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee P, Tan KS (2015) Effects of epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol 60:393–399
Article
CAS
PubMed
Google Scholar
Lee JH, Regmi SC, Kim JA, Cho MH, Yun H, Lee CS, Lee J (2011) Apple flavonoid phloretin inhibits Escherichia coli O157:H7 biofilm formation and ameliorates colon inflammation in rats. Infect Immun 79:4819–4827
Article
CAS
PubMed
PubMed Central
Google Scholar
Li BH, Tian WX (2004) Inhibitory effects of flavonoids on animal fatty acid synthase. J Biochem 135:85–91
Article
CAS
PubMed
Google Scholar
Li B-H, Zhang R, Du Y-T, Sun Y-H, Tian W-X (2006) Inactivation mechanism of the β-ketoacyl-[acyl carrier protein] reductase of bacterial type-II fatty acid synthase by epigallocatechin gallate. Biochem Cell Biol 84:755–762
Article
CAS
PubMed
Google Scholar
Li W, Atkinson GC, Thakor NS, Allas U, Lu CC, Chan KY, Tenson T, Schulten K, Wilson KS, Hauryliuk V, Frank J (2013) Mechanism of tetracycline resistance by ribosomal protection protein Tet(O). Nat Commun 4:1477
Article
CAS
PubMed
Google Scholar
Li Y, Green KD, Johnson BR, Garneau-Tsodikova S (2015) Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts. Antimicrob Agents Chemother 59:4148–4156
Article
CAS
PubMed
PubMed Central
Google Scholar
Lindsay JA (2013) Hospital-associated MRSA and antibiotic resistance-what have we learned from genomics? Int J Med Microbiol 303:318–323
Article
PubMed
Google Scholar
Lof D, Schillen K, Nilsson L (2011) Flavonoids: precipitation kinetics and interaction with surfactant micelles. J Food Sci 76:N35–N39
Article
CAS
PubMed
Google Scholar
Lopes LAA, dos Santos Rodrigues JB, Magnani M, de Souza EL, de Siqueira-Júnior JP (2017) Inhibitory effects of flavonoids on biofilm formation by Staphylococcus aureus that overexpresses efflux protein genes. Microb Pathog 107:193–197
Article
CAS
PubMed
Google Scholar
Lu M (2016) Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications. Channels (Austin) 10:88–100
Article
Google Scholar
Lubelski J, Konings WN, Driessen AJ (2007) Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria. Microbiol Mol Biol Rev 71:463–476
Article
CAS
PubMed
PubMed Central
Google Scholar
Matijašević D, Pantić M, Rašković B, Pavlović V, Duvnjak D, Sknepnek A, Nikšić M (2016) The antibacterial activity of coriolus versicolor methanol extract and its effect on ultrastructural changes of Staphylococcus aureus and Salmonella enteritidis. Front Microbiol 7:1226
Article
PubMed
PubMed Central
Google Scholar
Matsumoto Y, Kaihatsu K, Nishino K, Ogawa M, Kato N, Yamaguchi A (2012) Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate. Front Microbiol 3:53
Article
PubMed
PubMed Central
Google Scholar
Mbaveng AT, Ngameni B, Kuete V, Simo IK, Ambassa P, Roy R, Bezabih M, Etoa FX, Ngadjui BT, Abegaz BM, Meyer JJ, Lall N, Beng VP (2008) Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae). J Ethnopharmacol 116:483–489
Article
CAS
PubMed
Google Scholar
McGuinness WA, Malachowa N, DeLeo FR (2017) Vancomycin resistance in Staphylococcus aureus. Yale J Biol Med 90:269–281
CAS
PubMed
PubMed Central
Google Scholar
Mi H, Wang D, Xue Y, Zhang Z, Niu J, Hong Y, Drlica K, Zhao X (2016) Dimethyl sulfoxide protects Escherichia coli from rapid antimicrobial-mediated killing. Antimicrob Agents Chemother 60:5054–5058
Article
CAS
PubMed
PubMed Central
Google Scholar
Mills E, Dugoua JJ, Perri D, Koren G (2013) Herbal medicines in pregnancy and lactation: an evidence-based approach. CRC Press, London
Google Scholar
Mirzoeva OK, Grishanin RN, Calder PC (1997) Antimicrobial action of propolis and some of its components: the effects on growth, membrane potential and motility of bacteria. Microbiol Res 152:239–246
Article
CAS
PubMed
Google Scholar
Mishra AK, Mishra A, Kehri H, Sharma B, Pandey AK (2009) Inhibitory activity of Indian spice plant Cinnamomum zeylanicum extracts against Alternaria solani and Curvularia lunata, the pathogenic dematiaceous moulds. Ann Clin Microbiol Antimicrob 8:9
Article
PubMed
PubMed Central
Google Scholar
Mori A, Nishino C, Enoki N, Tawata S (1987) Antibacterial activity and mode of action of plant flavonoids against Proteus vulgaris and Staphylococcus aureus. Phytochemistry 26:2231–2234
Article
CAS
Google Scholar
Mun S-H, Lee Y-S, Han S-H, Lee S-W, Cha S-W, Kim S-B, Seo Y-S, Kong R, Kang D-H, Shin D-W, Kang O-H, Kwon D-Y (2015) In vitro potential effect of morin in the combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Foodborne Pathog Dis 12:545–550
Article
CAS
PubMed
Google Scholar
Munita JM, Arias CA (2016) Mechanisms of antibiotic resistance. Microbiol Spectr 4(2):1–2
CAS
Google Scholar
Narbona E, Buide ML, Casimiro-Soriguer I, Del Valle JC (2014) Polimorfismos de color floral: causas e implicaciones evolutivas. Ecosistemas 23:36–47
Article
Google Scholar
Navarro-Martinez MD, Navarro-Peran E, Cabezas-Herrera J, Ruiz-Gomez J, Garcia-Canovas F, Rodriguez-Lopez JN (2005) Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophilia. Antimicrob Agents Chemother 49:2914–2920
Article
CAS
PubMed
PubMed Central
Google Scholar
Navratilova A, Nesuta O, Vancatova I, Cizek A, Varela MR, Lopez-Aban J, Villa-Pulgarin JA, Mollinedo F, Muro A, Zemlickova H, Kadlecova D, Smejkal K (2016) C-geranylated flavonoids from Paulownia tomentosa fruits with antimicrobial potential and synergistic activity with antibiotics. Pharm Biol 54:1398–1407
Article
CAS
PubMed
Google Scholar
Newman DJ (2008) Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J Med Chem 51:2589–2599
Article
CAS
PubMed
Google Scholar
Nicotra AB, Atkin OK, Bonser SP, Davidson AM, Finnegan EJ, Mathesius U, Poot P, Purugganan MD, Richards CL, Valladares F, van Kleunen M (2010) Plant phenotypic plasticity in a changing climate. Trends Plant Sci 15:684–692
Article
CAS
PubMed
Google Scholar
Nikaido H, Takatsuka Y (2009) Mechanisms of RND multidrug efflux pumps. Biochim Biophys Acta 1794:769–781
Article
CAS
PubMed
Google Scholar
Nunes P, Demaurex N, Dinauer MC (2013) Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. Traffic 14:1118–1131
CAS
PubMed
Google Scholar
Nyila MA, Leonard CM, Hussein AA, Lall N (2012) Activity of South African medicinal plants against Listeria monocytogenes biofilms, and isolation of active compounds from Acacia karroo. S Afr J Bot 78:220–227
Article
CAS
Google Scholar
Ohemeng KA, Schwender CF, Fu KP, Barrett JF (1993) DNA gyrase inhibitory and antibacterial activity of some flavones. Bioorg Med Chem Lett 3:225–230
Article
CAS
Google Scholar
Olczak T, Simpson W, Liu X, Genco CA (2005) Iron and heme utilization in Porphyromonas gingivalis. FEMS Microbiol Rev 29:119–144
Article
CAS
PubMed
Google Scholar
Ollila F, Halling K, Vuorela P, Vuorela H, Slotte JP (2002) Characterization of flavonoid–biomembrane interactions. Arch Biochem Biophys 399:103–108
Article
CAS
PubMed
Google Scholar
O’Neill AJ, Chopra I (2004) Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques. Expert Opin Investig Drugs 13:1045–1063
Article
PubMed
Google Scholar
Ono K, Nakane H, Fukushima M, Chermann J-C, BarrÉ-Sinoussi F (1990) Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur J Biochem 190:469–476
Article
CAS
PubMed
Google Scholar
Oteiza PI, Erlejman AG, Verstraeten SV, Keen CL, Fraga CG (2005) Flavonoid-membrane Interactions: a protective role of flavonoids at the membrane surface? Clin Dev Immunol 12:19–25
Article
CAS
PubMed
PubMed Central
Google Scholar
Ottaviani JI, Balz M, Kimball J, Ensunsa JL, Fong R, Momma TY, Kwik-Uribe C, Schroeter H, Keen CL (2015) Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial. Am J Clin Nutr 102:1425–1435
Article
CAS
PubMed
Google Scholar
Ouyang J, Sun F, Feng W, Sun Y, Qiu X, Xiong L, Liu Y, Chen Y (2016) Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors in Pseudomonas aeruginosa. J Appl Microbiol 120:966–974
Article
CAS
PubMed
Google Scholar
Paczkowski JE, Mukherjee S, McCready AR, Cong JP, Aquino CJ, Kim H, Henke BR, Smith CD, Bassler BL (2017) Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing receptors. J Biol Chem 292:4064–4076
Article
CAS
PubMed
PubMed Central
Google Scholar
Pages JM, James CE, Winterhalter M (2008) The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. Nat Rev Microbiol 6:893–903
Article
CAS
PubMed
Google Scholar
Pandey AK, Kumar S (2013) Perspective on plant products as antimicrobials agents: a review. Pharmacologia 4:469–480
Article
Google Scholar
Panhwar QK, Memon S (2011) Synthesis and evaluation of antioxidant and antibacterial properties of morin complexes. J Coord Chem 64:2117–2129
Article
CAS
Google Scholar
Pao SS, Paulsen IT, Saier MH Jr (1998) Major facilitator superfamily. Microbiol Mol Biol Rev 62:1–34
CAS
PubMed
PubMed Central
Google Scholar
Pepeljnjak S, Kosalec I (2004) Galangin expresses bactericidal activity against multiple-resistant bacteria: MRSA, Enterococcus spp. and Pseudomonas aeruginosa. FEMS Microbiol Lett 240:111–116
Article
CAS
PubMed
Google Scholar
Perumal Samy R, Gopalakrishnakone P (2010) Therapeutic potential of plants as anti-microbials for drug discovery. Evid Based Complement Alternat Med 7:283–294
Article
PubMed
Google Scholar
Piasecka A, Jedrzejczak-Rey N, Bednarek P (2015) Secondary metabolites in plant innate immunity: conserved function of divergent chemicals. New Phytol 206:948–964
Article
PubMed
Google Scholar
Piddock LJ (2006) Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev 19:382–402
Article
CAS
PubMed
PubMed Central
Google Scholar
Pietta P-G (2000) Flavonoids as antioxidants. J Nat Prod 63:1035–1042
Article
CAS
PubMed
Google Scholar
Pisteli L, Giorgi I (2012) Antimicrobial action of flavonoids. In: Patra AK (ed) Dietary phytochemicals and microbes. Springer, Netherlands, pp 33–61
Chapter
Google Scholar
Plaper A, Golob M, Hafner I, Oblak M, Solmajer T, Jerala R (2003) Characterization of quercetin binding site on DNA gyrase. Biochem Biophys Res Commun 306:530–536
Article
CAS
PubMed
Google Scholar
Poole K (2005) Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56:20–51
Article
CAS
PubMed
Google Scholar
Prasad VGNV, Krishna BV, Swamy PL, Rao TS, Rao GS (2014) Antibacterial synergy between quercetin and polyphenolic acids against bacterial pathogens of fish. Asian Pac J Trop Dis 4:S326–S329
Article
CAS
Google Scholar
Prochazkova D, Bousova I, Wilhelmova N (2011) Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82:513–523
Article
CAS
PubMed
Google Scholar
Qian M, Tang S, Wu C, Wang Y, He T, Chen T, Xiao X (2015) Synergy between baicalein and penicillins against penicillinase-producing Staphylococcus aureus. Int J Med Microbiol 305:501–504
Article
CAS
PubMed
Google Scholar
Qiu J, Jiang Y, Xia L, Xiang H, Feng H, Pu S, Huang N, Yu L, Deng X (2010) Subinhibitory concentrations of licochalcone A decrease alpha-toxin production in both methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates. Lett Appl Microbiol 50:223–229
Article
CAS
PubMed
Google Scholar
Radwan MM, Rodriguez-Guzman R, Manly SP, Jacob M, Ross SA (2009) Sepicanin A—a new geranyl flavanone from Artocarpus sepicanus with activity against methicillin-resistant Staphylococcus aureus (MRSA). Phytochem Lett 2:141–143
Article
CAS
PubMed
PubMed Central
Google Scholar
Raju A, Degani MS, Khambete MP, Ray MK, Rajan MG (2015) Antifolate activity of plant polyphenols against Mycobacterium tuberculosis. Phytother Res 29:1646–1651
Article
CAS
PubMed
Google Scholar
Ramirez MS, Tolmasky ME (2010) Aminoglycoside modifying enzymes. Drug Resist Updat 13:151–171
Article
CAS
PubMed
PubMed Central
Google Scholar
Rasul A, Millimouno FM, Ali Eltayb W, Ali M, Li J, Li X (2013) Pinocembrin: a novel natural compound with versatile pharmacological and biological activities. Biomed Res Int 2013:379850
Article
CAS
PubMed
PubMed Central
Google Scholar
Rauter AP (2013) Nomenclature of flavonoids. International Union of Pure and Applied Chemistry
Ren J, Meng S, Lekka CHE, Kaxiras R (2008) Complexation of flavonoids with iron: structure and optical signatures. J Phys Chem B 112:1845–1850
Article
CAS
PubMed
Google Scholar
Rendón MAA, Saldaña Z, Erdem AL, Monteiro-Neto V, Vázquez A, Kaper JB, Puente JL, Girón JA (2007) Commensal and pathogenic Escherichia coli use a common pilus adherence factor for epithelial cell colonization. Proc Natl Acad Sci USA 104:10637–10642
Article
CAS
PubMed
PubMed Central
Google Scholar
Reygaert WC (2014) The antimicrobial possibilities of green tea. Front Microbiol 5:434
Article
PubMed
PubMed Central
Google Scholar
Riha M, Karlickova J, Filipsky T, Macakova K, Rocha L, Bovicelli P, Silvestri IP, Saso L, Jahodar L, Hrdina R, Mladenka P (2014) In vitro evaluation of copper-chelating properties of flavonoids. RSC Adv 4:32628–32638
Article
CAS
Google Scholar
Rios JL, Recio MC (2005) Medicinal plants and antimicrobial activity. J Ethnopharmacol 100:80–84
Article
CAS
PubMed
Google Scholar
Roccaro AS, Blanco AR, Giuliano F, Rusciano D, Enea V (2004) Epigallocatechin-gallate enhances the activity of tetracycline in Staphylococci by inhibiting its efflux from bacterial cells. Antimicrob Agents Chemother 48:1968–1973
Article
CAS
PubMed Central
Google Scholar
Roy R, Tiwari M, Donelli G, Tiwari V (2017) Strategies for combating bacterial biofilms: a focus on anti-biofilm agents and their mechanisms of action. Virulence 9:522–554
Article
CAS
PubMed Central
Google Scholar
Ruddock PS, Charland M, Ramirez S, López A, Neil Towers GH, Arnason JT, Liao M, Dillon J-AR (2011) Antimicrobial activity of flavonoids from Piper lanceaefolium and other colombian medicinal plants against antibiotic susceptible and resistant strains of Neisseria gonorrhoeae. Sex Transm Dis 38:82–88
Article
CAS
PubMed
Google Scholar
Rukayadi Y, Han S, Yong D, Hwang JK (2010) In vitro antibacterial activity of panduratin A against enterococci clinical isolates. Biol Pharm Bull 33:1489–1493
Article
CAS
PubMed
Google Scholar
Russo P, Del Bufalo A, Cesario A (2012) Flavonoids acting on DNA topoisomerases: recent advances and future perspectives in cancer therapy. Curr Med Chem 19:5287–5293
Article
CAS
PubMed
Google Scholar
Saleem M, Nazir M, Ali MS, Hussain H, Lee YS, Riaz N, Jabbar A (2010) Antimicrobial natural products: an update on future antibiotic drug candidates. Nat Prod Rep 27:238–254
Article
CAS
PubMed
Google Scholar
Samsonowicz M, Regulska E, Kalinowska M (2017) Hydroxyflavone metal complexes—molecular structure, antioxidant activity and biological effects. Chem Biol Interact 273:245–256
Article
CAS
PubMed
Google Scholar
Sana M, Jameel H, Rahman M (2015) Miracle remedy: inhibition of bacterial efflux pumps by natural products. J Infect Dis Ther 3:1000213
Article
CAS
Google Scholar
Sanver D, Murray BS, Sadeghpour A, Rappolt M, Nelson AL (2016) Experimental modeling of flavonoid-biomembrane interactions. Langmuir 32:13234–13243
Article
CAS
PubMed
Google Scholar
Sarma DN, Barrett ML, Chavez ML, Gardiner P, Ko R, Mahady GB, Marles RJ, Pellicore LS, Giancaspro GI, Low Dog T (2008) Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Saf 31:469–484
Article
PubMed
Google Scholar
Sato M, Fujiwara S, Tsuchiya H, Fujii T, Iinuma M, Tosa H, Ohkawa Y (1996) Flavones with antibacterial activity against cariogenic bacteria. J Ethnopharmacol 54:171–176
Article
CAS
PubMed
Google Scholar
Sato M, Tsuchiya H, Akagiri M, Takagi N, Iinuma M (1997) Growth inhibition of oral bacteria related to denture stomatitis by anti-candidal chalcones. Aust Dent J 42:343–346
Article
CAS
PubMed
Google Scholar
Sato M, Tanaka H, Tani N, Nagayama M, Yamaguchi R (2006) Different antibacterial actions of isoflavones isolated from Erythrina poeppigiana against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol 43:243–248
Article
CAS
PubMed
Google Scholar
Sawamura S, Sakane I, Satoh E, Ishii T, Shimizu Y, Nishimura M, Umehara K (2002) Isolation and determination of an antidote for botulinum neurotoxin from black tea extract. Folia Pharmacol Jap 120:116–118
Google Scholar
Schiestl FP, Johnson SD (2013) Pollinator-mediated evolution of floral signals. Trends Ecol Evol 28:307–315
Article
PubMed
Google Scholar
Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Costa FBD, Castro SLD, Ferreira VF, Lacerda MVGD, Lago JHG, Leon LL, Lopes NP, Amorim RCDN, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, Soeiro MDNC, Steindel M, Tempone AG (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases—part II. Curr Med Chem 19:2176–2228
Article
CAS
PubMed
Google Scholar
Schwarz S, Kehrenberg C, Doublet B, Cloeckaert A (2004) Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev 28:519–542
Article
CAS
PubMed
Google Scholar
Senior AE, Nadanaciva S, Weber J (2002) The molecular mechanism of ATP synthesis by F1F0-ATP synthase. Biochim Biophys Acta 1553:188–211
Article
CAS
PubMed
Google Scholar
Shadrick WR, Ndjomou J, Kolli R, Mukherjee S, Hanson AM, Frick DN (2013) Discovering new medicines targeting helicases: challenges and recent progress. J Biomol Screen 18:761–781
Article
CAS
PubMed
PubMed Central
Google Scholar
Shah PM (2005) The need for new therapeutic agents: what is the pipeline? Clin Microbiol Infect 11(Suppl 3):36–42
Article
CAS
PubMed
Google Scholar
Shah S, Stapleton PD, Taylor PW (2008) The polyphenol (−)-epicatechin gallate disrupts the secretion of virulence-related proteins by Staphylococcus aureus. Lett Appl Microbiol 46:181–185
Article
CAS
PubMed
Google Scholar
Shakya T, Stogios Peter J, Waglechner N, Evdokimova E, Ejim L, Blanchard Jan E, McArthur Andrew G, Savchenko A, Wright Gerard D (2011) A small molecule discrimination map of the antibiotic resistance kinome. Chem Biol 18:1591–1601
Article
CAS
PubMed
Google Scholar
Singh SP, Konwarh R, Konwar BK, Karak N (2013) Molecular docking studies on analogues of quercetin with d-alanine:d-alanine ligase of Helicobacter pylori. Med Chem Res 22:2139–2150
Article
CAS
Google Scholar
Siriwong S, Thumanu K, Hengpratom T, Eumkeb G (2015) Synergy and mode of action of ceftazidime plus quercetin or luteolin on Streptococcus pyogenes. Evid Based Complement Alternat Med 2015:1–12
Article
Google Scholar
Sirk TW, Brown EF, Friedman M, Sum AK (2009) Molecular binding of catechins to biomembranes: relationship to biological activity. J Agric Food Chem 57:6720–6728
Article
CAS
PubMed
Google Scholar
Smejkal K, Chudik S, Kloucek P, Marek R, Cvacka J, Urbanova M, Julinek O, Kokoska L, Slapetova T, Holubova P, Zima A, Dvorska M (2008) Antibacterial C-geranylflavonoids from Paulownia tomentosa fruits. J Nat Prod 71:706–709
Article
CAS
PubMed
Google Scholar
Soromou LW, Zhang Y, Cui Y, Wei M, Chen N, Yang X, Huo M, Balde A, Guan S, Deng X, Wang D (2013) Subinhibitory concentrations of pinocembrin exert anti-Staphylococcus aureus activity by reducing alpha-toxin expression. J Appl Microbiol 115:41–49
Article
CAS
PubMed
Google Scholar
Soto SM (2013) Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm. Virulence 4:223–229
Article
PubMed
PubMed Central
Google Scholar
Spina M, Cuccioloni M, Mozzicafreddo M, Montecchia F, Pucciarelli S, Eleuteri AM, Fioretti E, Angeletti M (2008) Mechanism of inhibition of wt-dihydrofolate reductase from E. coli by tea epigallocatechin-gallate. Proteins 72:240–251
Article
CAS
PubMed
Google Scholar
Stapleton PD, Shah S, Hamilton-Miller JM, Hara Y, Nagaoka Y, Kumagai A, Uesato S, Taylor PW (2004) Anti-Staphylococcus aureus activity and oxacillin resistance modulating capacity of 3-O-acyl-catechins. Int J Antimicrob Agents 24:374–380
Article
CAS
PubMed
Google Scholar
Stepanovic S, Antic N, Dakic I, Svabic-Vlahovic M (2003) In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs. Microbiol Res 158:353–357
Article
PubMed
Google Scholar
Sugita-Konishi Y, Hara-Kudo Y, Amano F, Okubo T, Aoi N, Iwaki M, Kumagai S (1999) Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of vero toxin from enterohemorrhagic Escherichia coli O157:H7. Biochim Biophys Acta 1472:42–50
Article
CAS
PubMed
Google Scholar
Suriyanarayanan B, Sarojini Santhosh R (2015) Docking analysis insights quercetin can be a non-antibiotic adjuvant by inhibiting Mmr drug efflux pump in Mycobacterium sp. and its homologue EmrE in Escherichia coli. J Biomol Struct Dyn 33:1819–1834
Article
CAS
PubMed
Google Scholar
Suriyanarayanan B, Shanmugam K, Santhosh R (2013) Synthetic quercetin inhibits mycobacterial growth possibly by interacting with DNA gyrase. Rom Biotechnol Lett 18:1587–1593
Google Scholar
Symeonidis A, Marangos M (2012) Iron and microbial growth. In: Priti DR (ed) Insight and control of infectious disease in global scenario. InTechOpen, London
Google Scholar
Taber HW, Mueller JP, Miller PF, Arrow AS (1987) Bacterial uptake of aminoglycoside antibiotics. Microbiol Rev 51:439–457
CAS
PubMed
PubMed Central
Google Scholar
Tajuddeen N, Sallau MS, Musa AM, Habila DJ, Yahaya SM (2014) Flavonoids with antimicrobial activity from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl. Nat Prod Res 28:1915–1918
Article
CAS
PubMed
Google Scholar
Tatsimo SJ, Tamokou Jde D, Havyarimana L, Csupor D, Forgo P, Hohmann J, Kuiate JR, Tane P (2012) Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. BMC Res Notes 5:158
Article
CAS
PubMed
PubMed Central
Google Scholar
Tereschuk ML, Riera MV, Castro GR, Abdala LR (1997) Antimicrobial activity of flavonoids from leaves of Tagetes minuta. J Ethnopharmacol 56:227–232
Article
CAS
PubMed
Google Scholar
Thongnest S, Lhinhatrakool T, Wetprasit N, Sutthivaiyakit P, Sutthivaiyakit S (2013) Eriosema chinense: a rich source of antimicrobial and antioxidant flavonoids. Phytochemistry 96:353–359
Article
CAS
PubMed
Google Scholar
Tofighi Z, Molazem M, Doostdar B, Taban P, Shahverdi AR, Samadi N, Yassa N (2015) Antimicrobial activities of three medicinal plants and investigation of flavonoids of Tripleurospermum disciforme. Iran J Pharm Res 14:225–231
CAS
PubMed
PubMed Central
Google Scholar
Tohma H, Koksal E, Kilic O, Alan Y, Yilmaz MA, Gulcin I, Bursal E, Alwasel SH (2016) RP-HPLC/MS/MS analysis of the phenolic compounds, antioxidant and antimicrobial activities of Salvia L.Species. Antioxidants (Basel) 5:38
Article
CAS
Google Scholar
Tsuchiya H (2015) Membrane interactions of phytochemicals as their molecular mechanism applicable to the discovery of drug leads from plants. Molecules 20:18923–18966
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsuchiya H, Iinuma M (2000) Reduction of membrane fluidity by antibacterial sophoraflavanone G isolated from Sophora exigua. Phytomedicine 7:161–165
Article
CAS
PubMed
Google Scholar
Ulanowska K, Tkaczyk A, Konopa G, Węgrzyn G (2006) Differential antibacterial activity of genistein arising from global inhibition of DNA, RNA and protein synthesis in some bacterial strains. Arch Microbiol 184:271–278
Article
CAS
PubMed
Google Scholar
Ulrey RK, Barksdale SM, Zhou W, van Hoek ML (2014) Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa. BMC Complement Altern Med 14:499
Article
CAS
PubMed
PubMed Central
Google Scholar
Usman Amin M, Khurram M, Khan TA, Faidah HS, Ullah Shah Z, Ur Rahman S, Haseeb A, Ilyas M, Ullah N, Umar Khayam SM, Iriti M (2016) Effects of luteolin and quercetin in combination with some conventional antibiotics against methicillin-resistant Staphylococcus aureus. Int J Mol Sci 17:1947
Article
CAS
PubMed Central
Google Scholar
Van Acker H, Coenye T (2017) The role of reactive oxygen species in antibiotic-mediated killing of bacteria. Trends Microbiol 25:456–466
Article
CAS
PubMed
Google Scholar
van Miert AS (1994) The sulfonamide-diaminopyrimidine story. J Vet Pharmacol Ther 17:309–316
Article
PubMed
Google Scholar
Vasconcelos MA, Arruda FVS, de Alencar DB, Saker-Sampaio S, Albuquerque MRJR, dos Santos HS, Bandeira PN, Pessoa ODL, Cavada BS, Henriques M, Pereira MO, Teixeira EH (2014) Antibacterial and antioxidant activities of derriobtusone a isolated from Lonchocarpus obtusus. Biomed Res Int 2014:9
Google Scholar
Vatansever F, de Melo WCMA, Avci P, Vecchio D, Sadasivam M, Gupta A, Chandran R, Karimi M, Parizotto NA, Yin R, Tegos GP, Hamblin MR (2013) Antimicrobial strategies centered around reactive oxygen species—bactericidal antibiotics, photodynamic therapy, and beyond. FEMS Microbiol Rev 37:955–989
Article
CAS
PubMed
Google Scholar
Veeresham C (2012) Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res 3:200–201
Article
PubMed
PubMed Central
Google Scholar
Veras H, Santos I, Santos A, Matias E, Leite G, Souza H, Costa J, Coutinho H (2011) Comparative evaluation of antibiotic and antibiotic modifying activity of quercetin and isoquercetin in vitro. Curr Top Nutraceut Res 9:25–30
CAS
Google Scholar
Verdrengh M, Collins LV, Bergin P, Tarkowski A (2004) Phytoestrogen genistein as an anti-staphylococcal agent. Microbes Infect 6:86–92
Article
CAS
PubMed
Google Scholar
Vikram A, Jayaprakasha GK, Jesudhasan PR, Pillai SD, Patil BS (2010) Suppression of bacterial cell–cell signalling, biofilm formation and type III secretion system by citrus flavonoids. J Appl Microbiol 109:515–527
CAS
PubMed
Google Scholar
Waglechner N, Wright GD (2017) Antibiotic resistance: it’s bad, but why isn’t it worse? BMC Biol 15:84
Article
CAS
PubMed
PubMed Central
Google Scholar
Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL (2000) Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6:909–919
Article
CAS
PubMed
Google Scholar
Wang SX, Zhang FJ, Feng QP, Li YL (1992) Synthesis, characterization, and antibacterial activity of transition metal complexes with 5-hydroxy-7,4′-dimethoxyflavone. J Inorg Biochem 46:251–257
Article
CAS
PubMed
Google Scholar
Wang SY, Sun ZL, Liu T, Gibbons S, Zhang WJ, Qing M (2014) Flavonoids from Sophora moorcroftiana and their synergistic antibacterial effects on MRSA. Phytother Res 28:1071–1076
Article
CAS
PubMed
Google Scholar
Weiner LM, Webb AK, Limbago B, Dudeck MA, Patel J, Kallen AJ, Edwards JR, Sievert DM (2016) Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014. Infect Control Hosp Epidemiol 37:1288–1301
Article
PubMed
PubMed Central
Google Scholar
Wiegand I, Hilpert K, Hancock RE (2008) Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc 3:163–175
Article
CAS
PubMed
Google Scholar
Wu D, Kong Y, Han C, Chen J, Hu L, Jiang H, Shen X (2008) d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int J Antimicrob Agents 32:421–426
Article
CAS
PubMed
Google Scholar
Wu T, Zang X, He M, Pan S, Xu X (2013) Structure-activity relationship of flavonoids on their anti-Escherichia coli activity and inhibition of DNA gyrase. J Agric Food Chem 61:8185–8190
Article
CAS
PubMed
Google Scholar
Xu H, Ziegelin G, Schroder W, Frank J, Ayora S, Alonso JC, Lanka E, Saenger W (2001) Flavones inhibit the hexameric replicative helicase RepA. Nucleic Acids Res 29:5058–5066
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu X, Zhou XD, Wu CD (2011) The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans. Antimicrob Agents Chemother 55:1229–1236
Article
CAS
PubMed
Google Scholar
Xu X, Zhou XD, Wu CD (2012) Tea catechin epigallocatechin gallate inhibits Streptococcus mutans biofilm formation by suppressing gtf genes. Arch Oral Biol 57:678–683
Article
CAS
PubMed
Google Scholar
Zhang YM, Rock CO (2004) Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase. J Biol Chem 279:30994–31001
Article
CAS
PubMed
Google Scholar
Zhang F, Luo SY, Ye YB, Zhao WH, Sun XG, Wang ZQ, Li R, Sun YH, Tian WX, Zhang YX (2008a) The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (FabG). Biotechnol Appl Biochem 51:73–78
Article
CAS
PubMed
Google Scholar
Zhang L, Kong Y, Wu D, Zhang H, Wu J, Chen J, Ding J, Hu L, Jiang H, Shen X (2008b) Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci 17:1971–1978
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao W-H, Hu Z-Q, Okubo S, Hara Y, Shimamura T (2001) Mechanism of synergy between epigallocatechin gallate and β-Lactams against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 45:1737–1742
Article
CAS
PubMed
PubMed Central
Google Scholar
Zheng WF, Tan RX, Yang L, Liu ZL (1996) Two flavones from Artemisia giraldii and their antimicrobial activity. Planta Med 62:160–162
Article
CAS
PubMed
Google Scholar