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The ABCD’s of β-lactamase nomenclature

  • Review Article
  • Published:
Journal of Infection and Chemotherapy

Abstract

β-Lactamases can be named on the basis of molecular characteristics or functional properties. Molecular classes A, B, C, and D define an enzyme according to amino acid sequence and conserved motifs. Functional groups 1, 2, and 3 are used to assign a clinically useful description to a family of enzymes, with subgroups designated according to substrate and inhibitor profiles. In addition, other designations are used to define the functionality of specific subgroups, such as extended-spectrum β-lactamases, or ESBLs, and inhibitor-resistant TEM, or IRT, β-lactamases. None of these systems provides an unambiguous description of this versatile set of enzymes. A proposed classification system involving microbiological, molecular, and biochemical properties is described, based on the traditional classes A, B, C, and D and functional groups 1, 2, and 3 designations.

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  1. Department of Molecular and Cellular Biochemistry, Indiana University Bloomington, Simon Hall 102B, 212 S. Hawthorne Dr., Bloomington, IN, 47405, USA

    Karen Bush

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Bush, K. The ABCD’s of β-lactamase nomenclature. J Infect Chemother 19, 549–559 (2013). https://doi.org/10.1007/s10156-013-0640-7

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