Skip to main content
SpringerLink
Log in

Comparative Study of the Quantitative Determination of Lappaconitine in Aconitum septentrionale by High-Performance Liquid Chromatography and Spectrophotometry

  • MEDICINAL PLANTS
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Methods for quantification of total alkaloids in terms of lappaconitine in Aconitum septentrionale Koelle, a plant raw material that is the main source for producing the antiarrhythmic drug allapinin, were comparatively analyzed. The examined methods could be used interchangeably although the spectrophotometric method was more labor- and time-intensive. The HPLC method was more selective. It was concluded that HPLC was more advantageously used than spectrophotometry for quantitative determination of total alkaloids in terms of lappaconitine in A. septentrionale.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.

Similar content being viewed by others

References

  1. B. V. Brovchenko, V. A. Ermakova, A. N. Kuz’menko, et al., Razrab. Regist. Lek. Sredstv, No. 3 (24), 162 – 165 (2018).

  2. K. N. Brenzel, Sunset Western Garden Book, Menlo Park, California (2007), pp. 606 – 607.

  3. A. L. Budantsev and E. E. Lesiovskaya, Wild Useful Plants of Russia [in Russian], Moscow (2001).

  4. A. Tsitsilin, Medicinal Plants (Atlas-Guide) [in Russian], Moscow (2015).

  5. Sh. A. Saidkhodzhaeva, I. A. Bessonova, and Z. M. Vaisov, Khim. Prir. Soedin., Spec. Iss., 5 – 7 (1999).

  6. Ph. Rasmussen, Molecules, 13, 3223 (2008).

    Google Scholar 

  7. F. N. Dzhakhangirov, “Pharmacology of diterpenoid alkaloids,” Doctoral Dissertation, Tashkent (2010).

  8. K. R. Kasymova and F. N. Dzhakhangirov, Farm. Vestn. Uzb., No. 2, 67 – 70 (2009).

  9. A. M. Nigmatullaev and K. Taizhanov, Rastit. Resur., No. 3, 357 – 362 (1988).

  10. A. Z. Sadikov and T. T. Shakirov, Khim. Prir. Soedin., No. 1, 91 – 94 (1988).

  11. F. N. Dzhakhangirov, Allapinin – A New Antiarrhythmic Herbal Preparation [in Russian], Fan, Tashkent (1993).

  12. F. N. Dzhakhangirov and S. F. Sokolov, Kardiologiya, No. 7, 96 – 102 (2002).

    Google Scholar 

  13. S. F. Sokolov, S. A. Bakalov, N. A. Mironova, et al., Kardiologiya, No. 1, 20 – 26 (2014).

    Google Scholar 

  14. A. I. Nikonova and M. S. Urusova, Izv. Ross. Voen.-Med. Akad., 39(1), 105 – 108 (2020).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77 Mirzo Ulugbek St, 100170, Tashkent, Uzbekistan

    D. K. Mutalova, Sh. A. Otaeva, A. Z. Sadikov & Sh. Sh. Sagdullaev

Authors
  1. D. K. Mutalova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sh. A. Otaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Z. Sadikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sh. Sh. Sagdullaev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. K. Mutalova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 10, pp. 27 – 31, October, 2023.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mutalova, D.K., Otaeva, S.A., Sadikov, A.Z. et al. Comparative Study of the Quantitative Determination of Lappaconitine in Aconitum septentrionale by High-Performance Liquid Chromatography and Spectrophotometry. Pharm Chem J 57, 1599–1603 (2024). https://doi.org/10.1007/s11094-024-03054-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-024-03054-9

Keywords

Search

Navigation