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Biodegradable Microparticles with Encapsulated Anti-Inflammatory Peptide Ingramon

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

A technique for encapsulating the anti-inflammatory dodecapeptide ingramon into microspheres of a biodegradable copolymer of lactic and glycolic acids (PLGA) to provide prolonged release of the peptide for up to 28 d is presented. The technique makes it possible to achieve >90% encapsulation efficiency and is suitable for producing an injectable suspension that meets the requirements of the State Pharmacopoeia of the Russian Federation. The peptide distribution inside the obtained microspheres and its release kinetics were characterized. A tendency toward suppression of JE/CCL2-dependent monocyte migration was revealed in mice with preliminary (7 d before the experiment) administration of ingramon-depot.

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Authors and Affiliations

  1. NII Mitoinzhenerii MGU LLC, 1/73 Leninskie Gory, Moscow, 119234, Russia

    N. V. Marmiy, D. S. Esipov & V. N. Tashlitsky

  2. Chazov National Medical Center of Cardiology, Ministry of Health of Russia, 15A 3rd Cherepkovskaya St., Moscow, 121552, Russia

    T. I. Arefieva, U. S. Kozhokar, M. V. Ovchinnikov, N. V. Radyukhina & M. V. Sidorova

  3. Faculty of Biology, Lomonosov Moscow State University, 1/12 Leninskie Gory, Moscow, 119234, Russia

    D. S. Esipov

  4. Faculty of Chemistry, Lomonosov Moscow State University, 1/40 Leninskie Gory, Moscow, 119991, Russia

    V. N. Tashlitsky

Authors
  1. N. V. Marmiy
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  2. T. I. Arefieva
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  3. D. S. Esipov
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  4. V. N. Tashlitsky
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  5. U. S. Kozhokar
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  6. M. V. Ovchinnikov
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  7. N. V. Radyukhina
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  8. M. V. Sidorova
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Corresponding author

Correspondence to N. V. Marmiy.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 8, pp. 59 – 66, August, 2023.

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Marmiy, N.V., Arefieva, T.I., Esipov, D.S. et al. Biodegradable Microparticles with Encapsulated Anti-Inflammatory Peptide Ingramon. Pharm Chem J 57, 1290–1297 (2023). https://doi.org/10.1007/s11094-024-03037-w

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  • DOI: https://doi.org/10.1007/s11094-024-03037-w

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