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Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

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Pharmaceutical Chemistry Journal Aims and scope

S-carboxyalkyl derivatives of 2-thiouracil were synthesized and their pharmacological activity was studied. Several of the compounds were characterized by antiglycation activity. These compounds had no effect on PPAR or glucokinase activity and had weak activity in cleaving protein crosslinks.

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Authors and Affiliations

  1. Volgograd State Medical University, Volgograd, Russia

    A. A. Spasov, A. N. Geisman, V. A. Kosolapov, D. A. Babkov, A. I. Rashchenko, V. A. Babkova, O. Yu. Zakhar’yashcheva & A. A. Ozerov

  2. Volgograd Medical Science Center, Volgograd, Russia

    A. A. Spasov, A. N. Geisman & A. A. Ozerov

Authors
  1. A. A. Spasov
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  2. A. N. Geisman
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  3. V. A. Kosolapov
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  4. D. A. Babkov
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  5. A. I. Rashchenko
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  6. V. A. Babkova
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  7. O. Yu. Zakhar’yashcheva
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  8. A. A. Ozerov
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Corresponding author

Correspondence to V. A. Kosolapov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 7, pp. 18 – 22, July, 2019.

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Spasov, A.A., Geisman, A.N., Kosolapov, V.A. et al. Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil. Pharm Chem J 53, 610–615 (2019). https://doi.org/10.1007/s11094-019-02047-3

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  • DOI: https://doi.org/10.1007/s11094-019-02047-3

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