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Anti-HIV Active Naphthyl Analogues of HEPT and DABO

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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary.

 5-Isopropyl-6-naphthyl uracil and 5-isopropyl-6-naphthyl-2-thiouracil were alkylated to give N-1-(ethoxymethyl and methylthiomethyl) uracil and S2-cyclohexyl-thiouracil, respectively. 5-Ethyl-6-naphthyl uracil and 5-ethyl-6-naphthyl-2-thiouracil afforded N-1-(ethoxymethyl, methoxy-methyl, methylthiomethyl, acetoxyethoxy methyl and hydroxyethoxy methyl) uracil and S2-((2,2- diethoxyethyl), methoxycarbonylmethyl, ethoxycarbonylpropyl, methylthiomethyl, ethoxymethyl, methyl and cyclohexyl)-thiouracil upon alkylation.

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Authors and Affiliations

  1.  Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark, , , , , , DK

    Dalia R. Imam & Erik B. Pedersen

  2.  Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt, , , , , , EG

    Ahmed A. El-Barbary

  3.  Retrovirus Laboratory, Department of Virology, State Serum Institute, DK-2300 Copenhagen, Denmark, , , , , , DK

    Claus Nielsen

Authors
  1. Dalia R. Imam
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  2. Ahmed A. El-Barbary
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  3. Claus Nielsen
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  4. Erik B. Pedersen
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Additional information

Received September 25, 2001. Accepted (revised) December 3, 2001

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Imam, D., El-Barbary, A., Nielsen, C. et al. Anti-HIV Active Naphthyl Analogues of HEPT and DABO . Monatshefte fuer Chemie 133, 723–734 (2002). https://doi.org/10.1007/s007060200044

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  • DOI: https://doi.org/10.1007/s007060200044

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