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Anisotropic Iron-Oxide Nanoparticles for Diagnostic MRI: Synthesis and Contrast Properties

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

The scientific and technical literature addressing the synthesis of anisotropic iron-oxide nanoparticles of various shapes (cubic, rod-like, clustered, etc.) sized from 10 to 100 nm and their application for diagnostic magnetic resonance imaging (MRI) of tissues and organs is analyzed. The analysis indicates that the nanoparticle shape, size, and surface chemistry affect considerably relaxation parameters T1 and T2. Thus, cubic iron-oxide nanoparticles had the greatest T2 values. Furthermore, rod-like and octapodal nanoparticles also exhibit rather high T2 values so that they can be used as contrast agents for diagnostic MRI.

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Acknowledgments

The work was financially supported by the Ministry of Education and Science of the Russian Federation [14.578.21.0201, RFMEFI57816X0201].

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Authors and Affiliations

  1. National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys), 4 Leninskii Prosp., Moscow, 119991, Russia

    A. A. Nikitin, M. A. Khramtsov, A. G. Savchenko & M. A. Abakumov

  2. Department of Chemistry, M. V. Lomonosov Moscow State University, 1/3 Leninskie Gory, GSP-1, Moscow, 119991, Russia

    A. A. Nikitin & A. G. Mazhuga

  3. N. I. Pirogov Russian National Research Medical University, 1 Ostrovityanova, Moscow, 119997, Russia

    M. A. Abakumov

  4. D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow, 125047, Russia

    A. G. Mazhuga

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  1. A. A. Nikitin
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  2. M. A. Khramtsov
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  3. A. G. Savchenko
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  4. M. A. Abakumov
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  5. A. G. Mazhuga
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Correspondence to A. A. Nikitin.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 4, pp. 36 – 40, April, 2018.

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Nikitin, A.A., Khramtsov, M.A., Savchenko, A.G. et al. Anisotropic Iron-Oxide Nanoparticles for Diagnostic MRI: Synthesis and Contrast Properties. Pharm Chem J 52, 231–235 (2018). https://doi.org/10.1007/s11094-018-1796-3

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  • DOI: https://doi.org/10.1007/s11094-018-1796-3

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