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Molecular and supramolecular interactions in systems based on microcrystalline cellulose and trichlorophene

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Abstract

It is shown that the interaction between components of the microcrystalline cellulose — trichlorophene (MCC — TCP) system can proceed via the formation of intermolecular (hydrogen) bonds and even covalent bonds, depending on the intensity of treatment and the method of mixing. These interactions have predominantly a topochemical character. For this reason, various hypotheses concerning the possible formation of new chemical substances possessing certain molecular and chemical structure and definite physicochemical properties are not valid. This conclusion is confirmed by the data of IR spectroscopy, x-ray diffraction, and electron microscopy. Therefore, such MCC — TCP reaction products may possess no specific biological activity different from that of the system components. Only the formation of a relatively small number of bonds between MCC and TCP preserves the chemical activity of TCP at a significantly increased drug release time.

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Authors and Affiliations

  1. Institute of Polymer Chemistry and Physics, Academy of Sciences of Uzbekistan Republic, Tashkent, Uzbekistan

    S. A. Fazilova, N. D. Burkhanova, S. M. Yugai, Kh. P. Pulatova, G. V. Nikonovich & S. Sh. Rashidova

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  1. S. A. Fazilova
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  2. N. D. Burkhanova
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  3. S. M. Yugai
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  4. Kh. P. Pulatova
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  5. G. V. Nikonovich
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  6. S. Sh. Rashidova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 40–43, December, 2005.

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Fazilova, S.A., Burkhanova, N.D., Yugai, S.M. et al. Molecular and supramolecular interactions in systems based on microcrystalline cellulose and trichlorophene. Pharm Chem J 39, 658–662 (2005). https://doi.org/10.1007/s11094-006-0041-7

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  • DOI: https://doi.org/10.1007/s11094-006-0041-7

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