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Surface Performance and Cytocompatibility Evaluation of Acrylic Acid-Mediated Carboxymethyl Chitosan Coating on Poly(tetrafluoroethylene-co-hexafluoropropylene)

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Abstract

To improve the biocompatibility of poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) film, a technique based on Ar plasma pretreatment and UV-induced grafting polymerization was used to immobilize carboxymethyl chitosan (CMCS) on the FEP film surfaces. Initially Ar plasma was used to treat FEP film. Then, plasma treated FEP film was modified via UV-induced grafting polymerization with hydrophilic acrylic acid (AAc) monomer. The following immobilization of CMCS on the FEP-pAAc surface was carried out via an amidation reaction. The change of chemical composition and surface morphology of FEP film were characterized by attenuated total reflectance Fourier transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electronic microscopy (SEM) and atomic force microscopy (AFM). Results of water contact angles measurement showed that the hydrophilicity of the surface has improved significantly after surface modification. Furthermore, methyl thiazolyl tetrazolium (MTT) assay and cell morphology analysis confirmed that mouse fibroblasts (L929 cells) attachment and proliferation were improved remarkably on the modified FEP surface. These results suggest that CMCS were successfully employed to surface engineering FEP film, and enhanced its cell biocompatibility. The approach presented here may be exploited for surface modification of biomaterials.

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Acknowledgments

This work is supported by the National Natural Science Foundation of China (Nos. 21273142, 51303218), the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1070), the Science and Technology Research Project of Chongqing Municipal Government (No. CSTC2012gg-yyjs10023), the Science and Technology Research Project of Xi’an City (No. CX1262②) and the innovation Funds of Graduate Programs, Shaanxi Normal University (No. 2013CXS052). We would like to thank Mr. Chen from Xi’an University of Technology for the help of AFM analysis and also Mr. Li from Xi’an Modern Chemistry Research Institute for XPS analysis.

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Authors and Affiliations

  1. Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, 710062, China

    Yashao Chen, Jinhong Yi, Qiang Gao, Xiaoling Zhou & Yanling Luo

  2. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China

    Peng Liu

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  1. Yashao Chen
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  2. Jinhong Yi
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  3. Qiang Gao
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  4. Xiaoling Zhou
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  5. Yanling Luo
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  6. Peng Liu
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Correspondence to Yashao Chen.

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Chen, Y., Yi, J., Gao, Q. et al. Surface Performance and Cytocompatibility Evaluation of Acrylic Acid-Mediated Carboxymethyl Chitosan Coating on Poly(tetrafluoroethylene-co-hexafluoropropylene). Plasma Chem Plasma Process 33, 1153–1165 (2013). https://doi.org/10.1007/s11090-013-9489-x

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  • DOI: https://doi.org/10.1007/s11090-013-9489-x

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