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The Emerging Role of Astrocytic Autophagy in Central Nervous System Disorders

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Abstract

Astrocytes act as “housekeeping cells” for maintaining cerebral homeostasis and play an important role in many disorders. Recent studies further highlight the contribution of autophagy to astrocytic functions, including astrogenesis, the astrocytic removal of neurotoxins or stressors, and astrocytic polarization. More importantly, genetic and pharmacological approaches have provided evidence that outlines the contributions of astrocytic autophagy to several brain disorders, including neurodegeneration, cerebral ischemia, and depression. In this study, we summarize the emerging role of autophagy in regulating astrocytic functions and discuss the contributions of astrocytic autophagy to different CNS disorders.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (82003727, 81872844), the Zhejiang Provincial Natural Science Foundation (LQ21H310002), and the Opening Project of the Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Zhejiang Chinese Medical University (No. 2021E10014).

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  1. Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

    Zhuchen Zhou, Jing Zhou, Zhong Chen & Yanrong Zheng

  2. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

    Jie Liao

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Zhou, Z., Zhou, J., Liao, J. et al. The Emerging Role of Astrocytic Autophagy in Central Nervous System Disorders. Neurochem Res 47, 3697–3708 (2022). https://doi.org/10.1007/s11064-022-03714-w

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