Abstract
A crucially novel type of modulation of the opioid reception is described and discussed in this review. Such a ligand as comenic acid does not bind with all sites of the receptors; it binds only to two points of the selectivity sites. Due to this, an intracellular response is not initiated (and homeostasis in the target cell is not disturbed). At the same time, the receptor is internalized (it is submerged in the membrane, and this event allows the receptor to be recovered). Thus, comenic acid functions as an allosteric modulator of opioid receptors with a rather specific mode of action. Such modulation is capable of removing cruel manifestations of the abstinence syndrome in morphine-dependent experimental animals (rats).
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Panova, T.I., Kazakov, V.M. & Shevchenko, T.O. Mechanism of the Action of Comenic Acid on Opioid Receptors. Neurophysiology 44, 322–331 (2012). https://doi.org/10.1007/s11062-012-9303-z
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DOI: https://doi.org/10.1007/s11062-012-9303-z