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Mitochondrial DNA sequence variation and risk of meningioma

  • Clinical Study
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Abstract

Background

Risk factors for meningioma include female gender, African American race, high body mass index (BMI), and exposure to ionizing radiation. Although genome-wide association studies (GWAS) have identified two nuclear genome risk loci for meningioma (rs12770228 and rs2686876), the relation between mitochondrial DNA (mtDNA) sequence variants and meningioma is unknown.

Methods

We examined the association of 42 common germline mtDNA variants (minor allele frequency ≥ 5%), haplogroups, and genes with meningioma in 1080 controls and 478 meningioma cases from a case–control study conducted at medical centers in the southeastern United States. Associations were examined separately for meningioma overall and by WHO grade (n = 409 grade I and n = 69 grade II/III).

Results

Overall, meningioma was significantly associated with being female (OR 2.85; 95% CI 2.21–3.69), self-reported African American race (OR 2.38, 95% CI 1.41–3.99), and being overweight (OR 1.48; 95% CI 1.11–1.97) or obese (OR 1.70; 95% CI 1.25–2.31). The variant m.16362T > C (rs62581341) in the mitochondrial control region was positively associated with grade II/III meningiomas (OR 2.33; 95% CI 1.14–4.77), but not grade I tumors (OR 0.99; 95% CI 0.64–1.53). Haplogroup L, a marker for African ancestry, was associated with meningioma overall (OR 2.92; 95% CI 1.01–8.44). However, after stratifying by self-reported race, this association was only apparent among the few self-reported Caucasians with this haplogroup (OR 6.35; 95% CI 1.56–25.9). No other mtDNA variant, haplogroup, or gene was associated with meningioma.

Conclusion

Common mtDNA variants and major mtDNA haplogroups do not appear to have associations with the odds of developing meningioma.

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Data availability

Data will be made available upon request.

Code availability

NA.

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Funding

This project is supported by the National Institutes of Health and the University of Alabama at Birmingham O’Neal Comprehensive Cancer Center Neuro-oncology Research Acceleration Fund (Grant no. R01CA116174); Sylvester Comprehensive Cancer Center (Grant no. CA240139); H. Lee Moffitt Cancer Center & Research Institute (Grant no. CA076292).

Author information

Authors and Affiliations

  1. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Claudine M. Samanic & Kathleen M. Egan

  2. Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL, USA

    Jamie K. Teer, Zachary J. Thompson & Brooke L. Fridley

  3. Department of Health Informatics, H. Lee Moffitt Cancer Center, Tampa, FL, USA

    Jordan H. Creed

  4. Department of Neuro-Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA

    Sepideh Mokhtari

  5. Division of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower Suite 1020 Birmingham, Birmingham, AL, USA

    L. Burt Nabors

  6. UM-CFAR/Sylvester CCC Argentina Consortium for Research and Training in Virally Induced AIDS-Malignancies University of Miami Miller School of Medicine, Miami, FL, USA

    Sion L. Williams

  7. Neurology Basic Science Division, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA

    Sion L. Williams

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  1. Claudine M. Samanic
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Contributions

All authors contributed to the study conception and design. CMS, JKT, ZJT, JHC, SM, BLF, LBN, SLW, and KME: contributed to conception and design, acquisition of data, interpretation of data. CMS: designed experiments, performed data analysis, and wrote the manuscript. JKT and ZJT: designed experiment and performed data analysis. CMS, JKT, ZJT, JHC, SM, BLF, LBN, SLW, and KME: revised manuscript for critically important intellectual content. All authors approved the final version to be published.

Corresponding author

Correspondence to Kathleen M. Egan.

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The authors declare no potential conflicts of interest.

Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. The University of South Florida Institutional Review Board approved the study.

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Informed consent was obtained from all individual participants included in the study.

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Samanic, C.M., Teer, J.K., Thompson, Z.J. et al. Mitochondrial DNA sequence variation and risk of meningioma. J Neurooncol 155, 319–324 (2021). https://doi.org/10.1007/s11060-021-03878-5

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  • DOI: https://doi.org/10.1007/s11060-021-03878-5

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