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Hypoxic Conditioning as a Stimulus for the Formation of Hypoxic Tolerance in the Brain

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This review addresses the problem of moderate hypoxic exposure as a natural, non-drug stimulus which activates the mechanisms forming hypoxic tolerance in the brain. The history and current level of research into this phenomenon are highlighted, and the conditions in which hypoxic conditioning has neuroprotective efficacy as preventive (preconditioning) and corrective (postconditioning) effects are considered. Physiological and molecular-cellular mechanisms of pre- and post-conditioning are discussed. Particular attention is paid to our own research on cerebral conditioning using mild hypobaric hypoxia.

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  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    D. G. Semenov & A. V. Belyakov

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Translated from Uspekhi Fiziologicheskikh Nauk, Vol. 54, No. 2, pp. 3–19, April–June, 2023

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Semenov, D.G., Belyakov, A.V. Hypoxic Conditioning as a Stimulus for the Formation of Hypoxic Tolerance in the Brain. Neurosci Behav Physi 53, 1242–1254 (2023). https://doi.org/10.1007/s11055-023-01520-7

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