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Effects of Single-Session Normobaric Hypoxia in Rats Aged 10 Days on Sensorimotor Development and Behavior

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Fetal or neonatal hypoxia is one of the main causes of neonatal mortality and results in long-term impairments to motor and cognitive functions. The aim of the present work was to study the effects of single-session normobaric hypoxia in rats aged 10 days (a model of premature birth in humans). Male and female Wistar rats were subjected to hypoxia for 2 h at an oxygen concentration of 8%. Control animals were kept in the same conditions but with a normal oxygen content. Levels of physical and motor development, movement and exploratory activity, and anxiety were assessed from day 11 to day 35 of life. Mortality due to exposure was 21.1%. Rats of both sexes showed slowing of weight gain and impaired production of motor reflexes. Impairments to movement coordination and balance ability were found in male but not female rats subjected to neonatal hypoxia. Female rats of adolescent age exposed to hypoxia showed increases in anxiety in the elevated plus maze test. The results provided evidence of sex dependence in the effects of neonatal hypoxia. The method used here can be regarded as a model of hypoxic brain damage in premature neonates.

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Authors and Affiliations

  1. Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia

    D. D. Khukhareva, Yu. A. Sukhanova & N. G. Levitskaya

  2. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

    E. A. Sebentsova & N. G. Levitskaya

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  1. D. D. Khukhareva
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  2. Yu. A. Sukhanova
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  3. E. A. Sebentsova
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  4. N. G. Levitskaya
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Correspondence to N. G. Levitskaya.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 107, No. 2, pp. 187–202, February, 2021.

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Khukhareva, D.D., Sukhanova, Y.A., Sebentsova, E.A. et al. Effects of Single-Session Normobaric Hypoxia in Rats Aged 10 Days on Sensorimotor Development and Behavior. Neurosci Behav Physi 51, 1153–1161 (2021). https://doi.org/10.1007/s11055-021-01175-2

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  • DOI: https://doi.org/10.1007/s11055-021-01175-2

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