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Vimentin and Glial Fibrillary Acidic Protein in the Cells of Ectopic Neural Transplants of Rat Neocortex

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The aim of the present work was to study the expression of intermediate filament proteins – vimentin and glial fibrillary acidic protein (GFAP) – in neocortical cells in rat embryos at different time points after allotransplantation into the lesioned peripheral sciatic nerve of adult animals. Immunohistochemical studies followed the formation of GFAP-positive astrocytes from vimentin-positive radial gliocytes in the neocortex rudiments of rat embryos developing in the damaged nerve. In these conditions, the formation of astrocytes by the embryo neocortex was found to occur several days earlier than in the rat neocortex in normal ontogeny. Transplants surviving for prolonged periods showed the development of reactive gliosis, as evidenced by the presence of large numbers of intensely staining GFAP-positive cells and vimentincontaining astrocytes. These data provide evidence that ectopic neural transplantation provides a model for basic studies of the mechanisms of development of reactive gliosis.

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Authors and Affiliations

  1. Laboratory for the Functional Morphology of the Central and Peripheral Nervous System (Director: Doctor of Medical Sciences D. E. Korzhevskii), Department of General and Special Morphology, Research Institute of Experimental Medicine, North-West Branch, Russian Academy of Medical Sciences, St. Petersburg, Russia

    E. S. Petrova

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Correspondence to E. S. Petrova.

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Translated from Morfologiya, Vol. 139, No. 2, pp. 22–26, March–April, 2011.

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Petrova, E.S. Vimentin and Glial Fibrillary Acidic Protein in the Cells of Ectopic Neural Transplants of Rat Neocortex. Neurosci Behav Physi 42, 598–602 (2012). https://doi.org/10.1007/s11055-012-9607-x

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