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Nanoparticle application in diabetes drug delivery

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Abstract

The management of diabetes, in contrast to the treatment of the disease, is basically aimed at controlling the blood glucose level. Besides the primary changes required in the lifestyle and diet of the patient, drug therapy can play a critical role in the diabetes management. Diabetic drugs are formulated in various forms to permit oral, transdermal, internasal, or delivery by subcutaneous injection. Notably, in formulations intended for controlled release, targeted delivery, and those requiring protection of the therapeutic agent, nanoparticles (NPs) play a crucial role. Nanoparticle-based drug formulations can also alleviate the common side effects associated with the regular administration of pure drugs. In this review, we will consider the impact of NPs on the delivery of both oral and injectable drugs to manage diabetes as well as the potential application of nanotechnology to the development of devices such as microneedles aimed at improving the delivery of diabetes drugs.

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Authors and Affiliations

  1. Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

    Seyedeh Sabereh Samavati, Soheila Kashanian & Morteza Rabiei

  2. Faculty of Chemistry, Sensor and Biosensor Research Center (SBRC) & Nanoscience and Nanotechnology Research Center (NNRC), Razi University, Kermanshah, Iran

    Soheila Kashanian

  3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Hossein Derakhshankhah

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  1. Seyedeh Sabereh Samavati
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Samavati, S.S., Kashanian, S., Derakhshankhah, H. et al. Nanoparticle application in diabetes drug delivery. J Nanopart Res 24, 178 (2022). https://doi.org/10.1007/s11051-022-05547-8

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