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Simultaneous size control and surface functionalization of titania nanoparticles through bioadhesion-assisted bio-inspired mineralization

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Abstract

Simultaneous size control and surface functionalization of inorganic nanoparticles (NPs) are often desired for their efficient applications in (bio)catalysis, drug and/or DNA delivery, and photonics, etc. In this study, a novel strategy “bioadhesion-assisted bio-inspired mineralization (BABM)” was put forward to prepare titania nanoparticles (TiNPs) with tunable particle size and multiple surface functionality. Specifically, the initial formation and subsequent growth of TiNPs were enabled by arginine via bio-inspired mineralization, while the mineralization process was terminated through the addition of the pre-polymerized dopa (oligodopa). By adjusting the addition time of oligodopa, the size of TiNPs could be facilely tailored from ca. 30–350 nm; meanwhile, the surface of TiNPs could be functionalized by oligodopa through metal–catechol coordination interaction (a typical bioadhesion phenomenon). In other words, oligodopa coating could not only exquisitely control the size of TiNPs, but also render TiNPs surface multifunctional groups for secondary treatment such as conjugating proteins through amine-catechol adduct formation. Hopefully, this BABM approach will construct a versatile platform for green and facile synthesis of inorganic NPs, in particular transition metal oxide NPs.

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Acknowledgments

The authors thank the financial support from the National Basic Research Program of China (2009CB724705), National Science Fund for Distinguished Young Scholars (21125627), the National Science Foundation of China (20976127), National Science Fund for Distinguished Young Scholars (No. 21125627), the Program of Introducing Talents of Discipline to Universities (B06006).

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Authors and Affiliations

  1. Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People’s Republic of China

    Jiafu Shi, Dong Yang, Zhongyi Jiang, Yanpeng Liang, Yuanyuan Zhu, Xiaoli Wang & Huihui Wang

  2. Department of Bioengineering, School of Chemical Engineering, Hebei University of Technology, Tianjin, 300130, People’s Republic of China

    Yanjun Jiang

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  1. Jiafu Shi
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  2. Dong Yang
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  3. Zhongyi Jiang
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  4. Yanjun Jiang
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Correspondence to Zhongyi Jiang.

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Shi, J., Yang, D., Jiang, Z. et al. Simultaneous size control and surface functionalization of titania nanoparticles through bioadhesion-assisted bio-inspired mineralization. J Nanopart Res 14, 1120 (2012). https://doi.org/10.1007/s11051-012-1120-1

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