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Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction

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Abstract

Ventricular arrhythmias are the leading cause of sudden cardiac death in patients after myocardial infarction (MI). Connexin43 (Cx43) is the most important gap junction channel-forming protein in cardiomyocytes. Dysfunction of Cx43 contributes to impaired myocardial conduction and the development of ventricular arrhythmias. Following an MI, Cx43 undergoes structural remodeling, including expression abnormalities, and redistribution. These alterations detrimentally affect intercellular communication and electrical conduction within the myocardium, thereby increasing the susceptibility to post-infarction ventricular arrhythmias. Emerging evidence suggests that post-translational modifications play essential roles in Cx43 regulation after MI. Therefore, Cx43-targeted management has the potential to be a promising protective strategy for the prevention and treatment of post infarction ventricular arrhythmias. In this article, we primarily reviewed the regulatory mechanisms of Cx43 mediated post-translational modifications on post-infarction ventricular arrhythmias. Furthermore, Cx43-targeted therapy have also been discussed, providing insights into an innovative treatment strategy for ventricular arrhythmias after MI.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 82370342) and Natural Science Foundation of Jiangsu Province (No. BK20231145).

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  1. Department of Cardiology, Wuxi People’s Hospital, Wuxi Medical Center, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Nanjing Medical University, Wuxi, 214023, China

    Fan Yang, Xiao-Lu Zhang, Ling-Ling Qian & Ru-Xing Wang

  2. Wuxi School of Medicine, Jiangnan University, Wuxi, China

    Huan-Huan Liu & Ru-Xing Wang

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F.Y. and X.Z. wrote the main manuscript text and H.L. prepared Figs. 1, 2 and 3. L.Q. and R.W. revised the manuscript. All authors reviewed the manuscript.

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Yang, F., Zhang, XL., Liu, HH. et al. Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction. Mol Biol Rep 51, 329 (2024). https://doi.org/10.1007/s11033-024-09290-2

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