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Green preparation of new pyrimidine triazole derivatives via one-pot multicomponent reactions of guanidine

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Abstract

In this research the goal was to produce novel pyrimidine triazole compounds in high yields using triethylamin as an efficient catalyst. These new compounds were synthesized by using multicomponent reaction of aldehydes, guanidine, electron deficient acetylenic compounds, tert-butyl isocyanide and hydrazonoyle chloride in aqueous media. Due to the presence of an NH group, which was assessed using two different methodologies, newly synthesized pyrimidine triazoles have antioxidant properties. Additionally, the antibacterial activity of newly created pyrimidine triazoles was assessed using the disk distribution method with two different types of Gram-positive bacteria and Gram-negative bacteria, demonstrating that the use of these compounds prevented the growth of bacteria. Applied to the preparation of pyrimidine triazole derivatives, this method has short reaction times, high product yields, and the ability to separate catalyst and product using simple procedures.

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Acknowledgements

The author sincerely would like to acknowledge the Islamic Azad University for its support.

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Authors and Affiliations

  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Nasrin Karami Hezarcheshmeh & Farideh Godarzbod

  2. Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, Erbil, Iraq

    Media Noori Abdullah

  3. Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

    Zinatossadat Hossaini

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  1. Nasrin Karami Hezarcheshmeh
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  2. Farideh Godarzbod
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  3. Media Noori Abdullah
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  4. Zinatossadat Hossaini
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Contributions

NKH, FG and MNA synthesized compounds and prepare analyse of them. ZH wrote the main manuscript text and prepare supplementary file and sending article. All of authors reviewed the manuscript.

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Correspondence to Zinatossadat Hossaini.

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Hezarcheshmeh, N.K., Godarzbod, F., Abdullah, M.N. et al. Green preparation of new pyrimidine triazole derivatives via one-pot multicomponent reactions of guanidine. Mol Divers 28, 217–228 (2024). https://doi.org/10.1007/s11030-023-10754-z

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  • DOI: https://doi.org/10.1007/s11030-023-10754-z

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