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A green, catalyst-free synthesis of pyrazolopyranopyrimidines in polyethylene glycol as a biodegradable medium at ambient temperature

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Abstract

A facile, efficient and environmentally safe strategy for the synthesis of pyrazolopyranopyrimidines via one-pot, four-component reaction of hydrazine hydrate, barbituric acid, ethyl acetoacetate, and aromatic aldehydes in polyethylene glycol (PEG) as a safe solvent in the absence of catalyst at ambient temperature has been described. The advantages of the present protocol, such as simplicity, mild conditions, high yields of products, straightforward workup procedure, a green and biodegradable reaction medium, make this new process an attractive to current methodologies.

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Authors and Affiliations

  1. Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran

    Rezvan Kardooni

  2. Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

    Rezvan Kardooni

  3. Chemistry Department, College of Science, Shahid Chamran University of Ahvaz, Ahvaz, 61357-4-3169, Iran

    Ali Reza Kiasat

Authors
  1. Rezvan Kardooni
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Correspondence to Rezvan Kardooni.

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Kardooni, R., Kiasat, A.R. A green, catalyst-free synthesis of pyrazolopyranopyrimidines in polyethylene glycol as a biodegradable medium at ambient temperature. Mol Divers 23, 639–649 (2019). https://doi.org/10.1007/s11030-018-9898-0

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  • DOI: https://doi.org/10.1007/s11030-018-9898-0

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