Abstract
An ethylene glycol promoted catalyst-free practically efficient and sustainable approach has been developed for the synthesis of several benzylidene-bis-(4-hydroxycoumarin)s and 4,\(4^{\prime }\)-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s by the pseudo three-component reaction of an aldehyde with 4-hydroxycoumarin and 3-methyl-1-phenylpyrazol-5-one, respectively. Inexpensive, non-toxic, and easily available ethylene glycol used as the reaction solvent and promoter renders an efficient protocol in terms of catalyst-free reaction conditions, short reaction time, high yield, practical utility, and green approach.
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Authors are thankful to the Director, SAIF, Chandigarh for providing spectral data.
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Kauthale, S.S., Tekale, S.U., Jadhav, K.M. et al. Ethylene glycol promoted catalyst-free pseudo three-component green synthesis of bis(coumarin)s and bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s. Mol Divers 20, 763–770 (2016). https://doi.org/10.1007/s11030-016-9673-z
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DOI: https://doi.org/10.1007/s11030-016-9673-z