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Apolipoprotein-AI and AIBP synergetic anti-inflammation as vascular diseases therapy: the new perspective

Abstract

Vascular diseases (VDs) including pulmonary arterial hypertension (PAH), atherosclerosis (AS) and coronary arterial diseases (CADs) contribute to the higher morbidity and mortality worldwide. Apolipoprotein A-I (Apo A-I) binding protein (AIBP) and Apo-AI negatively correlate with VDs. However, the mechanism by which AIBP and apo-AI regulate VDs still remains unexplained. Here, we provide an overview of the role of AIBP and apo-AI regulation of vascular diseases molecular mechanisms such as vascular energy homeostasis imbalance, oxidative and endoplasmic reticulum stress and inflammation in VDs. In addition, the role of AIBP and apo-AI in endothelial cells (ECs), vascular smooth muscle (VSMCs) and immune cells activation in the pathogenesis of VDs are explained. The in-depth understanding of AIBP and apo-AI function in the vascular system may lead to the discovery of VDs therapy.

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Fig. 1

Abbreviations

AS:

Atherosclerosis

Apo-AI:

Apolipoprotein-AI

AIBP:

Apo-AI binding protein

PAH:

Pulmonary arterial hypertension

EAH:

Essential arterial hypertension

CADs:

Coronary arterial diseases

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This research was supported by the Natural Science Foundation of Hunan Province, China (2018JJ2346).

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Jackson, A.O., Rahman, G.A. & Long, S. Apolipoprotein-AI and AIBP synergetic anti-inflammation as vascular diseases therapy: the new perspective. Mol Cell Biochem 476, 3065–3078 (2021). https://doi.org/10.1007/s11010-020-04037-6

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Keywords

  • AIBP: apolipoprotein-AI: ATP: oxidation stress
  • Inflammation: endothelial cell
  • Vascular smooth muscle cell
  • Immune cells: atherosclerosis
  • Pulmonary arterial hypertension
  • Coronary arterial diseases