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Thermal analysis of tetracyclines: a review

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Abstract

A revision on articles concerning thermal analysis of tetracyclines is presented, regarding drug-excipient compatibility, characterization of drug releasing systems, physicochemical behavior of drug-supported systems and degradation of some pharmaceuticals itself. Initially, an overview of information regarding this class of drugs is presented. A bibliographic survey revealed relatively few works on this subject despite the worldwide use and relevance of this class of antibiotics. Here, 37 papers published during the time frame 2000–2022 were classified as above and discussed once they presented thermoanalytical data straightly related to the tetracyclines. From the thermal studies of the drugs, a general decomposition behavior could be identified and it is presented.

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Abbreviations

TCs:

General abbreviation for tetracyclines

TC:

Tetracycline

TCH:

Tetracycline hydrochloride

OTC:

Oxytetracycline

DOX:

Doxycycline

DOX-SLN:

Doxycycline-loaded solid lips nanoparticles

OTCH:

Oxytetracycline hydrochloride

CTCH:

Chlortetracycline hydrochloride

MNC:

Minocycline

AHTC:

Anhydrotetracycline

Meclo:

Meclocycline

TGA:

Thermogravimetry

DTG:

Derivative thermogravimetry

DTA:

Differential thermal analysis

DSC:

Differential scanning calorimetry

EGA:

Evolved gas analysis

TGA-FTIR:

Thermogravimetry coupled to Fourier transform infrared spectroscopy

AFM:

Atomic force microscopy

DLS:

Dynamic light scattering

FTIR:

Fourier transform infrared spectroscopy

31P-NMR :

Phosphorus-31 nuclear magnetic resonance

1H-NMR :

Hydrogen nuclear magnetic resonance

XRPD:

X-ray powder diffraction

VLI:

Visible light irradiation

Rp:

Propagation rate constant

IP:

Induction period

AIBN:

Azobisisobutyronitrile

BPO:

Benzoyl peroxide

BSA:

Bovine serum albumin

CTAB:

Cetrimonium bromide

HCECs:

Human corneal eukaryotic cells

HPMC:

Hydroxypropyl methylcellulose

k-carrageenan:

Kappa carrageenan

MMA:

Methyl methacrylate

MMW:

Miracle mouthwash

Mt:

Montmorillonite

Pal:

Palygorskite

PCL:

poly(ε-Caprolactone)

PLA-HAP-DOX:

Polylactic acid-hydroxyapatite-doxycycline

PLGA:

poly(D,L-Lactide-co-glycolide)

PLLA:

poly(L-lactic acid)

PLLA-PEG-PLLA:

poly(L,L-Lactide)-b-poly(ethylene glycol)-b-poly(L,L-lactide)

PMMA:

poly(Methyl methacrylate)

PVA-SbQ:

poly(Vinyl alcohol)-stilbazole quaternized

RAL:

Raloxifene HCl

Sep:

Sepiolite

SLST:

Surfactants sodium lauryl sulfate

Veegum© :

Montmorillonite

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Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo,2019/22217-8,Eder Cavalheiro,Coordenação de Aperfeiçoamento de Pessoal de Nível Superior,Conselho Nacional de Desenvolvimento Científico e Tecnológico

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  1. Instituto de Química de São Carlos, Universidade de São Paulo, Av. Trabalhador São-Carlense, 400, São Carlos, SP, 13566-590, Brazil

    Jonatha de Freitas, Ana Paula Garcia Ferreira & Éder Tadeu Gomes Cavalheiro

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  1. Jonatha de Freitas
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  3. Éder Tadeu Gomes Cavalheiro
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JdF involved in bibliographic revision, article selection, writing and revision and editing; APGF involved in bibliographic revision, article selection, writing and revision and editing; ÉTGC involved in conceptualization, article selection, revision and editing, project administration and funding acquisition.

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de Freitas, J., Ferreira, A.P.G. & Cavalheiro, É.T.G. Thermal analysis of tetracyclines: a review. J Therm Anal Calorim (2023). https://doi.org/10.1007/s10973-023-12308-9

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