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Study of thermally induced interaction between hydroxyethylcellulose and carboxymethylcellulose with different excipients

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Abstract

The aim of the present paper was the study of excipient–excipient interactions. It presents the compatibility study between two polymeric compounds used in pharmaceutical technology, namely carboxymethylcellulose and hydroxyethylcellulose, with other commonly used pharmaceutical excipients, such as polyvinylpyrrolidone, sorbitol, magnesium stearate, and talc. The compatibility investigations were carried out under ambient temperature and after decomposition by FTIR spectroscopy studies and later completed by the use of thermal analysis (TG/DTG/HF) data to study the influence of temperature over stability of binary mixtures. Carboxymethylcellulose and hydroxyethylcellulose present thermal-induced interactions with sorbitol and magnesium stearate.

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Authors and Affiliations

  1. Research Center: Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, RO, Romania

    Gabriela Vlase, Roxana Blajovan, Paul Albu & Titus Vlase

  2. Department of Pharmaceutical Sciences, Faculty of Pharmacy, „Vasile Goldis” Western University of Arad, 86 L. Rebreanu St., 310414, Arad, RO, Romania

    Paul Albu

Authors
  1. Gabriela Vlase
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  2. Roxana Blajovan
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  3. Paul Albu
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  4. Titus Vlase
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Correspondence to Titus Vlase.

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Vlase, G., Blajovan, R., Albu, P. et al. Study of thermally induced interaction between hydroxyethylcellulose and carboxymethylcellulose with different excipients. J Therm Anal Calorim 130, 397–402 (2017). https://doi.org/10.1007/s10973-017-6309-1

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  • DOI: https://doi.org/10.1007/s10973-017-6309-1

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