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Study of thermal induced excipient–excipient interactions

polyvinyl alcohol and polyvinylpyrrolidone with other pharmaceutical excipients

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Abstract

This paper deals with the study of excipient–excipient interactions, rather than more commonly studied drug–excipient interactions. It presents the compatibility study between two polymeric compounds used in pharmaceutical technology, namely polyvinyl alcohol and polyvinylpyrrolidone, with other commonly used pharmaceutical excipients, like starch, mannitol, sorbitol, magnesium stearate and hydroxyethyl cellulose. The compatibility investigations were carried out under ambient temperature by FTIR spectroscopy studies and later completed by the use of thermal analysis (TG/DTG/HF) data to study the influence of temperature over stability of binary mixtures.

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Acknowledgements

Roxana Blajovan (Ph.D. student) was cofinanced in this work from the European Social Fund through Sectoral Operational Programme Human Resources Development 2007–2013, Project Number POSDRU/187/1.5/S/155559, Competitive Multidisciplinary Doctoral Research in Europe.

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Authors and Affiliations

  1. Research Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, 16 Pestalozzi Street, 300115, Timisoara, Romania

    Roxana Blajovan, Gabriela Vlase & Titus Vlase

  2. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, 2 Eftimie Murgu Square, 300041, Timisoara, Romania

    Ionuţ Ledeţi & Adriana Ledeţi

Authors
  1. Roxana Blajovan
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  2. Ionuţ Ledeţi
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  3. Gabriela Vlase
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  4. Adriana Ledeţi
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  5. Titus Vlase
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Correspondence to Adriana Ledeţi.

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Blajovan, R., Ledeţi, I., Vlase, G. et al. Study of thermal induced excipient–excipient interactions. J Therm Anal Calorim 126, 171–179 (2016). https://doi.org/10.1007/s10973-016-5348-3

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  • DOI: https://doi.org/10.1007/s10973-016-5348-3

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