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Thermal stability of ketoprofen—active substance and tablets

Part 1. Kinetic study of the active substance under non-isothermal conditions

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Abstract

Simultaneous thermoanalytical techniques were used for the characterization of the thermal decomposition of ketoprofen—active substance and tablets. DTA and DSC curves showed that ketoprofen melts before the decomposition. A kinetic study regarding the ketoprofen—active substance’s thermal decomposition was performed under non-isothermal conditions and in a nitrogen atmosphere at five heating rates: 2.5, 5, 7.5, 10 and 15 °C min−1. The kinetic parameters of thermal decomposition process were obtained from TG/DTG curves using the following differential methods: Friedman isoconversional, Chang, respectively, integral methods: Flynn–Wall–Ozawa, Kissinger–Akahira–Sunose, Coats–Redfern and Madhusudanan. The careful treatment of the kinetic parameters obtained in certain thermal conditions was confirmed to be necessary as well as a different strategy of experimental data processing.

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Authors and Affiliations

  1. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, Timisoara, 300041, Roumania

    Dumitru Tiţa, Adriana Fuliaş & Bogdan Tiţa

  2. Industrial Chemistry and Environmental Engineering Faculty, Politehnica University of Timişoara, Victoriei Square 2, Timisoara, 300006, Roumania

    Bogdan Tiţa

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  1. Dumitru Tiţa
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  2. Adriana Fuliaş
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  3. Bogdan Tiţa
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Correspondence to Dumitru Tiţa.

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Tiţa, D., Fuliaş, A. & Tiţa, B. Thermal stability of ketoprofen—active substance and tablets. J Therm Anal Calorim 105, 501–508 (2011). https://doi.org/10.1007/s10973-010-1187-9

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