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Thermal analysis of prednicarbate and characterization of thermal decomposition product

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Abstract

In the present work, the thermal behavior of prednicarbate was studied using DSC and TG/DTG. The solid product remaining at the first decomposition step of the drug was isolated by TG, in air and N2 atmospheres and was characterized using LC-MS/MS, NMR, and IR spectroscopy. It was found that the product at the first thermal decomposition step of prednicarbate corresponds to the elimination of the carbonate group bonding to C17, and a consequent formation of double bond between C17 and C16. Structure elucidation of this degradation product by spectral data has been discussed in detail.

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Acknowledgements

The authors acknowledge to Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), and Stiefel Laboratories for the financial support.

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Authors and Affiliations

  1. Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil

    Hélio Salvio Neto

  2. Stiefel Laboratories, 1081/1301 Prof. João Cavalheiro Salem Street, Guarulhos, São Paulo, Brazil

    Hélio Salvio Neto

  3. Core Clinical Research, 171 Tancredo de Almeida Neve Avenue, Bragança Paulista, SP, Brazil

    Fábio Alessandro Proença Barros

  4. Departamento de Mineralogia e Geotectônia, Instituto de Geociências, Universidade de São Paulo, São Paulo, SP, Brazil

    Flávio Machado de Sousa Carvalho

  5. Departamento de Química Fundamental Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil

    Jivaldo Rosário Matos

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  1. Hélio Salvio Neto
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  2. Fábio Alessandro Proença Barros
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  3. Flávio Machado de Sousa Carvalho
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Correspondence to Jivaldo Rosário Matos.

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Salvio Neto, H., Barros, F.A.P., de Sousa Carvalho, F.M. et al. Thermal analysis of prednicarbate and characterization of thermal decomposition product. J Therm Anal Calorim 102, 277–283 (2010). https://doi.org/10.1007/s10973-009-0419-3

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  • DOI: https://doi.org/10.1007/s10973-009-0419-3

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